The effect of non-invasive dermal electroporation on skin barrier function and skin permeation in combination with different dermal formulations

Kis, Nikolett; Kovács, Anita; Budai-Szűcs, Mária; Erős, Gábor; Csányi, Erzsébet; Berkó, Szilvia

doi:10.1016/j.jddst.2022.103161

Cited by 7 publications

(5 citation statements)

References 46 publications

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“…ImageJ1 software was employed to assess the color intensity of the images, representing the distribution of color intensity within each image. The increase in intensity is indicated as relative intensity (RI), signifying how many times the increase in intensity compares to the negative control (untreated skin) [ 27 ].…”

Section: Methodsmentioning

confidence: 99%

Foams Set a New Pace for the Release of Diclofenac Sodium

Falusi,

Berkó,

Budai-Szűcs

et al. 2024

Pharmaceutics

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Medicated foams have emerged as promising alternatives to traditional carrier systems in pharmaceutical research. Their rapid and convenient application allows for effective treatment of extensive or hirsute areas, as well as sensitive or inflamed skin surfaces. Foams possess excellent spreading capabilities on the skin, ensuring immediate drug absorption without the need for intense rubbing. Our research focuses on the comparison of physicochemical and biopharmaceutical properties of three drug delivery systems: foam, the foam bulk liquid, and a conventional hydrogel. During the development of the composition, widely used diclofenac sodium was employed. The safety of the formulae was confirmed through an in vitro cytotoxicity assay. Subsequently, the closed Franz diffusion cell was used to determine drug release and permeation in vitro. Ex vivo Raman spectroscopy was employed to investigate the presence of diclofenac sodium in various skin layers. The obtained results of the foam were compared to the bulk liquid and to a conventional hydrogel. In terms of drug release, the foam showed a rapid release, with 80% of diclofenac released within 30 min. In summary, the investigated foam holds promising potential as an alternative to traditional dermal carrier systems, offering faster drug release and permeation.

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Section: Methodsmentioning

confidence: 99%

Foams Set a New Pace for the Release of Diclofenac Sodium

Falusi,

Berkó,

Budai-Szűcs

et al. 2024

Pharmaceutics

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“…Electroporation for skin-mediated drug delivery is a method in which high-voltage pulses are applied to permeate drugs from small molecules to macromolecules (Figure 2g). [109,110] A voltage gradient across the skin layer of 30 to 100 V induces rearrangement of the lipid bilayer membrane by temporarily disturbing the structure, which results in the formation of pores and aqueous pathways that allow high-molecular drugs to permeate through. [111,112] During pulsing, pores with sizes of as small as 10 nm, and with a short lifetime between a few microseconds to a few seconds scale are formed and skin resistance decreases, which is partially reversible.…”

Section: Stimuli-enhanced Methodsmentioning

confidence: 99%

Advancements in Skin‐Mediated Drug Delivery: Mechanisms, Techniques, and Applications

Lee,

Lim,

Kwak

et al. 2023

Adv Healthcare Materials

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Skin‐mediated drug delivery methods currently are receiving significant attention as a promising approach for the enhanced delivery of drugs through the skin. Skin‐mediated drug delivery offers the potential to overcome the limitations of traditional drug delivery methods, including oral administration and intravenous injection. The challenges associated with drug permeation through layers of skin, which act as a major barrier, are explored, and strategies to overcome these limitations are discussed in detail. This review categorizes skin‐mediated drug delivery methods based on the means of increasing drug permeation, and it provides a comprehensive overview of the mechanisms and techniques associated with these methods. In addition, recent advancements in the application of skin‐mediated drug delivery are presented. The review also outlines the limitations of ongoing research and suggests future perspectives of studies regarding the skin‐mediated delivery of drugs.

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“…Therefore, technologies that allow the permeation of actives in different layers of the skin have been studied by scholars. (KIS, 2022;NORLEN, 2022;YOSHIDA, 2022).…”

Section: Skin and Dermocosmeticsmentioning

confidence: 99%

“…Thus, to achiev the expected result, the actives contained in the formulation need to reach their target and effectively accomplish the topical action without being absorbed by the body, thus avoiding an unwanted systemic effect. Therefore, the bioactive must be absorbed by the epidermis, reaching the basal stratum and eventually the dermis (KIS, 2022;NORLEN, 2022;YOSHIDA, 2022).…”

Section: Essential Oils and Vegetable Oilsmentioning

confidence: 99%

Nanoencapsulation of essential and vegetable oils to obtain polymeric nanoparticles for dermocosmetics application

Januário¹,

Iulianelli²

2023

Ciências Da Saúde E Suas Descobertas Científicas

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Essential and vegetable oils are rich in bioactives, which can act on the skin through their therapeutic properties. However, they are often sensitive to oxidation and degradation, making it necessary to use resources for their protection. The nanoencapsulation of these oils allows bioactives to have their properties protected and optimized through the sustained release of actives, reduced toxicity, and even greater penetration capacity and better distribution in the skin layers, enhancing their effects. Polymeric nanoparticles, particularly, have shown important results for delivery of bioactives to the skin, and can be produced from natural or synthetic polymers, which present biocompatibility and biodegradability. The main methods for obtaining these nanostructured materials are nanoprecipitation, coacervation and ionic gelation, and these methods are the scope of this literature review.

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The effect of non-invasive dermal electroporation on skin barrier function and skin permeation in combination with different dermal formulations

Cited by 7 publications

References 46 publications

Foams Set a New Pace for the Release of Diclofenac Sodium

Foams Set a New Pace for the Release of Diclofenac Sodium

Advancements in Skin‐Mediated Drug Delivery: Mechanisms, Techniques, and Applications

Nanoencapsulation of essential and vegetable oils to obtain polymeric nanoparticles for dermocosmetics application

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