The effect of non-steroidal anti-inflammatory drugs on matrix metalloproteinases levels in patients with osteoarthritis

Efstathiou, Maria; Settas, Loukas

doi:10.31138/mjr.28.3.133

Cited by 9 publications

(6 citation statements)

References 42 publications

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“…alpha in human chondrocytes. A conducted by Efstathiou et al (2017) on 36 OA patients who were given NSIDs reported that MMP-3 levels were significantly reduced after NSAID treatment [38]. Matrine is an anti-inflammatory, also shown to inhibit IL-1β-induced matrix metalloproteinase expression by suppressing MAPK and NF-B activation in human chondrocytes in vitro.…”

Section: Levels Of Il-1β and Tnf-α With Mmp3 Gene Expression Rs679620mentioning

confidence: 99%

Risk factor of elevated matrix metalloproteinase-3 gene expression in synovial fluid in knee osteoarthritis women

et al. 2023

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Introduction Metalloproteinases-3 (MMP3) are the main enzymes involved in cartilage degradation. Several genetic and non-genetic factors can increase the expression of MMP3 in patients with osteoarthritis (OA). This study aims to analyze the risk factors associated with the expression of the MMP3 gene rs679620 fluid synovial knee OA patients. Methods A cross-sectional study was conducted at the orthopedic polyclinic Arifin Achmad Riau Province and Ibn Sina Hospital in Pekanbaru City. Ninety women who experienced knee OA were taken as samples by consecutive sampling and then signed the informed consent. Data were obtained through interviews using a questionnaire about characteristics, followed by weight and height measurements. Interleukin-1 β (IL-1β) and Tumor Necrosis Factor (TNF-α) were examined from the synovial fluid using the enzyme-linked immunosorbent assay (ELISA) method. The Metalloproteinases-3 (MMP3) gene polymorphism rs679620 was obtained from the DNA analysis of joint fluid results in the Biomedical Laboratory of the Faculty of Medicine, Andalas University. The data was processed computerized and then analyzed using the correlation Spearman-Rank, and chi-square tests. The results of statistical analysis are considered significant if the p-value is 0.05. Results The MMP3 rs679620 gene polymorphism of the mutant type was 88.9%, with the same proportion of AG and GG alleles (44.4%). Subjects aged ≥ 60 years were 53.3%, 85.6% did not work and 84.4% had menopause. The highest degree of OA was grade 2 (53.3%), most of whom had a risky nutritional status (84.4%). The median expression of the MMP3 rs679620 gene was 5.28 copies number. There is a significant relationship between MMP3 gene polymorphism rs679620, age, IL-1β, and TNF-α with MMP3 gene expression rs679620. There is no significant relationship between BMI, work status, and menopausal status with MMP3 gene expression rs679620. Conclusion. MMP3 gene polymorphism rs679620, age, levels of IL-1β and TNF-α are risk factors for increased MMP3 gene rs679620 expression in female knee OA.

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Section: Levels Of Il-1β and Tnf-α With Mmp3 Gene Expression Rs679620mentioning

confidence: 99%

Risk factor of elevated matrix metalloproteinase-3 gene expression in synovial fluid in knee osteoarthritis women

et al. 2023

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“…However, the expression level of MMP-3 also changes along with disease progression and remission, which suggests MMP-3 may be a marker of curative effects. Serum MMP-3 levels in patients with OA were significantly decreased after treatment with non-steroidal anti-inflammatory drugs (Efstathiou and Settas, 2017) and decreased significantly in RA patients treated with certolizumab pegol (Ling et al, 2017). Other studies in which RA patients were treated with methotrexate monotherapy (Kazuko et al, 2016) and AS patients were treated with etanercept (Dongyi et al, 2017) showed similar results to those described above.…”

Section: Clinical Detection and Inhibitors Of Mmp-3 Mmp-3 Detectionmentioning

confidence: 99%

Matrix Metalloproteinase 3: A Promoting and Destabilizing Factor in the Pathogenesis of Disease and Cell Differentiation

Wan

Zhang

et al. 2021

Front. Physiol.

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Cells must alter their expression profiles and morphological characteristics but also reshape the extracellular matrix (ECM) to fulfill their functions throughout their lifespan. Matrix metalloproteinase 3 (MMP-3) is a member of the matrix metalloproteinase (MMP) family, which can degrade multiple ECM components. MMP-3 can activate multiple pro-MMPs and thus initiates the MMP-mediated degradation reactions. In this review, we summarized the function of MMP-3 and discussed its effects on biological activities. From this point of view, we emphasized the positive and negative roles of MMP-3 in the pathogenesis of disease and cell differentiation, highlighting that MMP-3 is especially closely involved in the occurrence and development of osteoarthritis. Then, we discussed some pathways that were shown to regulate MMP-3. By writing this review, we hope to provide new topics of interest for researchers and attract more researchers to investigate MMP-3.

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“…All OA group dogs received a non-steroidal anti-inflamatory drug (NSAID) in the first 7-10 days after surgical intervention which may have impacted the results of follow up serum and SF biomarker measurements in this study. A previous study that has evaluated the effect of NSAID use on collagenase and general MMP activity in cartilage, and synovium did not show a significant difference compared to controls despite 8 weeks of use in a tCrCL model [52] In vitro studies have shown a dose-dependent suppressive effect by NSAIDs on MMPs in human synovial fibroblasts and bovine chondrocyte models [53,54] as well as in clinical trials of human knee OA [55]. However, the impact of the suppressive effect of the short term meloxicam used in this study on the serum and SF biomarker measurements at T2 and T3 are unknown.…”

Section: Plos Onementioning

confidence: 99%

Evaluation of serum MMP-2 and MMP-3, synovial fluid IL-8, MCP-1, and KC concentrations as biomarkers of stifle osteoarthritis associated with naturally occurring cranial cruciate ligament rupture in dogs

et al. 2020

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The purpose of this study was to evaluate matrix metalloproteinases (MMP) -2 and MMP-3 in serum, and keratinocyte-derived chemoattractant (KC), interleukin 8 (IL-8) and monocyte chemoattractant 1 (MCP-1) in synovial fluid (SF) as stifle osteoarthritis (OA) biomarkers in dogs. Dogs with naturally occurring cranial cruciate ligament (CrCL) rupture (OA group) and healthy controls were recruited. Stifles with CrCL deficiency were surgically stabilized. Serum, SF, and synovial biopsy samples were collected from the OA group preoperatively, whereas samples were collected once from control dogs. A blinded veterinary pathologist graded synovial biopsies. Serum and SF analyses were performed using xMAP technology. General linear regression was used for statistical comparisons of serum biomarkers, and mixed linear regression for SF biomarkers and temporal concentration changes. The overall discriminative ability was quantified using area under curve (AUC). Spearman’s correlation coefficient was used to assess correlations between synovial histology grades and the biomarkers. Samples from 62 dogs in the OA group and 50 controls were included. The MMP-2 and MMP-3 concentrations between the OA and control groups were not significantly different, and both with an AUC indicating a poor discriminative ability. All three SF biomarker concentrations were significantly different between the OA group and controls (P <0.05). The MCP-1 was the only biomarker showing an acceptable discriminative performance with an AUC of 0.91 (95% confidence interval: 0.83–0.98). The sum of the inflammatory infiltrate score was significantly correlated with all three SF biomarkers (P <0.01). Summed synovial stroma, and all scores combined were significantly correlated with IL-8 and MCP-1 concentrations (P <0.003), and the summed synoviocyte scores were significantly correlated with MCP-1 concentrations (P <0.001). Correlations between MCP-1 concentrations and synovial histopathologic grading and its discriminative ability suggest its potential as a synovitis biomarker in canine stifle OA associated with CrCL rupture.

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The effect of non-steroidal anti-inflammatory drugs on matrix metalloproteinases levels in patients with osteoarthritis

Cited by 9 publications

References 42 publications

Risk factor of elevated matrix metalloproteinase-3 gene expression in synovial fluid in knee osteoarthritis women

Risk factor of elevated matrix metalloproteinase-3 gene expression in synovial fluid in knee osteoarthritis women

Matrix Metalloproteinase 3: A Promoting and Destabilizing Factor in the Pathogenesis of Disease and Cell Differentiation

Evaluation of serum MMP-2 and MMP-3, synovial fluid IL-8, MCP-1, and KC concentrations as biomarkers of stifle osteoarthritis associated with naturally occurring cranial cruciate ligament rupture in dogs

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