The effect of nonsurgical periodontal treatment on gingival crevicular fluid stress hormone levels: A prospective study

Çakmak, Ömer; Alkan, Banu Arzu; Saatçi, Ebru; Taşdemir, Zekeriya

doi:10.1111/odi.12973

Cited by 8 publications

(6 citation statements)

References 51 publications

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“…The NCT04315532 trial evaluated the impact of periodontal treatment on estrogen and dehydroepiandrosterone (DHEA) levels, whereas the NCT01422122 study assessed the role of vitamin D supplementation. It was shown that DHEA levels correlated with PD severity [ 168 ]. Non-surgical treatment did not influence DHEA levels [ 169 ].…”

Section: Clinicaltrialsgov Analysismentioning

confidence: 99%

Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring

Starzyńska

Wychowański

Nowak

et al. 2022

IJMS

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Periodontal disease (PD) is one of the most common oral conditions affecting both youths and adults. There are some research works suggesting a high incidence of PD in pregnant women. As an inflammatory disease of bacterial origin, PD may result in the activation of the pathways affecting the course and the pregnancy outcome. The authors, based on the literature review, try to answer the PICO question: Does maternal periodontitis (exposure) influence the incidence of complications rates in pregnancy and the development of systemic diseases in childhood and adult offspring (outcome) in the humans of any race (population) compared to the offspring of mothers with healthy periodontium (comparison)? The authors try to describe the molecular pathways and mechanisms of these interdependencies. There is some evidence that maternal periodontitis may affect the pregnancy course and outcome, resulting in preeclampsia, preterm delivery, vulvovaginitis and low birth weight. It can be suggested that maternal periodontitis may affect offspring epigenome and result in some health consequences in their adult life.

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Section: Clinicaltrialsgov Analysismentioning

confidence: 99%

Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring

Starzyńska

Wychowański

Nowak

et al. 2022

IJMS

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“…Odds ratio for depression among periodontitis vs controls 1.28 (95% CI 0.56–2.95). fair Case-control studies (Human): Total studies with positive associations between IPD and MD: 6; negative associations: 0; not shown or unclear: 1 Prospective cohort studies (Human) Cakmak et al. (2019) , Turkey 55:15 healthy controls; 40 subjects with periodontitis Dental outpatients, 40.4 (26–63) yrs., 40% women Patients with chronic localized and generalized periodontitis vs healthy controls Localized or generalized chronic periodontitis (based on PI, GI, BOP, PPD, CAL).…”

Section: Resultsmentioning

confidence: 99%

“…IgG against Bacteroides forsythus specifically related to periodontitis patients with depression. Prospective cohort studies (Human) Cakmak et al. (2019) Cortisol, DHEA GCF/ELISA Higher cortisol (pg/ml) levels in localized (338.2 ± 309) and generalized (388.0 ± 368) chronic periodontitis compared to patient controls (81.4 ± 27) p < 0.001.…”

Section: Resultsmentioning

confidence: 99%

“…Most studies reported cortisol levels measured in saliva, GCF, serum or urine to be positively correlated with periodontal disease ( Bawankar et al., 2018 ; Cakmak et al., 2014 , 2016 ; Cohen-Cole et al., 1983 ; Fenol et al., 2017 ; Rahate et al., 2021 ; Refulio et al., 2013 ; Rosania et al., 2009 ). However, five studies found no associations between salivary cortisol and periodontal disease ( Cakmak et al., 2019 ; da Silva et al., 2015 ; Kurer et al., 1995 ; Petit et al., 2020 ; Zhang et al., 2021 ). While Zhang et al.…”

Section: Resultsmentioning

confidence: 99%

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Biomarkers common for inflammatory periodontal disease and depression: A systematic review

Virtej

Myhren

Bull

2022

Brain, Behavior, & Immunity - Health

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“…In this study, we aimed to evaluate the impact of depression and anxiety assessed with STAI and BDI questionnaires on periodontal treatment outcomes. The French versions of STAI and BDI were selected due to their strong validation, reliability, internal consistency and extensive use in order to evaluate the association between psychological status and chronic diseases [38][39][40][41]. In a previous analysis where depression level was measured using the depression score of the DASS-42 self-administered questionnaire, an association between depression and worsened SRP outcomes was observed, especially regarding the evolution of BOP and reduction in deep sites with PPD > 5 mm and >7 mm [20].…”

Section: Discussionmentioning

confidence: 99%

Influence of Depression and Anxiety on Non-Surgical Periodontal Treatment Outcomes: A 6-Month Prospective Study

Petit

Anadon-Rosinach

Tuzin

et al. 2021

IJERPH

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Periodontal treatment could be worsened by risk factors. Depression and anxiety have been suggested as potentially influencing periodontal treatment outcomes. The aim of this study was to determine their association with non-surgical periodontal treatment outcomes in patients with generalized severe periodontitis (stage III/IV generalized periodontitis) at 6 months. A total of 68 patients diagnosed with generalized severe periodontitis were treated with scaling and root planing (SRP) and were followed at 3 and 6 months. The data of the 54 patients that followed the entire protocol were considered for analysis. Depression and anxiety levels were determined at baseline by the Beck Depression Inventory (BDI) and State-Trait Inventory (STAI) questionnaires. The association between psychological scores and periodontal parameters was evaluated by multivariate analysis. At 3 and 6 months, SRP induced an improvement for all periodontal parameters (plaque index (PI), bleeding on probing (BOP), periodontal probing depth (PPD) and clinical attachment loss (CAL)). BDI and STAI scores were associated with the evolution of PI, BOP, mean PPD and number of sites with PPD > 3 mm and with CAL > 3 mm. Depression and anxiety should be considered as risk factors for SRP and the identification of at-risk patients should be performed using well-established tools.

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The effect of nonsurgical periodontal treatment on gingival crevicular fluid stress hormone levels: A prospective study

Abstract: Within the limits of the study, decreased GCF COR and unchanged GCF DHEA levels were determined in nonsurgically treated patients regardless of the extent and severity of periodontitis.

Cited by 8 publications

References 51 publications

Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring

Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring

Biomarkers common for inflammatory periodontal disease and depression: A systematic review

Influence of Depression and Anxiety on Non-Surgical Periodontal Treatment Outcomes: A 6-Month Prospective Study

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