The effect of nozzle-exit-channel shape on resultant fiber diameter in melt-electrospinning

Esmaeilirad, Ahmad; Ko, Junghyuk; Rukosuyev, Maxym V.; Lee, Jason K.; Lee, Patrick; Jun, Martin Byung‐Guk

doi:10.1088/2053-1591/4/1/015302

Cited by 9 publications

(4 citation statements)

References 32 publications

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“…Esmaeilirad et al used different nozzle-exit-channel shapes to examine the impact on the generated fiber diameter. Among the nozzle-exit-channel investigated, the rectangular nozzles were able to generate the smallest fibers with a reduction in fiber diameter of up to 50% compared to circular opening with comparable nozzle-exit-channel cross section area ( Esmaeilirad et al, 2017 ).…”

Section: Combination Of Mew With Other Techniquesmentioning

confidence: 99%

Recent advances in melt electro writing for tissue engineering for 3D printing of microporous scaffolds for tissue engineering

Loewner

Heene

Baroth

et al. 2022

Front. Bioeng. Biotechnol.

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Melt electro writing (MEW) is a high-resolution 3D printing technique that combines elements of electro-hydrodynamic fiber attraction and melts extrusion. The ability to precisely deposit micro- to nanometer strands of biocompatible polymers in a layer-by-layer fashion makes MEW a promising scaffold fabrication method for all kinds of tissue engineering applications. This review describes possibilities to optimize multi-parametric MEW processes for precise fiber deposition over multiple layers and prevent printing defects. Printing protocols for nonlinear scaffolds structures, concrete MEW scaffold pore geometries and printable biocompatible materials for MEW are introduced. The review discusses approaches to combining MEW with other fabrication techniques with the purpose to generate advanced scaffolds structures. The outlined MEW printer modifications enable customizable collector shapes or sacrificial materials for non-planar fiber deposition and nozzle adjustments allow redesigned fiber properties for specific applications. Altogether, MEW opens a new chapter of scaffold design by 3D printing.

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Section: Combination Of Mew With Other Techniquesmentioning

confidence: 99%

Recent advances in melt electro writing for tissue engineering for 3D printing of microporous scaffolds for tissue engineering

Loewner

Heene

Baroth

et al. 2022

Front. Bioeng. Biotechnol.

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“…[10] Without question, the gold standard polymer for MEW is poly(𝜖-caprolactone (PCL) due to its ease of fabrication, availability (including medical grade standard), and low range of melting temperatures. [11] This relatively soft polymer also renders a flexible scaffold with mechanical properties close to soft biological tissues and a non-hazardous in vivo degradation rate. [12] MEW process parameters have been extensively investigated with CTS, [13] collector speed, collector distance and pressure, [14] polymer melt viscosity, [10] and nozzle-exit-channel shape [11] all individually having a significant influence on printing and the resultant fibers being collected.…”

Section: Introductionmentioning

confidence: 99%

A Deeper Insight into the Influence of the Electric Field Strength When Melt‐Electrowriting on Non‐Planar Surfaces

Saha

Nairn

Keenan

et al. 2021

Macro Materials & Eng

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Defined structures for tissue engineering can be achieved by a variety of techniques, one of which includes melt-electrowriting (MEW), a technology that deposits spatially defined microfibers of a molten polymer across an electric field. In this study, the authors investigate how to microfabricate biomaterial-meshes using MEW to non-planar surfaces that will have more applicability to anatomical structures. By modeling the electric field strength associated with MEW, it is found that incorporation of a non-conductive 3D printed mould on the conductive collector plate offers the ability to accurately print patterns on non-planar surfaces successfully. Importantly, if the applied voltage at the nozzle or collector plate is kept constant in the MEW process, the electrostatic behavior of the deposited polymer, and the electric field strength between the collector and nozzle (which is greatest at the nozzle) has the greatest impact on the accuracy of fiber patterning and stacking. Consequently, controlled fiber deposition is exhibited, provided that a constant voltage and a constant vertical distance between the nozzle and the mould are maintained. Overall, this study establishes the groundwork to support further developments in MEW technologies, from flat to anatomically relevant 3D structures in the fields of regenerative medicine and biofabrication.

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“…The ability to melt electrowrite candidate polymers is dictated by characteristics such as its molecular weight, melt flow index and thermomechanical properties [10]. Without question, the gold standard polymer for MEW is PCL due to its ease of fabrication, availability (including medical grade standard) and low range of melting temperatures [11]. This relatively soft polymer also renders a flexible scaffold with mechanical properties close to soft biological tissues and non-hazardous in vivo degradation rate [12].…”

Section: Introductionmentioning

confidence: 99%

“…This relatively soft polymer also renders a flexible scaffold with mechanical properties close to soft biological tissues and non-hazardous in vivo degradation rate [12]. MEW process parameters have been extensively investigated with CTS [13], collector speed, collector distance and pressure [14], polymer melt viscosity [10] and nozzle-exit-channel shape [11] all individually having a significant influence on printing and the resultant fibres being collected.…”

Section: Introductionmentioning

confidence: 99%

A deeper insight into the influence of the electric field densities in Melt-Electrowriting: Printing in the 4th Dimension

Nairn¹,

orkeenan@tcd.ie²,

sahau@tcd.ie³

et al. 2021

Preprint

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Defined ordered structures for biomaterials and tissue engineering applications can be achieved by a variety of techniques, one of which includes the electrohydrodynamic (EHD)-based application of melt electrowriting (MEW), the extrusion of a molten polymer filament under pressure across a defined electric field. In this study, we investigate how to translate small fibremeshes which are usually formed on flat surfaces, to curved contours that would have more applicability to human anatomical structures. By modelling the electric field strength associated with the MEW process, we found that incorporation of a non conductive three-dimensional (3D) custom printed mould on the conductive collector plate offers the ability to accurately print patterns on non-flat surfaces successfully. Importantly, while the electric field strength is a constant in the MEW process; the electrostatic behaviour of the deposited polymer has the greatest impact on the accuracy of fibre patterning and stacking. Consequently, controlled fibre deposition was exhibited, provided that a constant electrical field strength and a continuous vertical distance between the nozzle and the mould is maintained.Overall, this study establishes the groundwork to support further developments in MEW technologies, from flat to anatomically relevant 3D structures in the fields of regenerative medicine and biofabrication.

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The effect of nozzle-exit-channel shape on resultant fiber diameter in melt-electrospinning

Cited by 9 publications

References 32 publications

Recent advances in melt electro writing for tissue engineering for 3D printing of microporous scaffolds for tissue engineering

Recent advances in melt electro writing for tissue engineering for 3D printing of microporous scaffolds for tissue engineering

A Deeper Insight into the Influence of the Electric Field Strength When Melt‐Electrowriting on Non‐Planar Surfaces

A deeper insight into the influence of the electric field densities in Melt-Electrowriting: Printing in the 4th Dimension

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