The Effect of NSAIDS and Oral Hypoglycemic Agent on Leukemia and Lymphoma Cell Lines

Abstract

Cancer is regarded as global burden and a serious health challenge. Its occurrences increased due to population aging and the prevalence of risk factors. This study investigated the eff ect of metformin and aspirin on two cell lines SR (diff use large B cell lymphoma) and NB4 (promyelocytic leukemia). The eff ect of metformin as monotherapy on SR was 28.43% viable, while on NB4, only 44.4% were viable. However, the eff ect of aspirin on SR and NB4 cell lines were decreased; the percentage of cell viability were 27.2 and 41.2%, respectively. In conclusion, there is signifi cant eff ect of metformin and aspirin on SR cell line and only mild eff ect on NB4. These may be useful drugs in old diabetic patients with diff use large B cell lymphoma that may reduce the chemotherapy dose