The Effect of Number of Teeth and Chewing Ability on Cognitive Function of Elderly in UAE: A Pilot Study

Seraj, Zahra; Al-Najjar, Dana; Akl, Mohammed A.; Aladle, Noorelrahman; Altijani, Yousif; Zaki, Ahmed; Kawas, Sausan Al

doi:10.1155/2017/5732748

Cited by 23 publications

(20 citation statements)

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“…Tooth loss reflects poor oral health status and reduces chewing ability. Missing teeth [20] and the reduction in the masticatory ability [48,49] can affect cognition, which is consistent with our results.…”

Section: Plos Onesupporting

confidence: 92%

Poor oral health conditions and cognitive decline: Studies in humans and rats

Zhang¹,

Yang²,

Wang³

et al. 2020

PLoS ONE

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Background The relationship between poor oral health conditions and cognitive decline is unclear. Objective To examine the association between oral health and cognition in humans and rats. Methods In humans: a cross-sectional study was conducted. Cognitive levels were evaluated by the Mini Mental State Examination (MMSE); oral conditions were reflected by the number of missing index teeth, bleeding on probing, and probing pocket depth (PD). In rats: a ligatureinduced (Lig) periodontitis model and Aβ 25-35-induced model of Alzheimer's disease (AD) were established; tumor necrosis factor-α (TNF-α), interleukin 1 (IL-1), interleukin 6 (IL-6), and C-reactive protein levels in the hippocampus and cerebral cortex were detected. Results MMSE scores for the number of missing index teeth � 7 group were significantly lower than those in the � 6 group. A negative relationship (correlation coefficient ρ = −0.310, P = 0.002) was observed between MMSE scores and number of missing index teeth. More missing index teeth and lower education levels were independent risk factors for cognitive decline. A negative relationship (correlation coefficient ρ = −0.214, P = 0.031) was observed between MMSE scores and average PD. TNF-α and IL-6 levels in the hippocampus of the Lig+AD group were significantly higher than those of the AD group. IL-1 and IL-6 levels in the cerebral cortex of the Lig+AD group were significantly higher than those of the AD group. Conclusion Poor oral health conditions including more missing index teeth and higher average PD may be risk factors for cognitive decline. Periodontitis may increase inflammatory cytokines in rat models of AD.

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Section: Plos Onesupporting

confidence: 92%

Poor oral health conditions and cognitive decline: Studies in humans and rats

Zhang¹,

Yang²,

Wang³

et al. 2020

PLoS ONE

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“…Evidence has shown that tooth loss is not only associated with oral health, but also with systemic health [ 6 ]. Recently, increasing studies have focused on the link between tooth loss and the risk of dementia [ 7 – 12 ]. There are several potential mechanisms by which tooth loss can negatively impact cognitive function.…”

Section: Introductionmentioning

confidence: 99%

Tooth loss as a risk factor for dementia: systematic review and meta-analysis of 21 observational studies

Fang

Jiang

et al. 2018

BMC Psychiatry

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BackgroundTooth loss is suggested to be associated with an increased risk of dementia in many studies. But the relationship between tooth loss and dementia is not yet fully understood. This systematic review and meta-analysis aimed to determine the relative effect of tooth loss on dementia risk.MethodsAn electronic search of PubMed, Scopus, Embase, and Web of Knowledge was conducted in March 2018 to identify relevant observational studies with the English language restriction. Studies were included if they assessed the relationship between tooth loss and risk of dementia. Study quality was detected by the modified Downs and Black scale. Odds risks (ORs) were pooled using a random-effects model in the crude model.ResultsThe literature search initially yielded 1574 articles, and 21 observational studies published between 1994 and 2017 were finally included for the analyses. The crude results with random-effects model showed that patients with multiple tooth loss had higher incidence of dementia (OR 2.62, 95% CI 1.90–3.61, P < 0.001, I2 = 90.40%). The association remained noted when only adjusted results were pooled from 18 studies (OR 1.55, 95% CI 1.41–1.70, P = 0.13, I2 = 28.00%). Meta-regression analysis showed that study design explained about 16.52% of heterogeneity in the crude model. The overall quality rating scores of studies ranged from 11 to 16.ConclusionsFindings from this review evidenced that tooth loss is positively associated with an increased risk of dementia in adults. Future well-designed longitudinal researches examining the direct and indirect relationship between tooth loss and dementia risk are encouraged.Electronic supplementary materialThe online version of this article (10.1186/s12888-018-1927-0) contains supplementary material, which is available to authorized users.

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“…concludes that there is increased cognitive capacity and memory retrieval in elderly people having good chewing efficiency. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

Influence of Dental Prostheses on Cognitive Functioning in Elderly Population: A Systematic Review

Ahmed

Mohan

Kalaignan

et al. 2021

Journal of Pharmacy and Bioallied Sciences

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Aim: The aim of the systematic review was to assess the influence of dental prostheses on cognitive functioning in elderly population. Materials and Methods: This systematic review was conducted according to the PRISMA guidelines. The initial electronic search was conducted using the following search databases: MEDLINE (PubMed), Cochrane Library, Google Scholar, and EMBASE. The search was limited to English language using the search items/keywords: “dental prostheses and cognitive functioning,” “dental prostheses and brain function,” “Tooth loss and cognitive loss,” “mastication and prefrontal activity,” and “prostheses on mental state.” The search strategy was followed using the PICOS framework. Results: A total of 19 studies were selected according to the selection criteria. Out of 19 studies, 15 studies were included and 4 studies were excluded from the review. Conclusion: With the available evidence in the literature, it can be concluded that dental prostheses have a very significant role in preventing the cognitive impairment and act as a protective factor in enhancing the cognitive function in patients with dementia-related diseases and neurodegenerative diseases.

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The Effect of Number of Teeth and Chewing Ability on Cognitive Function of Elderly in UAE: A Pilot Study

Cited by 23 publications

References 58 publications

Poor oral health conditions and cognitive decline: Studies in humans and rats

Poor oral health conditions and cognitive decline: Studies in humans and rats

Tooth loss as a risk factor for dementia: systematic review and meta-analysis of 21 observational studies

Influence of Dental Prostheses on Cognitive Functioning in Elderly Population: A Systematic Review

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