The effect of obesity on patients with mild chronic obstructive pulmonary disease: results from KNHANES 2010 to 2012

Park, Ju Hee; Lee, Jung Kyu; Heo, Eun Young; Kim, Deog Kyeom; Chung, Hee Soon

doi:10.2147/copd.s126192

Cited by 15 publications

(14 citation statements)

References 41 publications

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“…Out of the 23 obese patients, only 5 (21.73%) were diagnosed with severe COPD (FEV1s <30% of predicted value). These results are consistent with the currently available international epidemiological data (Park et al, 2017). Obesity represents a major health problem, with an impact on the pathophysiology of respiration, in obesity-hypoventilation syndrome, or in obesity-COPD overlap syndrome.…”

Section: Discussionsupporting

confidence: 91%

Untitled

2018

Pm3

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Section: Discussionsupporting

confidence: 91%

Untitled

2018

Pm3

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“…24 Lastly, the mechanical restriction imposed by obesity that is prevalent in this group, may obscure the finding of reduced FEV 1 /FVC ratio. 25 In the present study, we also examined individuals without a label of COPD but showed moderate nonobstructive impairment on spirometry. This group was equally prevalent as undiagnosed COPD and have been increasingly reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and burden of COPD misclassification in the Canadian Longitudinal Study on Aging (CLSA)

et al. 2022

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IntroductionTo examine the prevalence of chronic obstructive pulmonary disease (COPD) misclassification and the associated burden of symptoms, healthcare utilisation and physical performance status in the Canadian general population. This information is presently lacking from large population-based studies with high-quality spirometry data that can be generalised to the general population.MethodsThe prevalence of self-reported physician-diagnosed COPD and the concordance with spirometry airflow obstruction (AO) were assessed in a cross-sectional cohort of Canadian older adults. The associations between confirmed COPD, under-diagnosis and over-diagnosis with self-reported respiratory symptoms, healthcare utilisation and physical performance (timed up and go, handgrip strength and 4 metres walk test) were assessed, adjusting for baseline characteristics using multivariable linear and logistic models.ResultsA total of 21 242 participants (mean age 64 (SD 10) years; 42% men) with high quality spirometry were included. Physician-diagnosed COPD was reported in (n=973) 5% of the participants. Only (n=217) 1% of the entire cohort had confirmed COPD supported by spirometry AO. Discordance between self-reported COPD and spirometry findings was observed in (n=1565) 8%: with 4% representing under-diagnosis cases (no self-reported COPD but AO) and 4% representing over-diagnosis cases (self-reported COPD but no AO). Compared with normals (no self-reported COPD and normal spirometry), those with confirmed, under-diagnosed or over-diagnosed COPD showed higher risks for respiratory symptoms (adjusted OR (aOR) 2.1 (95% CI: 1.6 to 2.7); aOR 1.8 (95% CI: 1.6 to 2.1]; aOR 1.6 (95% CI: 1.4 to 1.9)); healthcare utilisation in the prior 12 months (β coefficient 0.8 (95% CI: 0.2 to 2.6); β 0.9 (95% CI: 0.5 to 1.5); β 1.6 (95% CI: 0.7 to 4.0)). Mood disorders were higher in confirmed and over-diagnosed COPD (aOR 1.7 (95% CI: 1.3 to 2.4); 1.7 (95% CI: 1.4 to 2.0), respectively). Physical performance was lower for COPD groups.ConclusionsThe prevalence of COPD misclassification is high in the general population of older adults. These were associated with significantly high burden of respiratory symptoms, healthcare utilisation and low physical performance compared with the general population with normal spirometry and no self-reported COPD. These findings highlight the high burden of COPD misclassification, which may be substantially reduced with greater accessibility to spirometry measurements in the community.

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“…Even if little is known about the prevalence and impact of COPD in patients with the metabolic syndrome and/or obesity, because lung function is seldom measured in these patients, the observation that obese patients with mild COPD had more comorbid conditions suggesting that obesity and COPD may be a risk 69,70 .…”

Section: Metabolic Diseasesmentioning

confidence: 99%

Chronic Respiratory Abnormalities in the Multi-Morbid Frail Elderly

Beghè¹,

Clini²,

Fabbri³

2017

BRN

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Two-thirds of people aged ≥65 years have multi-morbidity. Multi-morbidity includes both physical and mental health conditions, as anxiety and depression, that almost invariably affect patients with multiple symptomatic chronic diseases. Management of a patient with any of the chronic diseases that are part of multi-morbidity is not just the management of that single index disease, but must include the active search and proper treatment of concomitant chronic diseases. The presence of concomitant chronic diseases should not alter the management of the index disease (e.g., chronic obstructive pulmonary disease [COPD]), and concomitant chronic diseases should be treated according to single diseases guidelines regardless of the presence of the index disease, obviously with careful consideration that this choice implies complex management, polypharmacy and potential adverse effects. Preliminary management programs suggest that a holistic integrated approach might improve quality of life and reduce hospital admissions and death in these multimorbid patients. (BRN Rev. 2017;3:247-66)

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The effect of obesity on patients with mild chronic obstructive pulmonary disease: results from KNHANES 2010 to 2012

Cited by 15 publications

References 41 publications

Untitled

Untitled

Prevalence and burden of COPD misclassification in the Canadian Longitudinal Study on Aging (CLSA)

Chronic Respiratory Abnormalities in the Multi-Morbid Frail Elderly

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