The Effect of Obesity Surgery on Obesity Comorbidity

Bouldin, Marshall J.; Ross, Leigh Ann; Sumrall, Caryl D.; Loustalot, Fleetwood; Low, Annette K.; Land, Kelly K.

doi:10.1097/00000441-200604000-00004

Cited by 65 publications

(40 citation statements)

References 113 publications

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“…In recent years, bariatric surgical procedures have been increasingly used for the treatment of severe obesity. These procedures combine gastric restriction and/or intestinal bypass to induce early satiety and nutrient malabsorbtion, respectively (35,(169)(170)(171)(172), and lead to an approximately 60% loss in excess body weight in the first 12 to 18 months postoperatively (173)(174)(175)(176)(177)(178)(179)(180)(181)(182)(183)(184)(185). In a recent meta-analysis of bariatric studies involving 22,094 patients, Buchwald and colleagues (11) Improvements in sleep apnea with weight loss have been related to effects of adiposity on upper airway function during sleep.…”

Section: Weight Loss Sleep Apnea and Upper Airway Functionmentioning

confidence: 99%

Obesity and Obstructive Sleep Apnea: Pathogenic Mechanisms and Therapeutic Approaches

Schwartz

Patil²,

Laffan

et al. 2008

Proceedings of the American Thoracic Society

584

395

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Obstructive sleep apnea is a common disorder whose prevalence is linked to an epidemic of obesity in Western society. Sleep apnea is due to recurrent episodes of upper airway obstruction during sleep that are caused by elevations in upper airway collapsibility during sleep. Collapsibility can be increased by underlying anatomic alterations and/or disturbances in upper airway neuromuscular control, both of which play key roles in the pathogenesis of obstructive sleep apnea. Obesity and particularly central adiposity are potent risk factors for sleep apnea. They can increase pharyngeal collapsibility through mechanical effects on pharyngeal soft tissues and lung volume, and through central nervous system-acting signaling proteins (adipokines) that may affect airway neuromuscular control. Specific molecular signaling pathways encode differences in the distribution and metabolic activity of adipose tissue. These differences can produce alterations in the mechanical and neural control of upper airway collapsibility, which determine sleep apnea susceptibility. Although weight loss reduces upper airway collapsibility during sleep, it is not known whether its effects are mediated primarily by improvement in upper airway mechanical properties or neuromuscular control. A variety of behavioral, pharmacologic, and surgical approaches to weight loss may be of benefit to patients with sleep apnea, through distinct effects on the mass and activity of regional adipose stores. Examining responses to specific weight loss strategies will provide critical insight into mechanisms linking obesity and sleep apnea, and will help to elucidate the humoral and molecular predictors of weight loss responses.

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Section: Weight Loss Sleep Apnea and Upper Airway Functionmentioning

confidence: 99%

Obesity and Obstructive Sleep Apnea: Pathogenic Mechanisms and Therapeutic Approaches

Schwartz

Patil²,

Laffan

et al. 2008

Proceedings of the American Thoracic Society

584

395

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“…70,73,74 In fact, in severely obese individuals, the prevalence ranges from 55% to 100%. 75,76 In addition, obese individuals often have more severe disease, as manifested by a higher AHI and lower nadir on nocturnal pulse oximetry. 70,77,78 Several studies have demonstrated that weight loss, even a modest amount, can effectively manage OSA.…”

Section: Obstructive Sleep Apnea: the Effect Of Bariatric Surgerymentioning

confidence: 99%

Biological effects of bariatric surgery on obesity-related comorbidities

2013

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“…A technique that combines the reduction of the reservoir and restricting gastric emptying by a ring -known as Roux-en-Y gastricjejunal bypass -, is today the most used in the Brazilian Unified Health System (SUS) 49 . The number of operations for obesity has increased in recent years 5,47 and its success is founded on the effective weight loss, control of comorbidities and increased quality of life 1,5,9,29,47 . However, some negative effects have also been reported in several studies, such as hyperparathyroidism and osteoporosis 39,55,57,59 chronic regurgitation, nutritional deficiencies 2,6,28,30,59 , kidney problems 3,16 and oral problems 22,23,31,49 .…”

Section: Introductionmentioning

confidence: 99%

Consequências sistêmicas da cirurgia bariátrica e suas repercussões na saúde bucal

Moura-Grec

Assis

Cannabrava

et al. 2012

ABCD, arq. bras. cir. dig.

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-Introduction -Morbid obesity control can be done by bariatric surgery that restricts or reduces the amount of food absorption. The objective of this review was to identify the consequences of bariatric surgery and its repercussions on oral health. Method -It was used the Virtual Library of Health, which included articles that had any direct or indirect connection between bariatric surgery and oral health, and published in the last ten years. Results -Some complications of the surgery are chronicle reflux and nutritional deficiency, which may bring repercussions on the oral cavity, such as tooth erosion, bone loss and dental caries. On the other hand, there are also positive impacts, such as the decrease of diabetes, apnea and improvement on self-esteem, that makes the patients less vulnerable to complications regarding oral health, for example xerostomy and periodontal disease. Conclusion -Maintaining proper oral health in patients undergoing bariatric surgery contributes to success after surgery protecting benefits and minimizing side effects. ABCDDV/868RESUMO -Introdução -O controle da obesidade mórbida pode ser realizado através da cirurgia bariátrica que leva à restrição e/ou à má-absorção de alimentos. O objetivo dessa revisão foi identificar consequências desse procedimento e suas repercussões na saúde bucal. Método -Foi realizada busca na Biblioteca Virtual em Saúde, sendo incluídos artigos com relação direta ou indireta entre cirurgia bariátrica e saúde bucal e publicados nos últimos dez anos. Resultados -Verificaram-se algumas complicações decorrentes dessa operação, como regurgitação crônica e deficiências nutricionais, que podem trazer repercussões na cavidade bucal como erosão dentária, perda óssea e cárie dentária. Por outro lado, existem consequências positivas como controle da diabetes, da apnéia e melhora da auto-estima, que tornam os pacientes menos susceptíveis à complicações na cavidade oral, como xerostomia e doença periodontal. Conclusão -A manutenção da saúde bucal adequada em pacientes submetidos à cirurgia bariátrica contribui para o sucesso após a operação, resguardando os benefícios e minimizando os efeitos colaterais.

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The Effect of Obesity Surgery on Obesity Comorbidity

Cited by 65 publications

References 113 publications

Obesity and Obstructive Sleep Apnea: Pathogenic Mechanisms and Therapeutic Approaches

Obesity and Obstructive Sleep Apnea: Pathogenic Mechanisms and Therapeutic Approaches

Biological effects of bariatric surgery on obesity-related comorbidities

Consequências sistêmicas da cirurgia bariátrica e suas repercussões na saúde bucal

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