During the COVID-19 pandemic in early 2020, domestic violence, interpersonal conflicts, and cyberbullying have risen sharply in China. We speculate that the perceived threat of COVID-19 is related to a general, non-target-specific aggressive tendency during the pandemic. We surveyed 1556 Chinese people in April 2020 (757 people in Hubei Province, the pandemic epicenter in China, and 799 in other regions of China where the pandemic is relatively not severe). A multiple-group structural equation modeling analysis found significant total effects between perceived threat of COVID-19 and aggressive tendencies during the pandemic in both regional groups, and the effect between them was mainly achieved through the mediating roles of sense of control and powerlessness during the pandemic. For all participants, negative coping strategies significantly aggravated the association between perceived threat of COVID-19 and aggressive tendencies during the pandemic, but the buffers were different across regions of outbreak severity. For participants in other regions where the pandemic is relatively not severe, positive coping strategies could mitigate the association between perceived threat of COVID-19 and aggressions. However, for participants in Hubei Province, the epicenter of China's pandemic, higher life satisfaction was more effective in buffering. These findings extend the possible consequences of the perceived COVID-19 threat and suggest that improving the life satisfaction of residents in areas with severe outbreaks is more effective in mitigating the adverse effects of COVID-19.Keywords COVID-19 . Perceived threat . Aggression . Mediator . ModeratorThe novel coronavirus disease (COVID-19) pandemic that has swept the world since December 2019 is the most serious public health crisis since World War II (Guterres, 2020). This study paid particular attention to a prominent phenomenon during the pandemic in China: the rising aggressive tendencies among Chinese people. During the COVID-19 pandemic, people in China seemed to become restless. Domestic violence, interpersonal conflicts, and cyberbullying have risen sharply in the pandemic period (Global Times, 2020;Li et al., 2020;Ye et al., 2020). These aggressions may instigate social tensions and increase the level of social conflicts in the post-pandemic period (Censolo & Morelli, 2020). Therefore,