The effect of occupational chronic lead exposure on the complete blood count and the levels of selected hematopoietic cytokines

Chwalba, Artur; Maksym, Beata; Dobrakowski, Michał; Kasperczyk, Sławomir; Pawlas, Natalia; Birkner, Ewa; Kasperczyk, Aleksandra

doi:10.1016/j.taap.2018.05.034

Cited by 31 publications

(16 citation statements)

References 24 publications

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“…On the other hand, a significant rise in ZPP in the exposed group indicated the disturbance in the final step of heme biosynthesis. This finding is in agreement with the results of other studies (14).…”

Section: Discussionsupporting

confidence: 94%

“…Lead generally inhibits the delta-aminolevulinic acid dehydratase activity, which enhances ALA in blood plasma and urine, and it is considered the most sensitive biomarker for the adverse effects of lead exposure. It should be noted that heme biosynthesis in the human body is not decreased until ALAD activity is largely inhibited (8,14). On the other hand, a significant rise in ZPP in the exposed group indicated the disturbance in the final step of heme biosynthesis.…”

Section: Discussionmentioning

confidence: 94%

“…In Press(In Press):e95917. eases and PbB levels, but some of the relationships have not posed this association (8,14,(22)(23)(24)(25)(26)(27). Therefore, in the present matched case-control study, the occupational and biological exposures to lead were assessed to examine the association of occupational PbB levels with hematological parameters and kidney function in mine workers.…”

Section: Discussionmentioning

confidence: 96%

“…All red cell indices are useful to evaluate the etiology of anemia. Anemia is defined as a low level of hemoglobin and is related to a reduced HTC value, which is defined as the ratio of red blood cell volume to the total blood volume (14,32).…”

Section: Discussionmentioning

confidence: 99%

“…Also, lead can shorten the lifespan of red blood cells (RBCs) and subsequently increase the risk of reticulocytosis and anemia (12,13). Although chronic exposure to lead can affect the complete blood count (CBC), the effectiveness of using these para-clinical markers in the evaluation of occupational diseases caused by lead exposure has not been well known (14,15).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Blood Lead Levels and Their Effects on Hematological Parameters and Renal Function in Iranian Lead Mine Workers

et al. 2020

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Background: Lead toxicity has become a growing health concern in countries such as Iran. However, little information is available on the assessment and evaluation of the health effects of lead exposure in mine workers. Objectives: The present study assessed the occupational exposure to lead and examine the association of blood lead (PbB) levels with hematological and kidney function parameters in mine workers. Methods: In this matched case-control study, the level of PbB was measured in 100 workers (70 exposed and 30 non-exposed), and then its relationship was evaluated with complete blood count (CBC) parameters, zinc protoporphyrin (ZPP), urea, blood creatinine levels, urinary δ-aminolevulinic acid (ALA), coproporphyrin, and creatinine levels. Results: The results showed a linear and significant relationship between the PbB level and B-ZPP, U-ALA, U-coproporphyrin, and U-creatinine levels in states of PbB levels > 20 μg/dL in a time and dose-dependent manner. A significant relationship was observed between the PbB level and the years of occupational exposure to lead and the B-urea level (P-value < 0.03). Conclusions: Chronic occupational exposure to lead decreased hematocrit, RDW-CV, MCV, MCH, and HGB values but did not significantly change RBC counts. Therefore, a regular assessment of routine blood parameters (such as CBC and ZPP) and renal function indices can be effectively used to monitor the toxic effects of lead exposure.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Blood Lead Levels and Their Effects on Hematological Parameters and Renal Function in Iranian Lead Mine Workers

et al. 2020

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SIRT1/mTOR pathway‐mediated autophagy dysregulation promotes Pb‐induced hepatic lipid accumulation in HepG2 cells

Mao

Zhang

Guan

et al. 2021

Environmental Toxicology

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Lead (Pb) is a common and toxic metal pollutant in the ecological environment and has drawn significant attention due to its presence in various channels, including the use of lead‐based paint, mineral extraction and smelting, exhaust gas from gasoline combustion. Autophagy is an essential catabolic pathway and blocked autophagy may result in abnormal lipid metabolism in liver. A body of evidence demonstrates that Pb exposure causes abnormal lipid droplet (LDs) accumulation in the liver, but the mechanism remains unknown. Here, we investigated whether Pb induced lipid accumulation by regulating autophagy in HepG2 cells. In this study, we found that Pb (50 μM) blocked the autophagy flux mainly by transcription factor EB (TFEB)‐mediated impairment of lysosome formation and activity. Then we demonstrated that the dense lipid accumulation was observed upon Pb exposure, and induction of autophagy by the autophagy activator rapamycin (Rap) alleviated Pb‐induced lipid accumulation, while suppression of autophagy by chloroquine (CQ) exacerbated Pb‐induced lipid accumulation, suggested that Pb‐induced autophagy blockage might be responsible for lipid accumulation. Moreover, we demonstrated that the SIRT1/mTOR pathway participated in Pb‐induced autophagy dysregulation, leading to Pb‐induced hepatic lipid accumulation. In summary, these results revealed a new insight into the relationship between Pb‐caused autophagy dysregulation and lipid accumulation for the first time and highlight autophagy as a novel therapeutic target against Pb‐induced hepatic lipid accumulation which supplying the theoretical basis and potential strategies for the intervention and treatment of Pb‐related disease.

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Lead Pollution and Human Exposure: Forewarned is Forearmed, and the Question Now Becomes How to Respond to the Threat!

Natasha

Dumat

Shahid

et al. 2019

Radionuclides and Heavy Metals in the Environment

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The effect of occupational chronic lead exposure on the complete blood count and the levels of selected hematopoietic cytokines

Cited by 31 publications

References 24 publications

Evaluation of Blood Lead Levels and Their Effects on Hematological Parameters and Renal Function in Iranian Lead Mine Workers

Evaluation of Blood Lead Levels and Their Effects on Hematological Parameters and Renal Function in Iranian Lead Mine Workers

SIRT1/mTOR pathway‐mediated autophagy dysregulation promotes Pb‐induced hepatic lipid accumulation in HepG2 cells

Lead Pollution and Human Exposure: Forewarned is Forearmed, and the Question Now Becomes How to Respond to the Threat!

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