The Effect of Octreotide on Peritoneal Alterations Induced by High Concentration of Glucose

Effects of Interferon‐α‐2b and Octreotide on Healing of Esophageal Corrosive Burns

“…As we refer to the literature, we can see that antifibrotic and antiproliferative effects have been observed in humans, such as considerable decrease of fibrosis in patients undergoing peritoneum dialysis and lessening of the heart muscle mass in cardiomyopathy treatment. 10,22 Octreotide (and interferon treatment) has more advantages than many treatment strategies offered in the literature for the treatment of esophagus burns. It is a noninvasive treatment method, with minimum contraindications and good tolerability constituting superiority over the dilatation method and other many methods.…”

Peritoneal Sclerosis: One or Two Nosological Entities?

“…Intraperitoneal administration of octreotide, a somatostatin analogue that inhibits release of growth hormone, was found to have a protective effect on SP in a rat model (265). In another study the intraperitoneal administration of glycosaminoglycans prevented the functional and morphologic peritoneal derangement of plasticizer-induced peritoneal fibrosis in rats (266).…”

Diagnosis and Management of Encapsulating Peritoneal Sclerosis

“…Because TGFβ stimulates extracellular matrix production, there is speculation that TGFβ is likely to play a causative role in the development of subsequent sclerosis. In several small studies or case reports, cytokine blockers such as octreotide have protected against peritoneal sclerosis (7), suggesting that the profibrogenic cytokine profile observed in peritoneal dialysate following peritonitis may contribute significantly to the sclerotic process.…”

“…In several small studies or case reports, cytokine blockers such as octreotide have protected against peritoneal sclerosis (7), suggesting that the profibrogenic cytokine profile observed in peritoneal dialysate following peritonitis may contribute significantly to the sclerotic process.…”