The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence

Jackson, Sonia; James, Mark; Abrams, Paul

doi:10.1111/j.1471-0528.2002.01052.x

Cited by 168 publications

(86 citation statements)

References 32 publications

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“…An alternative explanation for the similar tendon CSA between groups could be that ERT also increases tendon collagen breakdown. This possibility is supported by findings in other types of collagen-rich tissues, where estrogen administration was linked to indications of a higher tendon collagen turnover and a more immature tendon structure (15,26). Nevertheless, fibril characteristics showed no significant differences in mean fibril area or density between the two groups in the present study.…”

Section: Tendon Csa and Fibril Characteristicssupporting

confidence: 77%

“…Tendon dialysate was similarly analyzed for PINP for indirect quantification of local synthesis of CTX-I in tendon. The analysis for PINP was performed using a sandwich ELISA utilizing purified ␣ 1-chain specific rabbit antibodies (donated by B. Teisner, Department of Medical Microbiology, University of Southern Denmark, Odense, Denmark) (26). The within-(double determination) and between-assay CVs were, on average, 2.2 and 4.9%, respectively.…”

Section: Experimental Protocol and Methodsmentioning

confidence: 99%

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Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women

Hansen

Kongsgaard²,

Holm³

et al. 2009

Journal of Applied Physiology

121

114

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Flyvbjerg A, Langberg H, Kjaer M. Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women. J Appl Physiol 106: 1385-1393, 2009. First published October 16, 2009 doi:10.1152/japplphysiol.90935.2008.-The knowledge about the effect of estradiol on tendon connective tissue is limited. Therefore, we studied the influence of estradiol on tendon synthesis, structure, and biomechanical properties in postmenopausal women. Nonusers (control, n ϭ 10) or habitual users of oral estradiol replacement therapy (ERT, n ϭ 10) were studied at rest and in response to one-legged resistance exercise. Synthesis of tendon collagen was determined by stable isotope incorporation [fractional synthesis rate (FSR)] and microdialysis technique (NH2-terminal propeptide of type I collagen synthesis). Tendon area and fibril characteristics were determined by MRI and transmission electron microscopy, whereas tendon biomechanical properties were measured during isometric maximal voluntary contraction by ultrasound recording. Tendon FSR was markedly higher in ERT users (P Ͻ 0.001), whereas no group difference was seen in tendon NH2-terminal propeptide of type I collagen synthesis (P ϭ 0.32). In ERT users, positive correlations between serum estradiol (sestradiol) and tendon synthesis were observed, whereas change in tendon synthesis from rest to exercise was negatively correlated to s-estradiol. Tendon area, fibril density, fibril volume fraction, and fibril mean area did not differ between groups. However, the percentage of medium-sized fibrils was higher in ERT users (P Ͻ 0.05), whereas the percentage of large fibrils tended to be greater in control (P ϭ 0.10). A lower Young's modulus (GPa/%) was found in ERT users (P Ͻ 0.05). In conclusion, estradiol administration was associated with higher tendon FSR and a higher relative number of smaller fibrils. Whereas this indicates stimulated collagen turnover in the resting state, collagen responses to exercise were negatively associated with s-estradiol. These results indicate a pivotal role for estradiol in maintaining homeostasis of female connective tissue. connective tissue; tendon fibrils; insulin-like growth factor-I; extracellular matrix; bone CROSS-SECTIONAL FINDINGS INDICATE that sex hormones influence tendon biomechanical properties (36), extracellular matrix adaptability in response to mechanical loading (11,21,36,41,59), and the risk of sustaining soft tissue injuries (11,24,25).Estrogen receptors have been localized in ligaments (32, 33), and tendons express transcripts for estrogen receptors (23). Nevertheless, the effect of estrogen on tendon and ligament turnover is not clarified. Thus an inhibiting effect (34, 60), no effect (51), and a stimulating effect (32) on collagen synthesis and fibroblast proliferation in vitro have been observed in anterior cruciate ligament (ACL) tissue samples. These contrasting findings are probably related to the variation between animal species and the applied methods. This ...

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Section: Tendon Csa and Fibril Characteristicssupporting

confidence: 77%

Section: Experimental Protocol and Methodsmentioning

confidence: 99%

Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women

Hansen

Kongsgaard²,

Holm³

et al. 2009

Journal of Applied Physiology

121

114

View full text Add to dashboard Cite

show abstract

“…(13) The role of estradiol in target tissues in the lower urinary tract remains unclear. It has been postulated that estrogen may increase loose connective tissue and/or stimulate collagen degradation in the pelvic and urethral tissue [17,24,25]. It could be speculated that this could result in an increased hypermobility of the bladder neck and the paraurethral tissue leading to an impaired urethral closure function [13].…”

Section: Commentsmentioning

confidence: 99%

Serum estradiol does not differentiate stress, mixed and urge incontinent women around menopause. A report from the Women's Health in the Lund Area (WHILA) study

Hamer

Källén

Lidfeldt

et al. 2011

European Journal of Obstetrics & Gynecology and Reproductiv

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Serum estradiol does not differentiate stress, mixed and urge incontinent women around menopause. A report from the Women's Health in the Lund Area (WHILA) study.Andrada, Maria; Källén, Karin; Lidfeldt, Jonas; Samsioe, Göran; Teleman, Pia General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. To outline serum estradiol levels in perimenopausal women with stress, mixed or urge incontinence. We believe the majority of urgency symptoms in perimenopausal women to be caused by a pelvic floor dysfunction and a hypermobility of the bladder neck. If this is the case, there would be no difference in estradiol levels between the groups. Study design:Setting: university hospital. In the observational Women´s Health In the Lund Area study, a subset of 400/2221 women reporting urinary incontinence completed a detailed questionnaire regarding lower urinary tract symptoms and had their serum steroid hormone levels measured.Statistical analyses were made by Chi-square test, nonparametrical tests, ANOVA, multi-and univariate logistic regression analysis. Results:Stress incontinence was reported by 196, mixed incontinence by 153 and urge incontinence by 43 women. Serum estradiol did not differ significantly between stress incontinent (median 49.5 pmo/l, range 2.63-875.4), urge incontinent ( median 31.6 pmol/l, range 2.63-460.7) or mixed incontinent women ( median 35.5 pmol/l, range 2.63-787.9, p = 0.62). Logistic regression analysis correcting for age, parity, hormonal status, smoking, hysterectomy and BMI also failed to show any difference in estradiol levels between the groups (p=0.41-0.58). Conclusion:No significant differences in serum estradiol levels between stress, mixed or urge incontinent perimenopausal women could be demonstrated . 4Keywords:Female urinary incontinence; mixed urinary incontinence; serum estradiol; stress urinary incontinence; urge urinary incontinence.5

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“…This decreases urethral closure pressure, i.e. the positive pressure in the urethra during bladder filling, and so increases the likelihood of incontinence (Jackson et al, 2002;DuBeau, 2005).…”

Section: Muscles Of the Urethramentioning

confidence: 99%

The physiological function of lower urinary tract smooth muscle

Fry

Meng

Young

2010

Autonomic Neuroscience

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The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence

Cited by 168 publications

References 32 publications

Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women

Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women

Serum estradiol does not differentiate stress, mixed and urge incontinent women around menopause. A report from the Women's Health in the Lund Area (WHILA) study

The physiological function of lower urinary tract smooth muscle

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