1936
DOI: 10.1210/endo-20-4-473
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The Effect of Oestrogenic Hormone on Experimental Pancreatic Diabetes in the Monkey1

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Cited by 31 publications
(6 citation statements)
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“…In 1928, the improvement of glycemic control through injections of estrogenic substances (estrin) in women with DM was reported [ 11 ]. After that, the improvement of glycemic control and the extension of life span was observed in pancreatectomized diabetic dogs [ 1 ] and monkeys [ 12 ] treated with estrogen. Additionally, the estrogen-induced improvement of glycemic control was reported in women who developed diabetes related to menopause or ovariectomy [ 13 ].…”
Section: Early History Of Dm Estrogen and Their Relationshipmentioning
confidence: 99%
“…In 1928, the improvement of glycemic control through injections of estrogenic substances (estrin) in women with DM was reported [ 11 ]. After that, the improvement of glycemic control and the extension of life span was observed in pancreatectomized diabetic dogs [ 1 ] and monkeys [ 12 ] treated with estrogen. Additionally, the estrogen-induced improvement of glycemic control was reported in women who developed diabetes related to menopause or ovariectomy [ 13 ].…”
Section: Early History Of Dm Estrogen and Their Relationshipmentioning
confidence: 99%
“…The following results have been observed in totally pancreatectomized animals treated with oestrogens; (a) attenuation of diabetes in dogs (Barnes and Regan, 1933;Barnes, Regan, and Nelson, 1933) and monkeys (Nelson and Overholser, 1936); (b) no effect in the monkey (Collip, Selye, and Neufeld, 1937) and dogs (Young, 1941); and (c) increase in severity of diabetes in the ferret (Dolin, Joseph, and Gaunt, 1941) and in rats (Martinez, unpublished results).…”
Section: Castration and Restitutionmentioning
confidence: 97%
“…In animal studies the main steroids of the ovary, the estrogens and the progestins, have been shown to provide a protective influence to the susceptibility to experimental diabetes (7,8). Furthermore, an increase in basal glycemia and impaired glucose tolerance have been observed in ovariectomized mice as well as rats and steroid replacement experiments then indicated that a deficiency of estrogens is mainly responsible for the deterioration of glucose tolerance (9,10).…”
Section: Introductionmentioning
confidence: 99%