The effect of oil components on the physicochemical properties and drug delivery of emulsions: Tocol emulsion versus lipid emulsion

Hung, Chi Feng; Fang, Chia Lang; Liao, Ming‐Feng; Fang, Jia You

doi:10.1016/j.ijpharm.2006.11.016

Cited by 71 publications

(43 citation statements)

References 32 publications

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“…Nanoemulsions and control solution were evaluated for a period of 285 h. A maximum resveratrol release of approximately 57% was observed for both nanoemulsions E (with PFPE) and F (without PFPE), and a maximum resveratrol release of approximately 70% was observed for the free resveratrol control ( Figure 2B, black curve). Resveratrol nanoemulsion release profiles are consistent with Hung et al, who reported up to 55% resveratrol release from a nanoemulsion containing coconut oil and vitamin E [43]. These data suggest that the resveratrol release from the nanoemulsion is not affected by the presence of PFPE (verified using one-way ANOVA, p > 0.05).…”

Section: Resveratrol Loading and Release Studiessupporting

confidence: 89%

Development and Characterization of Resveratrol Nanoemulsions Carrying Dual-Imaging Agents

et al. 2016

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Aim: Delivery of the natural anti-inflammatory compound resveratrol with nanoemulsions can dramatically improve its tissue targeting, bioavailability and efficacy. Current assessment of resveratrol delivery efficacy is limited to indirect pharmacological measures. Molecular imaging solves this problem. Results/methodology: Nanoemulsions containing two complementary imaging agents, near-infrared dye and perfluoropolyether (PFPE), were developed and evaluated. Nanoemulsion effects on macrophage uptake, toxicity and NO production were also evaluated. The presence of PFPE did not affect nanoemulsion size, zeta potential, colloidal stability, drug loading or drug release. Conclusion: PFPE nanoemulsions can be used in future studies to evaluate nanoemulsion biodistribution without interfering with resveratrol delivery and pharmacological outcomes. Developed nanoemulsions show promise as a versatile treatment strategy for cancer and other inflammatory diseases.

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Section: Resveratrol Loading and Release Studiessupporting

confidence: 89%

Development and Characterization of Resveratrol Nanoemulsions Carrying Dual-Imaging Agents

et al. 2016

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“…38 In this way, nanoemulsion systems improve the bioavailability of many topical preparations. 25,26 Droplet size analysis in this study showed that the formulations had a small droplet size in the range desirable for a nanoemulsion. 37 Addition of a rheological modifier greatly affected the droplet size in our trial nanoemulsions via two mechanisms.…”

Section: Droplet Sizementioning

confidence: 63%

“…The free radical scavenging activity of the extract released into the receptor compartment solution was evaluated using stable radical DPPH 26 with slight modification. A 200 µL sample of the receptor solution was added to 2.5 mL of distilled water with 100 µL of 0.04% w/v DPPH in 99.7 ethanol at 26°C ± 2°C.…”

Section: In Vitro Radical Scavenging Activity Of the Extract Releasedmentioning

confidence: 99%

Formulation and in vitro release evaluation of newly synthesized palm kernel oil esters-based nanoemulsion delivery system for 30% ethanolic dried extract derived from local Phyllanthus urinaria for skin antiaging

Mahdi¹,

Noor²,

Sakeena³

et al. 2011

IJN

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Background Recently there has been a remarkable surge of interest about natural products and their applications in the cosmetic industry. Topical delivery of antioxidants from natural sources is one of the approaches used to reverse signs of skin aging. The aim of this research was to develop a nanoemulsion cream for topical delivery of 30% ethanolic extract derived from local Phyllanthus urinaria ( P. urinaria ) for skin antiaging. Methods Palm kernel oil esters (PKOEs)-based nanoemulsions were loaded with P. urinaria extract using a spontaneous method and characterized with respect to particle size, zeta potential, and rheological properties. The release profile of the extract was evaluated using in vitro Franz diffusion cells from an artificial membrane and the antioxidant activity of the extract released was evaluated using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method. Results Formulation F12 consisted of wt/wt, 0.05% P. urinaria extract, 1% cetyl alcohol, 0.5% glyceryl monostearate, 12% PKOEs, and 27% Tween ® 80/Span ® 80 (9/1) with a hydrophilic lipophilic balance of 13.9, and a 59.5% phosphate buffer system at pH 7.4. Formulation F36 was comprised of 0.05% P. urinaria extract, 1% cetyl alcohol, 1% glyceryl monostearate, 14% PKOEs, 28% Tween ® 80/Span ® 80 (9/1) with a hydrophilic lipophilic balance of 13.9, and 56% phosphate buffer system at pH 7.4 with shear thinning and thixotropy. The droplet size of F12 and F36 was 30.74 nm and 35.71 nm, respectively, and their nanosizes were confirmed by transmission electron microscopy images. Thereafter, 51.30% and 51.02% of the loaded extract was released from F12 and F36 through an artificial cellulose membrane, scavenging 29.89% and 30.05% of DPPH radical activity, respectively. Conclusion The P. urinaria extract was successfully incorporated into a PKOEs-based nanoemulsion delivery system. In vitro release of the extract from the formulations showed DPPH radical scavenging activity. These formulations can neutralize reactive oxygen species and counteract oxidative injury induced by ultraviolet radiation and thereby ameliorate skin aging.

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“…The physicochemical properties of nanoemulsions are influenced by both their qualitative and quantitative compositions, and hence, they should be synthesized under strictly controlled conditions. 165 Certain inconsistencies exist in the literature with respect to the concept of nanoemulsions in relation to MEs. Although both systems have similar structural and visual characteristics, they differ in their thermodynamic stability.…”

Section: Mes and Nanoemulsionsmentioning

confidence: 99%

Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

Ramos¹,

Silva²,

Spósito³

et al. 2018

IJN

220

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Since the dawn of civilization, it has been understood that pathogenic microorganisms cause infectious conditions in humans, which at times, may prove fatal. Among the different virulent properties of microorganisms is their ability to form biofilms, which has been directly related to the development of chronic infections with increased disease severity. A problem in the elimination of such complex structures (biofilms) is resistance to the drugs that are currently used in clinical practice, and therefore, it becomes imperative to search for new compounds that have anti-biofilm activity. In this context, nanotechnology provides secure platforms for targeted delivery of drugs to treat numerous microbial infections that are caused by biofilms. Among the many applications of such nanotechnology-based drug delivery systems is their ability to enhance the bioactive potential of therapeutic agents. The present study reports the use of important nanoparticles, such as liposomes, microemulsions, cyclodextrins, solid lipid nanoparticles, polymeric nanoparticles, and metallic nanoparticles, in controlling microbial biofilms by targeted drug delivery. Such utilization of these nanosystems has led to a better understanding of their applications and their role in combating biofilms.

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The effect of oil components on the physicochemical properties and drug delivery of emulsions: Tocol emulsion versus lipid emulsion

Cited by 71 publications

References 32 publications

Development and Characterization of Resveratrol Nanoemulsions Carrying Dual-Imaging Agents

Development and Characterization of Resveratrol Nanoemulsions Carrying Dual-Imaging Agents

Formulation and in vitro release evaluation of newly synthesized palm kernel oil esters-based nanoemulsion delivery system for 30% ethanolic dried extract derived from local Phyllanthus urinaria for skin antiaging

Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

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