The effect of oleuropein on unilateral ureteral obstruction induced-kidney injury in rats: the role of oxidative stress, inflammation and apoptosis

Kaeidi, Ayat; Sahamsizadeh, Ali; Allahtavakoli, Mohammad; Fatemi, Iman; Rahmani, Amir M.; Hakimizadeh, Elham; Hassanshahi, Jalal

doi:10.1007/s11033-019-05237-0

Cited by 26 publications

(21 citation statements)

References 45 publications

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“…This hypothesis is confirmed by the above results, showing a reduction in O 2 •− , H 2 O 2 and nitrotyrosine levels in ACE oil-fed hypertensive mice. Our results are in agreement with previous studies reporting that the secoiridoid oleuropein, a major component of olive polyphenols, increased the levels of SOD and GSH-Px in gentamicin-induced renal toxicity and in cisplatin-induced renal injury models [ 62 , 81 , 82 ], as well as in the kidneys of rats with unilateral ureteral obstruction [ 83 ]. However, due to the complexity of the biochemical pathways involved and the relevance of antioxidant enzymes in the retina, their implication in the eye is currently unpredictable [ 84 ], and different antioxidant profiles are found depending on the specific retinopathy, as reported in AMD [ 85 ] and DR [ 86 ], among others.…”

Section: Discussionsupporting

confidence: 93%

Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension

et al. 2020

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Oxidative stress plays an important role in the pathogenesis of ocular diseases, including hypertensive eye diseases. The beneficial effects of olive oil on cardiovascular diseases might rely on minor constituents. Currently, very little is known about the chemical composition and/or therapeutic effects of the cultivated olive tree’s counterpart, wild olive (also known in Spain as acebuche—ACE). Here, we aimed to analyze the antioxidant and retinoprotective effects of ACE oil on the eye of hypertensive mice made hypertensive via administration of NG-nitro-L-arginine-methyl-ester (L-NAME), which were subjected to a dietary supplementation with either ACE oil or extra virgin olive oil (EVOO) for comparison purposes. Deep analyses of major and minor compounds present in both oils was accompanied by blood pressure monitoring, morphometric analyses, as well as different determinations of oxidative stress-related parameters in retinal layers. Aside from its antihypertensive effect, an ACE oil-enriched diet reduced NADPH (nicotinamide adenine dinucleotide phosphate) oxidase activity/gene/protein expression (with a major implication of NADPH oxidase (NOX)2 isoform) in the retinas of hypertensive mice. Supplementation with ACE oil in hypertensive animals also improved alterations in nitric oxide bioavailability and in antioxidant enzyme profile. Interestingly, our findings show that the use of ACE oil resulted in better outcomes, compared with reference EVOO, against hypertension-related oxidative retinal damage.

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Section: Discussionsupporting

confidence: 93%

Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension

et al. 2020

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“…In particular, it was shown that dietary OL and OLE treatments were associated with reductions in the production of superoxide anion radical in human monocytes from healthy donors [35]. Similarly, OL administration significantly increased the SOD and glutathione peroxidase (GPx) activity levels in the obstructed kidneys from rats with unilateral ureteral obstruction induced-kidney injury [36]. These results are in accordance with other reports showing that OL was able to increase the amount of enzymes such as GPx and SOD in gentamicin-induced renal toxicity and cisplatin-induced renal injury models [37,38].…”

Section: Functional and Physiological Chemistry Of The Main Secoiridomentioning

confidence: 99%

Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases

et al. 2020

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Iridoids, which have beneficial health properties, include a wide group of cyclopentane [c] pyran monoterpenoids present in plants and insects. The cleavage of the cyclopentane ring leads to secoiridoids. Mainly, secoiridoids have shown a variety of pharmacological effects including anti-diabetic, antioxidant, anti-inflammatory, immunosuppressive, neuroprotective, anti-cancer, and anti-obesity, which increase the interest of studying these types of bioactive compounds in depth. Secoiridoids are thoroughly distributed in several families of plants such as Oleaceae, Valerianaceae, Gentianaceae and Pedialaceae, among others. Specifically, Olea europaea L. (Oleaceae) is rich in oleuropein (OL), dimethyl-OL, and ligstroside secoiridoids, and their hydrolysis derivatives are mostly OL-aglycone, oleocanthal (OLE), oleacein (OLA), elenolate, oleoside-11-methyl ester, elenoic acid, hydroxytyrosol (HTy), and tyrosol (Ty). These compounds have proved their efficacy in the management of diabetes, cardiovascular and neurodegenerative disorders, cancer, and viral and microbial infections. Particularly, the antioxidant, anti-inflammatory, and immunomodulatory properties of secoiridoids from the olive tree (Olea europaea L. (Oleaceae)) have been suggested as a potential application in a large number of inflammatory and reactive oxygen species (ROS)-mediated diseases. Thus, the purpose of this review is to summarize recent advances in the protective role of secoiridoids derived from the olive tree (preclinical studies and clinical trials) in diseases with an important pathogenic contribution of oxidative and peroxidative stress and damage, focusing on their plausible mechanisms of the action involved.

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“…The major compound of olive leaves is oleuropein, which modulates in ammatory parameters and reduces oxidative stress [19]. It has been shown to have antioxidant [20], anti-in ammatory [21], antihypertensive [22], cardioprotective [23], antidiabetic [24], anticancer [25], and hypolipidemic[26] effects.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Rats

et al. 2021

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Acute lung injury (ALI) is one of the most common causes of death in diseases with septic shock.Oleuropein, one of the important components of olive leaf, has antioxidant and anti-in ammatory effects. The objective of this study was to investigate the effects of oleuropein on lipopolysaccharide (LPS)induced ALI in rats. Oleuropein was administered to rats at a dose of 200 mg/kg for 20 days and LPS was given through intratracheal administration to induce ALI. The study was terminated after 12 hours. The results showed that in the group treated with oleuropein; in ammatory cytokines and oxidative stress decreased in serum, bronchoalveolar lavage uid (BALF), and lung tissue, and there were signi cant improvements in the picture of acute interstitial pneumonia (AIP) caused by LPS in histopathological examination.Based on the ndings of the present study, oleuropein showed protective effects against LPS-induced ALI.

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The effect of oleuropein on unilateral ureteral obstruction induced-kidney injury in rats: the role of oxidative stress, inflammation and apoptosis

Cited by 26 publications

References 45 publications

Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension

Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension

Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases

Ameliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Rats

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