The effect of olive leaf extract on digestive enzyme inhibition and insulin production in streptozotocin-induced diabetic rats

Temiz, Mehmet Ali; Temur, Atilla

doi:10.33988/auvfd.423491

Cited by 8 publications

(5 citation statements)

References 24 publications

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“…e leaf extract is more potent than oleuropein in preventing the cytotoxic effects and only leaf extract preserves GPx [234] In STZ-diabetic male rats, the extract ameliorates diabetic alterations [235] In STZ-diabetic male rats, it decreases glycaemia and HbA1c and increases insulin. It also inhibits α-amylase and α-glucosidase [236] In acellular model, it inhibits DPPH radical generation. In STZ-diabetic male rats, the extract increases CAT activity, GSH and lowers lipid peroxidation, Chol, TG, histological pancreas, and hepatic damage [237] In male alloxan-diabetic rats, it shows a hypoglycemic effect and reduces the damage of islets of langerhans [238] In cultured neonatal rat cardiomyocytes of both sexes, it decreases maximum I (Ca,L) in a reversible manner [239] Male rats fed with a high-fat diet develop signs of metabolic syndrome.…”

Section: Effects Of Evoo Voo Oo Leaf Extracts and Mpcs Onmentioning

confidence: 99%

Is Extra Virgin Olive Oil an Ally for Women’s and Men’s Cardiovascular Health?

Franconi

Campesi

Romani

2020

Cardiovascular Therapeutics

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Noncommunicable diseases are long-lasting and slowly progressive and are the leading causes of death and disability. They include cardiovascular diseases (CVD) and diabetes mellitus (DM) that are rising worldwide, with CVD being the leading cause of death in developed countries. Thus, there is a need to find new preventive and therapeutic approaches. Polyphenols seem to have cardioprotective properties; among them, polyphenols and/or minor polar compounds of extra virgin olive oil (EVOO) are attracting special interest. In consideration of numerous sex differences present in CVD and DM, in this narrative review, we applied “gender glasses.” Globally, it emerges that olive oil and its derivatives exert some anti-inflammatory and antioxidant effects, modulate glucose metabolism, and ameliorate endothelial dysfunction. However, as in prescription drugs, also in this case there is an important gender bias because the majority of the preclinical studies are performed on male animals, and the sex of donors of cells is not often known; thus a sex/gender bias characterizes preclinical research. There are numerous clinical studies that seem to suggest the benefits of EVOO and its derivatives in CVD; however, these studies have numerous limitations, presenting also a considerable heterogeneity across the interventions. Among limitations, one of the most relevant in the era of personalized medicine, is the non-attention versus women that are few and, also when they are enrolled, sex analysis is lacking. Therefore, in our opinion, it is time to perform more long, extensive and lessheterogeneous trials enrolling both women and men.

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Section: Effects Of Evoo Voo Oo Leaf Extracts and Mpcs Onmentioning

confidence: 99%

Is Extra Virgin Olive Oil an Ally for Women’s and Men’s Cardiovascular Health?

Franconi

Campesi

Romani

2020

Cardiovascular Therapeutics

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“…Phytochemicals in herbs can exert antidiabetic effects through various mechanisms. These mechanisms may be through inhibition of digestive enzymes and/or by acting like insulin-mimetic to reduce postprandial blood glucose (Temiz & Temur, 2019). Besides they might have antidiabetic effects such as reducing glucose absorption in the small intestine, stimulation of insulin secretion from islets, improving insulin sensibility, and increasing the uptake and bioavailability of glucose to the cells (Temiz and Temur, 2019;Temiz, 2021;Yang et al, 2015;Zhang et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

Investigation of Phenolic Composition, Antioxidant Capacity, and Antidiabetic Effect of Ornithogalum lanceolatum L.: An in vitro Study

Temiz

2021

International Journal of Secondary Metabolite

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Diabetes Mellitus is a global health problem that leads to macro-and microvascular diseases associated with hyperglycemia. Phytotherapy is one of the alternative ways to cope with this type of disease. The genus Ornithogalum is consumed as a wild edible plant and traditionally used for ailments. This study aims to investigate the phenolic composition using High-Performance Liquid Chromatography as well as antioxidant and antidiabetic effects using spectrophotometric method of Ornithogalum lanceolatum L. aerial parts and bulb. In order to determine the antioxidant capacity total phenolic content, total flavonoid content and DPPH and ABTS free radical scavenging activities were analyzed in O. lanceolatum. Moreover, in vitro inhibitory effects of the O. lanceolatum aerial parts and bulb on digestive enzymes were determined by evaluating the α-amylase and α-glucosidase activities. Protocatechuic acid was found to be the main compound in both plant parts. However, the amounts of the total phenolic acids and flavonoids were found higher in the aerial parts than those in bulb as well. Furthermore, O. lanceolatum aerial parts exhibited more radical scavenging activity than bulb. The α-amylase and α-glucosidase IC50 inhibition activities of aerial parts were found more efficient than those for bulb. It can be concluded that O. lanceolatum can enhance the antioxidant status and also can prevent nutraceutically postprandial hyperglycemia by inhibiting α-amylase and α-glucosidase enzymes. These findings reveal the importance of traditional remedies in the ethnopharmacological use of herbs.

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“…Previous studies have shown that several herbs and species, including components of the food supplement (Diapin ® ) used in the present study, exhibit antidiabetic properties. Temiz & Temur (2019) demonstrated that the extract of olive leaves significantly inhibited intestinal α-amylase and α-glucosidase of streptozotocin-induced diabetic rats. In addition, the levels of insulin increased, while those of blood glucose and glycated haemoglobin decreased.…”

Section: Discussionmentioning

confidence: 97%

Diapin®: A food supplement with diverse therapeutic potentials

Magaji¹,

Boyacı²,

Bülbül³

et al. 2022

ijp

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Background and Aims: For many centuries herbs and spices have traditionally been used to treat or manage a variety of diseases. The formulation of food supplements containing single or multiple herbs or spices is now popular. These formulations provide biochemical, pharmacological and medicinal benefits due to their diverse phytochemical constituents. Methods: In the present study, Diapin® -a food supplement containing Olea europaea L. leaves extract, Cinnamomum cassia (L.) J. Presl stem extract, Nigella sativa L. seed oil, Cocos nucifera L. oil and vitamin D3 -dissolved in absolute ethanol was evaluated for α-amylase, α-glucosidase, acetylcholinesterase, elastase, neuraminidase, adenosine deaminase and arginase inhibitory activity. Results:The supplement strongly inhibited neuraminidase (IC 50 = 0.272 ± 0.007 mg/mL), while adenosine deaminase, acetylcholinesterase, elastase and arginase were moderately inhibited (with an IC 50 of 4.562 ± 0.052, 5.396 ± 0.563, 5.783 ± 0.058 and 6.800 ± 0.067 mg/mL respectively). The less inhibition activity was on α-amylase and α-glucosidase (IC 50 = 9.593 ± 0.582 and 14.010 ± 2.280 mg/mL respectively). Conclusion:The pharmacological activities of Diapin® can be attributed to its opulent phytochemical composition. The present findings support the folkloric claim of Diapin® supplement having antidiabetic, anticancer, anti-inflammatory, antimicrobial, anti-ageing, and immune bolstering properties, in addition to the mitigation of Alzheimer's disease and the alleviation of neurological dysfunction.

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The effect of olive leaf extract on digestive enzyme inhibition and insulin production in streptozotocin-induced diabetic rats

Cited by 8 publications

References 24 publications

Is Extra Virgin Olive Oil an Ally for Women’s and Men’s Cardiovascular Health?

Is Extra Virgin Olive Oil an Ally for Women’s and Men’s Cardiovascular Health?

Investigation of Phenolic Composition, Antioxidant Capacity, and Antidiabetic Effect of Ornithogalum lanceolatum L.: An in vitro Study

Diapin®: A food supplement with diverse therapeutic potentials

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