The effect of omeprazole on oesophageal pH in dogs during anaesthesia

Panti, Ambra; Bennett, Rachel C.; Corletto, Federico; Brearley, J.C.; Jeffery, Nick D.; Mellanby, Richard J.

doi:10.1111/j.1748-5827.2009.00818.x

Cited by 58 publications

(59 citation statements)

References 32 publications

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“…Gastroesophageal reflux was detected in 13.3% of the anesthetized dogs in the present study, with this incidence being lower than that observed in other studies with percentages varying from 46 to 60% (Wilson et al 2005(Wilson et al , 2006aPanti et al 2009). All these studies have in common the administration of morphine as part of the pre-anesthetic medication; this seems reasonable when one takes into consideration the finding that morphine reduces EGS tone (Hall et al 1975).…”

Section: Discussioncontrasting

confidence: 82%

“…This technique allows to identify reflux episodes not visualized as regurgitation, as well as to determine some anesthetic agents that predispose to reflux (Galatos and Raptopoulos 1995a, b;Raptopoulos and Galatos 1997;Wilson et al 2005Wilson et al , 2006aWilson et al , b, 2007Anagnostou et al 2009;Panti et al 2009). It has also allowed to determine that the incidence of GER episodes varies between 4.8% (Anagnostou et al 2009) and 60% (Wilson et al 2005), being influenced by several factors, such as age, type of surgical procedure (Galatos and Raptopoulos 1995a), duration of pre-operative fasting, and drugs used for pre-anesthetic medication (Galatos and Raptopoulos 1995b), induction (Raptopoulos and Galatos 1997) and maintenance (Hashim et al 1995;Wilson et al 2006a) of anesthesia.…”

Section: Introductionmentioning

confidence: 98%

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Ambulatory esophageal pHmetry in healthy dogs with and without the influence of general anesthesia

et al. 2011

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This research aimed to determine the value of esophageal pH in awake and anesthetized dogs, to evaluate the esophageal pH value in awake dogs, in different body positions, as well as to study the occurrence of gastroesophageal reflux episodes in these positions. Thus, 40 healthy male and female adult dogs with mean body weight of 15.5 ± 4.6 kg were used. Esophageal pHmetry was conducted by inserting a catheter through the oropharynx in 30 dogs (stage 1) anesthetized with acepromazine, propofol and isoflurane, submitted to elective ovariosalpingohysterectomy. In addition, 8-h esophageal pHmetry was carried out transnasally in 10 awake dogs (stage 2), allowed to move and change body positions (lateral and sternal decubitus, and standing position), which were recorded. The mean esophageal pH value was lower (p < 0.01) in the anesthetized dogs (7.3 ± 0.82) than in the awake dogs (8.2 ± 0.3). Only four anesthetized dogs (13.33%) suffered reflux episodes. Reflux was not observed in the awake dogs and no esophageal pH differences were found between the body positions studied. Compared to the alert state, general anesthesia in dogs submitted to the previously mentioned anesthesia protocol causes esophageal pH reduction and predisposes to the occurrence of gastroesophageal reflux episodes. Transnasal pHmetry of 8 h in healthy awake dogs reveals that the esophageal pH value is alkaline and does not vary according to body position. In these animals, decubitus position is not a determining factor for reflux episodes to occur.

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Section: Discussioncontrasting

confidence: 82%

Section: Introductionmentioning

confidence: 98%

Ambulatory esophageal pHmetry in healthy dogs with and without the influence of general anesthesia

et al. 2011

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“…Studies evaluating GER in anesthetized humans and dogs have focused on the use of prokinetics and medications to reduce gastric acidity to prevent reflux (Wilson et al ., 2006b;Panti et al ., 2009;Favarato et al ., 2012). In humans, it is also known that drugs that decrease hydrochloric acid production in the stomach, such as ranitidine and omeprazole increase pH and gastric fluids during surgery and therefore decrease the risk of developing Mendelson's syndrome (Grümberg, 2003;Moro, 2004).…”

Section: Preventing Ger During Anesthesiamentioning

confidence: 99%

Gastroesophageal reflux in anesthetized dogs: a review

Rodríguez-Alarcón

Rivera-Barreno

Díaz

et al. 2015

Rev Colomb Cienc Pecu

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SummaryGastroesophageal reflux can be a catastrophic illness in small animals during anesthesia since its complications can cause serious pathologies, such as esophagitis, esophageal stenosis and aspiration pneumonia. With an incidence from 12 to 78.5% in anesthetized dogs, gastroesophageal reflux is normally silent during anesthesia and will be notices only if regurgitation occurs and stomach acid is present in the nasal or oral cavities. In humans, gastroesophageal reflux disease (GERD) is a well-defined pathology where the lower esophageal sphincter has a sustained weakness. However, in dogs, gastroesophageal reflux disease as such is not well established, if at all; it has only been described as gastroesophagic reflux, occurring principally in anesthetized animals. There are several factors influencing the presentation of reflux in anesthetized dogs, which may be inherent to the patient (e.g. age, sex, breed, weight, or body condition), medications used prior to and during anesthesia, type of surgery or position of the animal during surgery. The objective of this review is to discuss a series of conditions that could predispose dogs to gastroesophageal reflux during anesthesia and to assist in the prevention and diagnosis of this condition.

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“…Na medicina veterinária, inúmeras pesquisas utilizaram a pHmetria esofágica com a finalidade de avaliar a incidência de episódios de RGE durante procedimentos anestésicos. Essa técnica tornou possível o reconhecimento daqueles animais que apresentavam refluxo não identificado visualmente como regurgitação, bem como possibilitou identificar alguns agentes anestésicos que predispõem ao quadro (GALATOS & RAPTOPOULOS, 1995a,b;RAPTOPOULOS & GALATOS, 1997;WILSON et al, 2005, 2006a,b, 2007, ANAGNOSTOU et al, 2009PANTI et al, 2009).…”

Section: Métodos De Diagnóstico Dos Episódios De Refluxo Gastroesofágunclassified

Refluxo gastroesofágico em cães anestesiados: fisiopatologia, clínica, diagnóstico e terapêutica

Favarato¹,

Souza²,

Costa³

2010

Cienc. Rural

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The effect of omeprazole on oesophageal pH in dogs during anaesthesia

Abstract: This study suggests that the preoperative administration of omeprazole is effective in reducing the incidence of gastro-oesophageal reflux during anaesthesia in dogs.

Cited by 58 publications

References 32 publications

Ambulatory esophageal pHmetry in healthy dogs with and without the influence of general anesthesia

Ambulatory esophageal pHmetry in healthy dogs with and without the influence of general anesthesia

Gastroesophageal reflux in anesthetized dogs: a review

Refluxo gastroesofágico em cães anestesiados: fisiopatologia, clínica, diagnóstico e terapêutica

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