The Effect of Onion Peel Extract on Inflammatory Mediators in Korean Overweight and Obese Women

Kim, Kyung-Ah; Yim, Jung‐Eun

doi:10.7762/cnr.2016.5.4.261

Cited by 26 publications

(24 citation statements)

References 42 publications

(48 reference statements)

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“…In a study by Kim and Yim [70], OPE administration (100 mg/d, 50 mg bis a die) for 12 weeks significantly reduces waist and hip circumference, and the effects are ascribed to the reduced oxidative stress in obese women. However, the follow-up study showed no influence on the inflammatory mediators among the obese women [95].…”

Section: Anti-obesity and Hypolipidemic Effectsmentioning

confidence: 82%

Allium Flavonols: Health Benefits, Molecular Targets, and Bioavailability

2020

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Allium species are revered worldwide as vegetables, condiments, and spices as well as the therapeutic agents in traditional medicine. The bioactive compounds in alliums mainly include organosulfur compounds, polyphenols, dietary fibers, and saponins. Flavonoids, particularly flavonols from alliums, have been demonstrated to have the antioxidant, anticancer, hypolipidemic, anti-diabetic, cardioprotective, neuroprotective, and antimicrobial activities. However, flavonols are mostly characterized from onions and have not been comprehensively reviewed across different species. This article therefore focuses on flavonol profiles from different Allium species, their health effects, underlying molecular mechanisms, and bioavailability. Intriguingly, the functional health effects of flavonols were mainly ascribed to their antioxidant and anti-inflammatory activities involving a cascade of multiple signaling pathways. Although the Allium-derived flavonols offer tremendous potential in preventing chronic disease risks, in-depth studies are needed to translate their clinical application.

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Section: Anti-obesity and Hypolipidemic Effectsmentioning

confidence: 82%

Allium Flavonols: Health Benefits, Molecular Targets, and Bioavailability

2020

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“…When given acutely, quercetin reduced plasma endothelin-1 (Loke et al 2008), reduced blood pressure in overweight volunteers but only of a certain genotype (Egert et al 2010a), but did not reduce urinary F2-isoprostanes (Loke et al 2008), nor blood pressure in normal weight volunteers (Egert et al 2010b). When given in the form of onion skin extract, quercetin did not affect systemic inflammation in overweight women (Kim & Yim 2016), post-prandial blood pressure, endothelial function, serum leptin nor adiponectin in overweight adults (Brull et al 2016(Brull et al , 2017. These various studies suggest that quercetin exerts some effects in humans but the exact effect is highly dependent on the individual's metabolic and genetic status, and on the form given.…”

Section: Human Intervention Studies On the Flavonol Quercetinmentioning

confidence: 90%

“…). When given in the form of onion skin extract, quercetin did not affect systemic inflammation in overweight women (Kim & Yim ), post‐prandial blood pressure, endothelial function, serum leptin nor adiponectin in overweight adults (Brull et al . , ).…”

Section: Human Intervention Studies On the Flavonol Quercetinmentioning

confidence: 99%

The role of polyphenols in modern nutrition

2017

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Polyphenols are found in plant‐based foods and beverages, notably apples, berries, citrus fruit, plums, broccoli, cocoa, tea and coffee and many others. There is substantial epidemiological evidence that a diet high in polyphenol‐rich fruit, vegetables, cocoa and beverages protects against developing cardiovascular disease and type 2 diabetes. The absorption and metabolism of these compounds have been well described and, for many, the gut microbiota play a critical role in absorption; taking into consideration the parent compound and the metabolites from colon bacteria catabolism, more than 80% of a dose can be absorbed and ultimately excreted in the urine. Common polyphenols in the diet are flavanols (cocoa, tea, apples, broad beans), flavanones (hesperidin in citrus fruit), hydroxycinnamates (coffee, many fruits), flavonols (quercetin in onions, apples and tea) and anthocyanins (berries). Many intervention studies, mechanistic in vitro data and epidemiological studies support a role for polyphenols against the development of chronic diseases. For example, flavanols decrease endothelial dysfunction, lower blood pressure and cholesterol, and modulate energy metabolism. Coffee and tea both reduce the risk of developing type 2 diabetes, through action of their constituent polyphenols. Despite extensive research, the exact mechanisms of action of polyphenols in the human body have not been decisively proven, but there is strong evidence that some targets such as nitric oxide metabolism, carbohydrate digestion and oxidative enzymes are important for health benefits. Consumption of polyphenols as healthy dietary components is consistent with the advice to eat five or more portions of fruit and vegetables per day, but it is currently difficult to recommend what ‘doses’ of specific polyphenols should be consumed to derive maximum benefit.

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“…Previous studies have been mostly carried out on QR (25)(26)(27), an important flavonol in onion. Therefore, we had to compare the results of the present study with QR-based researches.…”

Section: Discussionmentioning

confidence: 99%