The Effect of Optimising Cerebral Tissue Oxygen Saturation on Markers of Neurological Injury during Coronary Artery Bypass Graft Surgery

Harilall, Yakeen; Adam, Jamila K.; Biccard, Bruce M.; Reddi, Anu

doi:10.1016/j.hlc.2013.07.002

Cited by 41 publications

(39 citation statements)

References 10 publications

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“…In two trials the target NIRS value was > 75% of baseline. 235,243 In three trials the target value was > 80%. 242,244,246 In one trial the target NIRS value was greater than an absolute NIRS value of 60% or > 20% compared with the mean value during pulmonary artery catheter insertion.…”

Section: Interventionmentioning

confidence: 92%

“…Random sequence generation was adequate in seven trials, 45,154,235,240,241,243,246 and unclear in two trials. 242,245 There was a high risk of bias for random sequence generation in one trial.…”

Section: Risk Of Bias In Included Studiesmentioning

confidence: 97%

“…241 Seven trials used a version of the Murkin algorithm to optimise NIRS values. 154,235,240,242,243,245,246 Three studies used non-Murkin algorithms.…”

Section: Interventionmentioning

confidence: 99%

“…In seven trials NIRS values were measured in the control group, although this was hidden from the clinical personnel. 154,235,[241][242][243]245,246 No trial considered an alternative patient-specific goal-directed algorithm.…”

Section: Controlmentioning

confidence: 99%

“…There was evidence of blinding of participants and clinical staff caring for participants postoperatively in four trials, 45,154,242,244 with unclear evidence in six trials. 235,240,241,243,245,246 Three trials reported the frequency of protocol compliance. 45,154,241 In seven trials non-compliance was not monitored or not specified.…”

Section: Blindingmentioning

confidence: 99%

See 4 more Smart Citations

Diagnostic and therapeutic medical devices for safer blood management in cardiac surgery: systematic reviews, observational studies and randomised controlled trials

Murphy

Mumford

Rogers

et al. 2017

Programme Grants Appl Res

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This report should be referenced as follows:Murphy GJ, Mumford AD, Rogers CA, Wordsworth S, Stokes EA, Verheyden V, et al. Diagnostic and therapeutic medical devices for safer blood management in cardiac surgery: systematic reviews, observational studies and randomised controlled trials. Programme Grants Appl Res 2017;5(17). Programme Grants for Applied ResearchISSN 2050-4322 (Print) ISSN 2050-4330 (Online) This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: journals.library@nihr.ac.ukThe full PGfAR archive is freely available to view online at www.journalslibrary.nihr.ac.uk/pgfar. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Programme Grants for Applied Research journalReports are published in Programme Grants for Applied Research (PGfAR) if (1) they have resulted from work for the PGfAR programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors. Programme Grants for Applied Research programmeThe Programme Grants for Applied Research (PGfAR) programme, part of the National Institute for Health Research (NIHR), was set up in 2006 to produce independent research findings that will have practical application for the benefit of patients and the NHS in the relatively near future. The Programme is managed by the NIHR Central Commissioning Facility (CCF) with strategic input from the Programme Director.The programme is a national response mode funding scheme that aims to provide evidence to improve health outcomes in England through promotion of health, prevention of ill health, and optimal disease management (including safety and quality), with particular emphasis on conditions causing significant disease burden.For more information about the PGfAR programme please visit the website: http://www.nihr.ac.uk/funding/programme-grants-forapplied-research.htm This reportThe research reported in this issue of the journal was funded by PGfAR as project number RP-PG-0407-10384. The contractual start date was in July 2008. The final report began editorial review in July 2016 and was accepted for publication in April 2017. As the funder, the PGfAR programme agreed the research questions and study designs in advance with the investigators. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The PGfAR editors and production house have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the final report document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not ...

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Section: Interventionmentioning

confidence: 92%

Section: Risk Of Bias In Included Studiesmentioning

confidence: 97%

“…241 Seven trials used a version of the Murkin algorithm to optimise NIRS values. 154,235,240,242,243,245,246 Three studies used non-Murkin algorithms.…”

Section: Interventionmentioning

confidence: 99%

Section: Controlmentioning

confidence: 99%

Section: Blindingmentioning

confidence: 99%

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Diagnostic and therapeutic medical devices for safer blood management in cardiac surgery: systematic reviews, observational studies and randomised controlled trials

Murphy

Mumford

Rogers

et al. 2017

Programme Grants Appl Res

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Cerebral near-infrared spectroscopy (NIRS) for perioperative monitoring of brain oxygenation in children and adults

Zhang

et al. 2018

Cochrane Database of Systematic Reviews

108

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The effects of perioperative active cerebral NIRS monitoring of brain oxygenation in adults for reducing the occurrence of short-term, mild POCD are uncertain due to the low quality of the evidence. There is uncertainty as to whether active cerebral NIRS monitoring has an important effect on postoperative stroke, delirium or death because of the low number of events and wide confidence intervals. The conclusions of this review may change when the eight ongoing studies are published and the 12 studies awaiting assessment are classified. More RCTs performed in the paediatric population and high-risk patients undergoing non-cardiac surgery (e.g. neurosurgery, carotid endarterectomy and other surgery) are needed.

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Lung Transplantation

Roscoe¹,

Klinger²

2019

Principles and Practice of Anesthesia for Thoracic Surgery

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The Effect of Optimising Cerebral Tissue Oxygen Saturation on Markers of Neurological Injury during Coronary Artery Bypass Graft Surgery

Cited by 41 publications

References 10 publications

Diagnostic and therapeutic medical devices for safer blood management in cardiac surgery: systematic reviews, observational studies and randomised controlled trials

Diagnostic and therapeutic medical devices for safer blood management in cardiac surgery: systematic reviews, observational studies and randomised controlled trials

Cerebral near-infrared spectroscopy (NIRS) for perioperative monitoring of brain oxygenation in children and adults

Lung Transplantation

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