The effect of oral metformin on insulin sensitivity in insulin-resistant ponies

Tinworth, Kellie D.; Boston, Ray; Harris, Patricia A.; Sillence, Martin N.; Raidal, Sharanne; Noble, Glenys

doi:10.1016/j.tvjl.2011.01.015

Cited by 64 publications

(41 citation statements)

References 41 publications

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“…Previous studies on metformin have yielded mixed results [3][4][5][6] and John-Pierre Lavoie (Universit e de Montr eal, Canada) presented a blinded trial in which metformin decreased bodyweight and the owner's assessment of overall condition, but did not significantly alter glucose and insulin values. David Rendle (Charles Sturt University, Australia) reported pharmacokinetics and pharmacodynamics of oral pergolide suggesting a fairly rapid onset of action.…”

Section: Pharmacologymentioning

confidence: 99%

Science‐in‐brief: Workshop report The Dorothy Havemeyer International Equine Endocrinology Summit

Durham¹,

Bailey

Frank

et al. 2017

Equine Veterinary Journal

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Section: Pharmacologymentioning

confidence: 99%

Science‐in‐brief: Workshop report The Dorothy Havemeyer International Equine Endocrinology Summit

Durham¹,

Bailey

Frank

et al. 2017

Equine Veterinary Journal

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“…Nevertheless, other authors reported inefficiency of this drug and this is why it was not used for this mare (Tinworth et al, 2012).…”

Section: Discussionmentioning

confidence: 94%

Equine metabolic syndrome in Colombian creole horse: case report

Castillo

Jaramillo

Loaiza

et al. 2017

Arq. Bras. Med. Vet. Zootec.

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The equine metabolic syndrome is a condition that can be recognized because of obesity, insulin resistance and laminitis. Genetic factors could play a role in the occurrence of this syndrome. Certain breeds such as ponies (including the South American creole horses) have a lower sensibility to insulin and a higher prevalence of hyperinsulinemia. The environment and management conditions, such as overfeeding and lack of exercise are factors that bring a propensity for obesity. The adipose tissue works as an endocrine organ producing hormones (adipokines or adipocytokines) that affect the horse´s metabolism. The objective of this report is to describe the first case report of a Colombian creole mare with a metabolic syndrome, diagnosed by means of the combined test of glucose-insulin and clinical signs. Early diagnosis of this entity and an adequate treatment are useful for improving the life and the zootechnical conditions of the patient.Keywords: equine, insulin resistance, obesity, laminitis RESUMO A síndrome metabólica equina é uma alteração reconhecida por apresentar obesidade, resistência à insulina e laminite. Fatores genéticos poderiam ser relevantes na ocorrência dessa síndrome, em que certas raças consideradas pôneis (incluídas as raças crioulas de cavalos sul-americanos) têm mais baixa

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“…Strategies for management of overweight/obese animals include: -Promotion of weight loss and improved insulin sensitivity via dietary restriction and, when possible, an increase in physical activity -Avoidance of feeds that may exacerbate insulin resistance and hyperinsulinemia (feeds rich in non-structural carbohydrates such as grains, grain-based commercial feeds, and "lush" or stressed pasture forages) -In some animals, treatment with levothyroxine sodium may be indicated for promotion of weight loss if appropriate dietary restriction and exercise regimens are not effective • Regular monitoring and adjustments in feeding and physical activity are required -individual animals will lose weight at different rates and will require different levels of feed restriction • Once target weight has been achieved, an ongoing program of weight maintenance is needed mean insulin sensitivity (Frank et al 2008). More work is needed to evaluate the true efficacy, optimal dose and dosing regimen for levothyroxine and other medications such as metformin (Tinworth et al 2011). The recommended dosage for weight loss in mature horses is 48 mg/day (about 4 teaspoons, administered in feed) for 3 to 6 months depending on clinical response.…”

Section: Key Pointsmentioning

confidence: 99%

Obesity

Geor¹,

Harris²

2013

Equine Applied and Clinical Nutrition

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Obesity is an emergent problem in domestic horse and pony populations that has health and welfare implications. Equine obesity, in particular, has been associated with insulin resistance and hyperinsulinemia, which are risk factors for laminitis, particularly the pasture-associated form of this condition. Recognition of these adverse consequences of obesity has prompted research on the epidemiology and pathophysiology of obesity in equids as well as strategies for weight loss and other aspects of management that may mitigate risk of obesity-associated health problems. This chapter reviews current knowledge of the prevalence, causes and consequences of obesity in horses and ponies. It also provides recommendations for dietary and exercise management of obesity based on current knowledge and understanding.

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The effect of oral metformin on insulin sensitivity in insulin-resistant ponies

Cited by 64 publications

References 41 publications

Science‐in‐brief: Workshop report The Dorothy Havemeyer International Equine Endocrinology Summit

Science‐in‐brief: Workshop report The Dorothy Havemeyer International Equine Endocrinology Summit

Equine metabolic syndrome in Colombian creole horse: case report

Obesity

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