The effect of oral versus vaginal misoprostol on cervical dilatation in first-trimester abortion: a double-blind, randomized study

İnal, Murat; Ertopcu, Kenan; Arıcı, Akgül; Özelmas, İsa

doi:10.1080/ejc.8.4.197.202

Cited by 8 publications

(3 citation statements)

References 12 publications

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“…Although a variety of medical abortion methods have been introduced during the past decade [12][13][14][15] , surgical methods have a considerable popularity. A data analysis of five randomized studies of any surgical abortion method compared with any medical abortion method in the first trimester has suggested that medical methods seem to be less effective and more painful compared to surgical first-trimester abortion 16 .…”

Section: Discussionmentioning

confidence: 99%

The predictors of retained products of conception following first-trimester pregnancy termination with manual vacuum aspiration

İnal

Yıldırım

Ertopcu

et al. 2006

The European Journal of Contraception & Reproductive Health

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Section: Discussionmentioning

confidence: 99%

The predictors of retained products of conception following first-trimester pregnancy termination with manual vacuum aspiration

İnal

Yıldırım

Ertopcu

et al. 2006

The European Journal of Contraception & Reproductive Health

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“…In addition, vaginal administration was found to be more effective than oral administration later in the first trimester and in multiparous women [102,148]. However, other studies have shown no difference between vaginal and oral administration [90,92,103,149]. Such studies have shown that 400 mcg of oral misoprostol produced equivalent dilatation at 3 h to 400-mcg vaginal dosing, all with similar side effects.…”

Section: Comparisonsmentioning

confidence: 97%

Cervical dilation before first-trimester surgical abortion (< 14 weeks' gestation)

Allen

Goldberg

2016

Contraception

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First-trimester surgical abortion is a common, safe procedure with a major complication rate of less than 1%. Cervical dilation before suction abortion is usually accomplished using tapered mechanical dilators. Risk factors for major complications in the first trimester include increasing gestational age and provider inexperience. Cervical priming before first-trimester surgical abortion has been studied using osmotic dilators and pharmacologic agents, most commonly misoprostol. Extensive data demonstrate that a variety of agents are safe and effective at causing preoperative cervical softening and dilation; however, given the small absolute risk of complications, the benefit of routine use of misoprostol or osmotic dilators in first-trimester surgical abortion is unclear. Although cervical priming results in reduced abortion time and improved provider ease, it requires a delay of at least 1 to 3 h and may confer side effects. The Society of Family Planning does not recommend routine cervical priming for first-trimester suction abortion but recommends limiting consideration of cervical priming for women at increased risk of complications from cervical dilation, including those late in the first trimester, adolescents and women in whom cervical dilation is expected to be challenging.

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“…The degree to which anything is soluble in water. In reality, there is a scarcity of data on the human vaginal permeability of drugs with various physicochemical properties; far further research is required on the effects of physicochemical drug parameters on vaginal absorption 38 .…”

Section: Physicochemical Properties O Drugsmentioning

confidence: 99%

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2022

IJPSR

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HIV is a pandemic disease that is rapidly spreading across the world. The current review's objective is to present how comprehensive various advanced anti-HIV drug delivery systems are. The use of a new drug delivery system helps in overcoming the challenges of dosage form growth, such as drug instability, insolubility, and restricted entrapment. Several delivery routes for ARV therapy have been identified, including trans dermal, mucosal (vaginal, rectal, buccal, etc.) and lymphatic delivery, utilizing novel systems such as nanoparticles, vesicular systems (liposomes, niosomes, ethosomes, emulsomes), micellar assemblies and so on. This review examines the potential of novel drug delivery systems for the prevention, treatment of retroviral infections, approaches and applications of novel drug delivery systems for Anti-HIV agents. INTRODUCTION:The Acquired Immune Deficiency Syndrome (AIDS) and associated infections caused by the human immunodeficiency virus (HIV) have been described as one of the dreadful diseases that pose troubling challenges to community health around the world especially in sub-Saharan Africa 1 . According to global estimates, there are more than 33.2 million people living with this infection. According to predictions from Indian health organizations, India will have about 6-7 million HIV-positive patients. 2.5 million people were newly infected in 2007, 2 .1 million died of AIDS, and 2.5 million people in.

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The effect of oral versus vaginal misoprostol on cervical dilatation in first-trimester abortion: a double-blind, randomized study

Abstract: Different methods of misoprostol administration may not be equivalent in terms of efficacy and side-effects. Therefore, we decided to extend the study to include more patients so as to achieve statistically significant results.

Cited by 8 publications

References 12 publications

The predictors of retained products of conception following first-trimester pregnancy termination with manual vacuum aspiration

The predictors of retained products of conception following first-trimester pregnancy termination with manual vacuum aspiration

Cervical dilation before first-trimester surgical abortion (< 14 weeks' gestation)

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