The effect of organic acids on the control of porcine post-weaning diarrhoea

Tsiloyiannis, V. K.; Kyriakis, S. C.; Vlemmas, J.; Sarris, K.

doi:10.1053/rvsc.2001.0476

Cited by 125 publications

(117 citation statements)

References 18 publications

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“…No período de 36 a 49 dias, o escore fecal dos animais que receberam 0,63% de ácidos orgânicos foi menor que o daqueles que receberam 0,66% e a dieta basal. Esse resultado corrobora os obtidos por Tsiloyiannis et al (2001b), que, utilizando 1,6% de ácido láctico na dieta de leitões no período de 28 dias após o desmame, também observaram menor valor de escore fecal nos animais que receberam ácido na ração aos do tratamento controle. No entanto, os resultados deste estudo diferiram dos verificados por Silva (2004), que não constatou variação no escore fecal em leitões alimentados com acidificantes em relação ao controle.…”

Section: Resultsunclassified

“…Entre as bactérias encontradas, destacou-se a E. coli β -hemólise, isolada das fezes de todos as proporções, o que coincidiu com o histórico da granja de doença do edema, diagnosticada por meio de sinais clínicos típicos e necropsia dos leitões. Silva (2004), trabalhando com ácido láctico e outros ácidos orgânicos, também observou a presença de E. coli, ao contrário de Tsiloyiannis et al (2001b), que verificaram redução no número de E. coli β-hemolítica positiva nas fezes dos animais que receberam ácidos orgânicos no período de 28 dias após o desmame. A E. coli K88 + ß-hemolítica pode diminuir a taxa de crescimento dos animais e, possivelmente, aumentar a mortalidade em decorrência da doença do edema e da diarréia pós-desmame (Pluske et al, 1997;Tsiloyiannis et al, 2001a).…”

Section: Resultsunclassified

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Avaliação de ácidos orgânicos em dietas para leitões de 21 a 49 dias de idade

et al. 2006

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RESUMO -Objetivou-se estudar os efeitos da proporção crescente de ácidos orgânicos na dieta sobre o desempenho e a incidência de diarréia em leitões no período de 21 a 49 dias de idade. Os tratamentos foram constituídos de uma dieta basal e três dietas suplementadas com 0,78; 0,84; e 0,90% (21 a Effects of feeding organic acids for piglets from 21 to 49 days oldABSTRACT -The effects of feeding increasing dietary organic acids on performance and diahrrea incidencefor piglets from 21 to 49 days old were evaluated. The treatments were constituted of a basal diet and three groups supplemented with 0.78, 0.84 and 0.90% of organic acids in the 21 to 35 days period and 0.59, 0.63 and 0.66% in the 36 to 49 days period, basedoin lactic acid. Average daily feed intake (ADFI), average daily weight gain (ADWG), feed:gain ratio (F/G) and diarrhea scores were evaluated. The ADFI and the ADWG did not differ among the organic acids proportions in the evaluated periods. The FCR of piglets fed diet with 0.84% of organic acids was better than those fed basal and 0.90% diets, in the 21 to 35 days period.The piglets fed diet with 0.84% of organic acids showed lower diarrhea score than those fed 0.9 %. Blood samples were collected to dose lactic acid concentration in plasma of piglets at 35 days old. The plasma lactic acid concentration of the animals fed diet with 0.90% of acid increased 60.61% in relation to the basal diet. Bacterias were isolated from animals feces to microorganisms identification. The 0.84 and 0.63% organic acids proportion, in the period form 21 to 35 days and from 36 to 49 days old, respectively, were more efficient considering that the E. coli a-hemolytic and Streptococcus sp bacterias was not isolated. The 0.84% organic acids level in the piglet diets provide better F/G in the period from 21 to 35 days old and better diarrhea score and E. coli a-hemolytic and Streptococcus sp control supplementing 0.84% of acids in the period from 21 to 35 days old and 0.63% from 36 to 49 days.

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Section: Resultsunclassified

Avaliação de ácidos orgânicos em dietas para leitões de 21 a 49 dias de idade

et al. 2006

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“…Some authors showed that during an outbreak of post-weaning diarrhoea, various organic acids were able to reduce the incidence and severity of diarrhoea and exclude the presence of ETEC K88 in the intestine at the end of the experiment [80]. On the contrary, other authors did not observe any positive effect of feeding organic acids on diarrhoea score in ETEC K88 challenged pigs [65].…”

Section: Protection From Intestinal Damagementioning

confidence: 99%

Alternatives to in-feed antibiotics in pigs: Evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa. A comparison of in vitro and in vivo results

et al. 2005

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-Weaned pigs are susceptible to frequent infectious diseases. Antibiotics have been used over decades to reduce pathogen infections, but many microorganisms are becoming resistant to antibiotics. Thus, there is an urgent need to find alternatives to in-feed antibiotics. Up to now, various compounds have been used as alternatives, giving promising but sometimes contrasting results. In recent years, the in vitro models of cell culture have been proposed for the screening of various compounds and understanding their mechanisms of action. The intestine is a complex system with a continuous cross-talk among epithelial cells, the local immune system and microflora. Alternatives to in-feed antibiotics may interact with any of these constituents. This review presents data on the protective effects of probiotics, zinc salts and organic acids, used as alternatives to in-feed antibiotics, against pathogen induced damage and inflammatory processes in the intestinal cells and the underlying mechanisms, with an attempt to compare in vitro and in vivo results. All the alternatives tested resulted in effective protection against pathogens by a series of interactions with intestinal cells and pathogens, including the inhibition of adhesion and invasion of pathogens, interference in signalling pathways induced by pathogenic bacteria, maintenance of the epithelial cell cytoskeleton and junctional structure and modulation of the host immune response. microorganismes sont devenus résistants à ces substances. Aussi, est-il urgent de trouver des alternatives aux antibiotiques additifs alimentaires. Jusqu'à présent, diverses alternatives ont été envisagées, certaines donnant des résultats prometteurs, d'autres des résultats variables. Au cours des dernières années, les modèles in vitro de cultures cellulaires ont été proposés pour cribler ces substances et élucider leurs mécanismes d'action. L'intestin est un système complexe faisant intervenir des communications permanentes entre les cellules épithéliales, le système immunitaire local et la microflore. Les alternatives aux antibiotiques peuvent interagir avec n'importe lequel de ces composants. Le présent article fait la synthèse des effets protecteurs et des mécanismes d'action des probiotiques, des sels de zinc et des acides organiques, utilisés comme alternatives aux antibiotiques dans les processus inflammatoires et les altérations cellulaires épithéliales in vitro, induites par des agents pathogènes. Elle tente de comparer ces résultats avec les observations in vivo. Toutes les alternatives évaluées ont été efficaces contre les agents pathogènes, via des mécanismes d'interaction cellules épithéliales-agents pathogènes. Ces mécanismes incluaient l'inhibition de l'adhésion et de l'invasion cellulaire par ces pathogènes, la modulation des mécanismes de signalisation intracellulaire induits par les bactéries pathogènes, le maintien de la structure du cytosquelette et des jonctions serrées des cellules épithéliales, et enfin la modulation des réponses immunitaires de la cellu...

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“…Os resultados de pesquisas com fitase são positivos, levando os nutricionistas a reduzirem ou eliminarem fontes de cálcio e fósforo inorgânicas nas rações de suínos (MOREIRA et al, 2004). Por sua vez, a adição de ácidos objetiva reduzir o efeito alcalinizante da dieta no estômago, tornando mais efetiva a barreira gástrica que impede/ou dificulta a entrada de microorganismos patogênicos no intestino delgado (TSILOYIANNIS et al, 2001). Tem-se observado que o uso de ácidos orgânicos melhora o desempenho animal e aumenta a digestibilidade ileal de aminoácidos e minerais e o aproveitamento da energia (PARTANEN & MROZ, 1999).…”

Section: Introductionunclassified