The effect of organic acids on the control of post-weaning oedema disease of piglets

Tsiloyiannis, V. K.; Kyriakis, S. C.; Vlemmas, J.; Sarris, K.

doi:10.1053/rvsc.2001.0475

Cited by 25 publications

(17 citation statements)

References 11 publications

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“…Silva (2004), trabalhando com ácido láctico e outros ácidos orgânicos, também observou a presença de E. coli, ao contrário de Tsiloyiannis et al (2001b), que verificaram redução no número de E. coli β-hemolítica positiva nas fezes dos animais que receberam ácidos orgânicos no período de 28 dias após o desmame. A E. coli K88 + ß-hemolítica pode diminuir a taxa de crescimento dos animais e, possivelmente, aumentar a mortalidade em decorrência da doença do edema e da diarréia pós-desmame (Pluske et al, 1997;Tsiloyiannis et al, 2001a).…”

Section: Resultsunclassified

“…A resposta dos animais pode ser melhorada com a suplementação com ácidos orgânicos (Jensen, 1998), que vêm sendo apontados como estratégia nutricional eficiente (Partanen & Mroz, 1999;Tsiloyiannis et al, 2001a). A suplementação de dietas com ácidos orgânicos, ou seus sais, tem reduzido a freqüência de diarréia e melhorado o desempenho de leitões (Knarreborg et al, 2002), têm prevenido a doença do edema pós-desmame (Thomlinson & Lawrence, 1981) e controlado o desenvolvimento da E. coli (Presser et al, 1997;Tsiloyiannis et al, 2001a), O ácido láctico é de cadeia curta e, por ser fraco, pode estar entre os ácidos mais efetivos disponíveis no mercado na prevenção de doenças (Partanen & Mroz, 1999).…”

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“…A suplementação de dietas com ácidos orgânicos, ou seus sais, tem reduzido a freqüência de diarréia e melhorado o desempenho de leitões (Knarreborg et al, 2002), têm prevenido a doença do edema pós-desmame (Thomlinson & Lawrence, 1981) e controlado o desenvolvimento da E. coli (Presser et al, 1997;Tsiloyiannis et al, 2001a), O ácido láctico é de cadeia curta e, por ser fraco, pode estar entre os ácidos mais efetivos disponíveis no mercado na prevenção de doenças (Partanen & Mroz, 1999). Os ácidos fracos têm maior atividade antimicrobiana no estô-mago (Canibe et al, 2001;Knarreborg et al, 2002), pois, com sua constante de ionização (pK a ) relativamente maior, apresentam-se em maior concentração na forma não-ionizada.…”

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“…A ação mais efetiva dos ácidos é provavelmente a atividade antimicrobiana, além da modificação da flora intestinal (Burnell et al, 1988), mediante a produção de um meio favorável para bactérias lácticas (Tsiloyiannis et al, 2001a), que promovem benefícios ao organismo do animal e podem, também, causar queda de pH no lúmen intestinal (Giesting & Easter, 1985;Risley et al, 1991;Partanen & Mroz, 1999;Santos et al, 2003).…”

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Avaliação de ácidos orgânicos em dietas para leitões de 21 a 49 dias de idade

et al. 2006

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RESUMO -Objetivou-se estudar os efeitos da proporção crescente de ácidos orgânicos na dieta sobre o desempenho e a incidência de diarréia em leitões no período de 21 a 49 dias de idade. Os tratamentos foram constituídos de uma dieta basal e três dietas suplementadas com 0,78; 0,84; e 0,90% (21 a Effects of feeding organic acids for piglets from 21 to 49 days oldABSTRACT -The effects of feeding increasing dietary organic acids on performance and diahrrea incidencefor piglets from 21 to 49 days old were evaluated. The treatments were constituted of a basal diet and three groups supplemented with 0.78, 0.84 and 0.90% of organic acids in the 21 to 35 days period and 0.59, 0.63 and 0.66% in the 36 to 49 days period, basedoin lactic acid. Average daily feed intake (ADFI), average daily weight gain (ADWG), feed:gain ratio (F/G) and diarrhea scores were evaluated. The ADFI and the ADWG did not differ among the organic acids proportions in the evaluated periods. The FCR of piglets fed diet with 0.84% of organic acids was better than those fed basal and 0.90% diets, in the 21 to 35 days period.The piglets fed diet with 0.84% of organic acids showed lower diarrhea score than those fed 0.9 %. Blood samples were collected to dose lactic acid concentration in plasma of piglets at 35 days old. The plasma lactic acid concentration of the animals fed diet with 0.90% of acid increased 60.61% in relation to the basal diet. Bacterias were isolated from animals feces to microorganisms identification. The 0.84 and 0.63% organic acids proportion, in the period form 21 to 35 days and from 36 to 49 days old, respectively, were more efficient considering that the E. coli a-hemolytic and Streptococcus sp bacterias was not isolated. The 0.84% organic acids level in the piglet diets provide better F/G in the period from 21 to 35 days old and better diarrhea score and E. coli a-hemolytic and Streptococcus sp control supplementing 0.84% of acids in the period from 21 to 35 days old and 0.63% from 36 to 49 days.

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Avaliação de ácidos orgânicos em dietas para leitões de 21 a 49 dias de idade

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“…Activation of MAPKs plays pivotal roles in the expression of various cytokines, including TNF-a, IL-8, IL-6, and IL-12 (27). Furthermore, JNK was shown to be involved in the phosphorylation of IRF3 (Ser 173 ), acting as a positive regulator of IRF3 activation (28).…”

Section: Irak1 and Ikk« Are Involved In Limiting The Activation Of Tamentioning

confidence: 99%

A Novel IRAK1–IKKε Signaling Axis Limits the Activation of TAK1–IKKβ Downstream of TLR3

Bruni

Sebastià

Dunne

et al. 2013

The Journal of Immunology

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IRAK1 is involved in the regulation of type I IFN production downstream of TLR3. Previous work indicated that IRAK1 negatively regulates TRIF-mediated activation of IRF3 and IRF7. We report that IRAK1 limits the activation of the TLR3–NF-κB pathway. Following TLR3 stimulation, IRAK1-deficient macrophages produced increased levels of IL-6 and IFN-β compared with wild type macrophages. Pharmacological inhibition of TAK1 reduced this increase in IFN-β, together with the heightened activation of IRF3 and p65 found in TLR3-ligand stimulated IRAK1-deficient macrophages. Recently, IKKε and TANK-binding kinase 1 (TBK1) were reported to limit activation of the NF-κB pathway downstream of IL-1R, TNFR1, and TLRs. We show that TBK1 has a positive role in the TLR3–NF-κB pathway, because we detected reduced levels of IL-6 and reduced activation of p65 in TBK1-deficient macrophages. In contrast, we show that IKKε limits the activation of the TLR3–NF-κB pathway. Furthermore, we show that IRAK1 is required for the activation of IKKε downstream of TLR3. We report impaired activation of ERK1/2 in IRAK1– and IKKε-deficient macrophages, a novel finding for both kinases. Importantly, this work provides novel mechanistic insight into the regulation of the TLR3-signaling pathway, providing strong evidence that an IRAK1-IKKε–signaling axis acts to limit the production of both type I IFNs and proinflammatory cytokines by regulating TAK1 activity.

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Role of Benzoic, Lactic and Sorbic Acid in In Vitro Swine Cecal Fermentation

Piva

Grilli

2007

Vet Res Commun

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The effect of organic acids on the control of post-weaning oedema disease of piglets

Cited by 25 publications

References 11 publications

Avaliação de ácidos orgânicos em dietas para leitões de 21 a 49 dias de idade

Avaliação de ácidos orgânicos em dietas para leitões de 21 a 49 dias de idade

A Novel IRAK1–IKKε Signaling Axis Limits the Activation of TAK1–IKKβ Downstream of TLR3

Role of Benzoic, Lactic and Sorbic Acid in In Vitro Swine Cecal Fermentation

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