The effect of orthokeratology on axial length elongation in children with myopia: Contralateral comparison study

Na, Miri; Yoo, Aeri

doi:10.1007/s10384-018-0573-x

Cited by 22 publications

(15 citation statements)

References 23 publications

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“…In a 2-year study by Santodomingo-Rubido et al [ 16 ] in patients aged 6-12 years, the axial length of patients wearing OK lenses increased by 0.47 mm, less than 0.69 mm in the group wearing frame glasses. The same conclusion was reached by the teams of Lau et al [ 17 ] and Na et al [ 18 ].…”

Section: Discussionsupporting

confidence: 74%

Novel application of multispectral refraction topography in the observation of myopic control effect by orthokeratology lens in adolescents

Ni¹,

Wang

et al. 2021

WJCC

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BACKGROUND Myopia, as one of the common ocular diseases, often occurs in adolescence. In addition to the harm from itself, it may also lead to serious complications. Thus, prevention and control of myopia are attracting more and more attention. Previous research revealed that single-focal glasses and orthokeratology lenses (OK lenses) played an important part in slowing down myopia and preventing high myopia. AIM To compare the clinical effects of OK lenses and frame glasses against the increase of diopter in adolescent myopia and further explore the mechanism of the OK lens. METHODS Changes in diopter and axial length were collected among 70 adolescent myopia patients (124 eyes) wearing OK lenses for 1 year (group A) and 59 adolescent myopia patients (113 eyes) wearing frame glasses (group B). Refractive states of their retina were inspected through multispectral refraction topography. The obtained hyperopic defocus was analyzed for the mechanism of OK lenses on slowing down the increase of myopic diopter by delaying the increase of ocular axis length and reducing the near hyperopia defocus. RESULTS Teenagers in groups A and B were divided into low myopia (0D - -3.00 D) and moderate myopia (-3.25D - -6.00 D), without statistical differences among gender and age. After 1-year treatment, the increase of diopter and axis length and changes of retinal hyperopic defocus amount of group A were significantly less than those of group B. According to the multiple linear analysis, the retinal defocus in the upper, lower, nasal, and temporal directions had almost the same effect on the total defocus. The amount of peripheral retinal defocus (15°-53°) in group A was significantly lower than that in group B. CONCLUSION Multispectral refraction topography is progressive and instructive in clinical prevention and control of myopia.

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Section: Discussionsupporting

confidence: 74%

Novel application of multispectral refraction topography in the observation of myopic control effect by orthokeratology lens in adolescents

Ni¹,

Wang

et al. 2021

WJCC

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“…Long et al [45] reported that the increase in AL after 1 year was 0.05 ± 0.19 mm in the OK group and 0.34 ± 0.21 mm in the control group; the AL difference had a decrease of 0.29 mm. Na et al [38] also reported a one-year AL increase of 0.07 ± 0.21 mm in the OK group and 0.36 ± 0.23 mm in the control group; the AL difference decreased to 0.29 mm. Whereas, Chen et al [46] reported a difference of 0.42 mm in AL elongation between myopic and nonmyopic eyes after wearing OK lenses for 12 months.…”

Section: Discussionmentioning

confidence: 97%

“…The potential of OK lenses for myopic correction and control has been confirmed by several studies [25, 35-37]. Interestingly, OK lenses have demonstrated a beneficial effect against the progression of anisomyopia [38]. Wearing OK lenses for a long period of time would present a more significant AL difference reduction in children with severe anisometropia [39, 40].…”

Section: Introductionmentioning

confidence: 99%

Effects of Orthokeratology on Axial Length Elongation in Anisometropes

Bei

Qingmei

et al. 2021

Ophthalmic Res

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Introduction: This study aimed to investigate the therapeutic effects of overnight orthokeratology (OK) lenses on anisometropes. Methods: We enrolled 178 anisometropes from August 2015 to August 2017. We then divided these patients into 2 parts depending on them wearing either monocular or binocular OK lenses. In part one, 47 monocular myopic subjects (25 males and 22 females) were treated with OK lenses in the myopic eyes only. We also labeled the myopic eyes as the OK group and the contralateral nonmyopic eyes as the control group. The initial average wearing age of the subjects was 12.35 ± 2.37 years (8–16 years). The mean follow-up duration was 15.43 ± 4.88 months (7–25 months). The average spherical equivalent refraction (SER) was −2.31 ± 1.16 diopter (D) in the OK group and 0.15 ± 0.49 D in the control group (p < 0.001). In part 2, 131 binocular myopic anisometropes (56 males and 75 females) were involved in the study. The eyes with more severe myopia were assigned to the G group and the contralateral eyes to the L group. The initial average wearing age of the subjects was 12.92 ± 2.60 years ( 8–16 years). The mean follow-up duration was 17.83 ± 5.02 months (7–26 months). The average SER was −4.79 ± 1.90 D in the G group and −3.14 ± 1.88 D in the L group (p < 0.001). We calculated the axial length (AL) difference and AL elongation as our primary outcome measures. Results: In part one, the AL elongation in the OK group (0.21 ± 0.09 mm) was significantly lower than that in the control group (0.70 ± 0.17 mm) at 24 months (p < 0.001). Meanwhile, the AL difference exhibited a decrease of 0.50 ± 0.29 mm from a baseline of 1.08 ± 0.35 to 0.58 ± 0.25 mm at 24 months (F = 24.539, p < 0.001). In part 2, the AL had increased by 0.17 ± 0.13 mm in the G group and 0.24 ± 0.18 mm in the L group after 24-month follow-up, respectively (p < 0.001). While the AL difference decreased from 0.55 ± 0.11 mm at the baseline, to 0.48 ± 0.08 mm at 24 months, eliciting a decrement in AL difference of 0.07 ± 0.09 mm (F = 3.884, p = 0.030). Conclusions: OK lenses can slow down AL growth in anisometropes and has a greater effect on reducing AL elongation in the more severely affected myopic eyes of anisometropic patients.

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“…OK lenses are custom-designed rigid contact lenses that reshape the cornea to reduce refractive error. Wearing OK lenses overnight reduces the need for patients to wear contact lenses or spectacles in the daytime [ 26 , 27 , 28 , 29 , 30 ]. However, OK lenses can cause higher-order aberrations and lowered contrast sensitivity [ 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

The Synergistic Effects of Orthokeratology and Atropine in Slowing the Progression of Myopia

Wan

Wei

Chen

et al. 2018

JCM

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Atropine and orthokeratology (OK) are both effective in slowing the progression of myopia. In the current study, we studied the combined effects of atropine and OK lenses on slowing the progression of myopia. This retrospective study included 84 patients who wore OK lenses and received atropine treatment (OA) and 95 patients who wore OK lenses alone (OK) for 2 years. We stratified patients into low (<6 D, LM) and high (≥6 D, HM) myopia groups, as well as two different atropine concentrations (0.125% and 0.025%). Significantly better LM control was observed in OA1 patients, compared with OK1 patients. Axial length was significantly shorter in the OA1 group (24.67 ± 1.53 mm) than in the OK1 group (24.9 ± 1.98 mm) (p = 0.042); similarly, it was shorter in the OA2 group (24.73 ± 1.53 mm) than in the OK2 group (25.01 ± 1.26 mm) (p = 0.031). For the HM patients, OA3 patients compared with OK3 patients, axial length was significantly shorter in the OA3 group (25.78 ± 1.46 mm) than in the OK3 group (25.93 ± 1.94 mm) (p = 0.021); similarly, it was shorter in the OA4 patients (25.86 ± 1.21 mm) than in the OK4 patients (26.05 ± 1.57 mm) (p = 0.011). Combined treatment with atropine and OK lenses would be a choice of treatment to control the development of myopia.

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The effect of orthokeratology on axial length elongation in children with myopia: Contralateral comparison study

Abstract: Using a contralateral eye study design, which prevented the influence of potential confounding factors, Effectiveness of the OK lens was proved. Myopic progression within a subject was excellent compared with no intervention.

Cited by 22 publications

References 23 publications

Novel application of multispectral refraction topography in the observation of myopic control effect by orthokeratology lens in adolescents

Novel application of multispectral refraction topography in the observation of myopic control effect by orthokeratology lens in adolescents

Effects of Orthokeratology on Axial Length Elongation in Anisometropes

The Synergistic Effects of Orthokeratology and Atropine in Slowing the Progression of Myopia

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