The effect of osteoimmunomodulation on the osteogenic effects of cobalt incorporated β-tricalcium phosphate

Chen, Zetao; Yuen, Jones; Crawford, Ross; Chang, Jiang; Wu, Chengtie; Xiao, Yin

doi:10.1016/j.biomaterials.2015.04.044

Cited by 184 publications

(146 citation statements)

References 47 publications

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“…When developing coatings for orthopaedic applications one must, therefore, be mindful of immunomodulatory effects that encourages osteogenesis. The term "osteoimmunomodulatory property" has been proposed to describe this process [19][20][21]. Coating materials that optimizes osteoimmunomodulation can induce an inflammatory response that balances osteogenesis and osteoclastogenesis in such a way that it favours bone regeneration.…”

Section: A N U S C R I P Tmentioning

confidence: 99%

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Clinoenstatite coatings have high bonding strength, bioactive ion release, and osteoimmunomodulatory effects that enhance in vivo osseointegration

Chen

et al. 2015

Biomaterials

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Section: A N U S C R I P Tmentioning

confidence: 99%

“…Three cell types, the RAW 264.7 (RAW) cells (a murine-derived macrophage cell line), osteoclasts and BMSCs were applied in this study [21,25]. Isolation and culutre of BMSCs were performed based on published protocols [19,20,37].…”

Section: Cell Culturementioning

confidence: 99%

Clinoenstatite coatings have high bonding strength, bioactive ion release, and osteoimmunomodulatory effects that enhance in vivo osseointegration

Chen

et al. 2015

Biomaterials

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“…Acellular matrices were shown to elicit a predominantly M2 type response and resulted in constructive remodelling, while those containing a cellular component presented M1 polarization response leading to deposition of dense connective tissue and scarring 147 . Very recently, a novel approach to assess osteogenesis in vitro has been proposed by Chen et al 148 . In their study the osteogenic capacity of cobalt incorporated with β-tricalcium phosphate (TCP) was assessed using a coculture of MSCs and macrophages and compared with the traditional “one cell type” method.…”

Section: Designing Biointeractive Coatings To Support Implant Intementioning

confidence: 99%

Tailoring biomaterial surface properties to modulate host-implant interactions: implication in cardiovascular and bone therapy

et al. 2016

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Host body response to a foreign medical device plays a critical role in defining its fate post implantation. It is thus important to control host-material interactions by designing innovative implant surfaces. In the recent years, biochemical and topographical features have been explored as main target to produce this new type of bioinert or bioresponsive implants. The review discusses specific biofunctional materials and strategies to achieve a precise control over implant surface properties and presents possible solutions to develop next generation of implants, particularly in the fields of bone and cardiovascular therapy.

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“…The calcium nodule staining was photoed by Canon DSLR camera [41]. The mineralized nodules were dissolved by hexadecylpyridinium chloride and the OD values were obtained at 562 nm for quantitative data [42,43]. …”

Section: Methodsmentioning

confidence: 99%

PNIPAAM modified mesoporous hydroxyapatite for sustained osteogenic drug release and promoting cell attachment

Tan

Cheng

et al. 2016

Materials Science and Engineering: C

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This work presented a sustained release system of simvastatin (SIM) based on the mesoporous hydroxyapatite (MHA) capped with poly(N-isopropylacrylamide) (PNIPAAM). The MHA was prepared by using cetyltrimethylammonium bromide (CTAB) as a template and the modified PNIPAAM layer on the surface of MHA was fabricated through surface-initiated atom transfer radical polymerization (SI-ATRP). The SIM loaded MHA-PNIPAAM showed a sustained release of SIM at 37 °C over 16 days. The bone marrow mesenchymal stem cell (BMSC) proliferation was assessed by cell counting kit-8 (CCK-8) assay, and the osteogenic differentiation was evaluated by alkaline phosphatase (ALP) activity and Alizarin Red staining. The release profile showed that the release of SIM from MHA-SIM-PNIPAAM lasted 16 days and the cumulative amount of released SIM was almost seven-fold than MHA-SIM. Besides, SIM loaded MHA-PNIPAAM exhibited better performance on cell proliferation, ALP activity, and calcium deposition than pure MHA due to the sustained release of SIM. The quantity of ALP in MHA-SIM-PNIPAAM group was more than two fold than pure MHA group at 7 days. Compared to pure MHA, better BMSC attachment on PNIPAAM modified MHA was observed using fluorescent microscopy, indicating the better biocompatibility of MHA-PNIPAAM.

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The effect of osteoimmunomodulation on the osteogenic effects of cobalt incorporated β-tricalcium phosphate

Cited by 184 publications

References 47 publications

Clinoenstatite coatings have high bonding strength, bioactive ion release, and osteoimmunomodulatory effects that enhance in vivo osseointegration

Clinoenstatite coatings have high bonding strength, bioactive ion release, and osteoimmunomodulatory effects that enhance in vivo osseointegration

Tailoring biomaterial surface properties to modulate host-implant interactions: implication in cardiovascular and bone therapy

PNIPAAM modified mesoporous hydroxyapatite for sustained osteogenic drug release and promoting cell attachment

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