The effect of ovarian follicle size on oocyte and embryology outcomes

Shapiro, B.S.; Rasouli, Melody A.; Verma, Kajal; Raman, Ankita; Garner, Forest C.; Aguirre, M.; Kaye, Leah; Bedient, Carrie E.

doi:10.1016/j.fertnstert.2022.02.017

Cited by 17 publications

(8 citation statements)

References 25 publications

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“…This may be responsible for the ultimate increase in the number of implantation sites because oocytes obtained from large follicles had a better developmental capacity. 64,65 Notably, consistent with previous studies, 10,66 although methionine supplementation was beneficial for the reproductive performance of rats, the use of high doses of methionine negatively affected embryo implantation and follicular development, as demonstrated in our results.…”

Section: Food and Function Papersupporting

confidence: 92%

Dietary methionine supplementation during the estrous cycle improves follicular development and estrogen synthesis in rats

Yang,

Li,

Cai

et al. 2024

Food Funct.

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Section: Food and Function Papersupporting

confidence: 92%

Dietary methionine supplementation during the estrous cycle improves follicular development and estrogen synthesis in rats

Yang,

Li,

Cai

et al. 2024

Food Funct.

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“…Similarly, Shapiro et al have shown that retrieval of follicles 10-12.5 mm size during OPU was associated with a significant reduction in the total and MII oocyte retrieval rate. In the same study, follicle size of 19-21.5 mm was associated with the best rates for MII oocytes (11). Hence, it may be reasonable to extend the duration of stimulation to have a larger follicular pool to obtain more viable embryos (12,21,22).…”

Section: Discussionmentioning

confidence: 76%

“…While some studies claimed that follicle diameter of [? ]16 mm leads to higher pregnancy rates due to optimized growth factors and steroid hormones in the follicular fluid (8)(9)(10)(11), other studies have shown no differences between follicle size and embryo quality and/or implantation rate (12,13). In ART cycles, the timing of trigger usually depends on the size of the leading follicle/s, which is mainly accepted as > 17-18 mm.…”

Section: Introductionmentioning

confidence: 99%

Optimal leading follicle size for final oocyte maturation in POSEIDON group 3 and 4 poor responders undergoing assisted reproductive technology cycles.

Akgün,

Şükür,

Aslan

et al. 2024

Preprint

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Objective: To determine the optimal leading follicle size for triggering final oocyte maturation in POSEIDON groups 3 and 4 poor responders undergoing ART cycles. Design: Retrospective cohort study. Setting: University based Infertility Centre. Population: Data of 294 POSEIDON groups 3 and 4 poor responders aged between 20 and 42 years who underwent ICSI following a GnRH antagonist cycle between January 2015 and July 2021 were reviewed. Methods: Among the 342 patients eligible in our database, 294 fulfilling inclusion criteria were assessed for final analyses. Cycles were categorized into two groups according to occurrence of premature ovulation. Premature ovulation was defined as visualization of rupture of at least one of the leading follicles on the day of oocyte retrieval. In addition, number of oocytes retrieved, number of MII oocytes, MII/antral follicle count (AFC) ratio and follicle-oocyte index (FOI) were compared between different leading follicle sizes. Main Outcome Measures: Number of oocytes retrieved, number of MII oocytes, MII/antral follicle count (AFC) ratio and follicle-oocyte index (FOI). Results: Among all, 47 (16.2%) had premature ovulation between the trigger and oocyte pick-up days. The mean size of the leading follicle on the day of trigger was significantly higher in the premature ovulation group than the controls (19.8±2.4 mm vs.18.7±2 mm, respectively; P<0.001). Multivariate logistic regression analyses identified baseline LH (Odds ratio {OR} 1.144, 95% confidence interval {CI} 1.052-1.243; P=0.002), number of follicles >11 mm on the day of trigger (OR 0.580, 95% CI 0.438-0.767; P<0.001), and leading follicle size (OR 1.361, 95% CI 1.130-1.641; P=0.001) as independent predictors of premature ovulation. According to the one-way ANOVA test and non-linear curve estimation model the FOI and MII/AFC ratios peaked when the leading follicle size was between 16-17 mm, respectively. Conclusion: Individualized trigger based on leading follicle size can provide maximum efficiency in ovarian stimulation in POSEIDON expected poor responders. While late trigger may result in premature ovulation, early trigger may also result in less MII. Triggering when the leading follicle size is between 16.5 and 17 mm can help to prevent these negative outcomes and achieve optimal cycle outcome.

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“…A recent study in such young and unselected women undergoing IVF, indeed, suggested that follicle sizes under 12.5 mm at the time of retrieval (likely representing trigger sizes of 9-11 mm) rarely result in good-quality blastocysts. 21 …”

Section: Discussionmentioning

confidence: 99%

Changing clinical significance of oocyte maturity grades with advancing female age advances precision medicine in IVF

Nicholas,

Darmon,

Patrizio

et al. 2023

iScience

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The effect of ovarian follicle size on oocyte and embryology outcomes

Cited by 17 publications

References 25 publications

Dietary methionine supplementation during the estrous cycle improves follicular development and estrogen synthesis in rats

Dietary methionine supplementation during the estrous cycle improves follicular development and estrogen synthesis in rats

Optimal leading follicle size for final oocyte maturation in POSEIDON group 3 and 4 poor responders undergoing assisted reproductive technology cycles.

Changing clinical significance of oocyte maturity grades with advancing female age advances precision medicine in IVF

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