The effect of ovarian puncture on the endocrine profile of PCOS patients who undergo IVM

Abstract

BackgroundTo examine whether ovarian puncture for immature oocyte retrieval and in-vitro maturation (IVM) has an effect on the endocrine profile of patients with polycystic ovary syndrome (PCOS).MethodsTwenty-two consecutive patients with PCOS undergoing IVM treatment were included. Serum anti-Müllerian hormone (AMH), sex hormone-binding globulin (SHBG), total testosterone (TT) and luteinized hormone (LH) levels were analyzed at the start of the cycle, on the day of immature oocyte retrieval (OR) and at fixed intervals thereafter, for up to three months after OR.ResultsFive days after OR circulating AMH, TT, calculated free testosterone (FTc), and LH levels were significantly reduced and circulating SHBG was significantly increased. Two weeks after OR, TT, FTc and LH remained reduced, whereas circulating AMH and SHBG levels recovered to pre-puncture values. Three months after OR, all circulating hormone levels had recovered to baseline values.ConclusionOvarian puncture for the retrieval of immature oocytes and IVM in patients with PCOS has a significant impact on the ovarian endocrine profile, but this impact is brief and transient.

Designing and evaluating autoverification rules for thyroid function profiles and sex hormone tests

“…the menstrual cycle, ART. 27,28 Therefore, we believe that caution is needed in the interpretation of test results for sex hormones.…”

“…25,26 Circulating concentrations of sex hormones can also vary with the menstrual cycle and in patients undergoing treatment through assisted reproductive technology (ART). In those women receiving ART, circulating sex hormone concentrations differ from those found in normal or pregnant women, 27,28 presenting a challenge for the setting of any autoverification rules. 26,[29][30][31][32] In this study, we present a detailed description of how to construct autoverification rules for thyroid function and sex hormone tests using the DM2 middleware, and describe their subsequent validation and evaluation in the clinic.…”

In Vitro Maturation and Fertilization of Oocytes: From Laboratory Bench to Clinical Practice

“…It seems that in PCOS patient, IVM is a simple, less stressful, and economical protocol of treatment. The puncture is simple and safe, and it may improve the disrupted endocrine environment and induce a spontaneous recovery of ovulation in women with PCOS [46]. It can also avoid short-term complications, such as OHSS, and elude massive hormonal stimulation and long-term complications, such as hormone-dependent neoplasms including breast and ovarian cancer.…”

In Vitro Matitration of oocytes. Indication, technique and results

“…По-видимому, у пациенток с СПКЯ IVM является простым, менее напряженным и более экономичным протоколом лечения. Пункция проста и безопасна, может способствовать улучшению нарушенного эндокринного баланса и привести к спонтанному восстановлению овуляции у пациенток с СПКЯ [30]. IVM также позволяет избежать непосредственных осложнений, таких как СГЯ, а также ввиду отсутствия массивной гормональной стимуляции исключает риск отдаленных осложнений, таких как гормон-зависимые неоплазии, включая рак молочной железы и яичников.…”