The effect of ovariectomy on mandibular cortical thickness in the rat

Yang, Jie; Farnell, Damian J. J.; Devlin, Hugh; Horner, Keith; Graham, Jim

doi:10.1016/j.jdent.2004.09.001

Cited by 35 publications

(30 citation statements)

References 19 publications

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“…The point at which its bone mass peaks is also similar to that of standard strains at 4 to 5 months old, making it a useful strain for SO modeling [12][13][14][15] . On the other hand, many studies have focused on the pathology and treatment of PO due to the relative ease of creating an experimental animal disease model via ovariectomy (OVX) 16,17) . With this in mind, the present study sought to demonstrate the effect of complex onset of PO and SO on the tibia and alveolar bone by creating an ovariectomized SAMP6 mice and investigating the site specificity of trabecular structure in alveolar and tibial bone.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ovariectomy on the Tibia and Alveolar Bone in a Senescence-Accelerated Mouse-Prone 6 (SAMP6) Model

Matsunaga

Maki

Noguchi

et al. 2016

J. Hard Tissue Biology.

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Recent investigations on osteoporosis have led to a better understanding of the pathology and treatment of the disease. However, the decline in sex hormones that typically accompanies aging makes it difficult to separately investigate the complex factors that cause the disease in humans. Various animal-based studies have demonstrated the pathology of senile osteoporosis (SO) and postmenopausal osteoporosis (PO), but a number of uncertainties remain as to the pathology behind the occurrence of both conditions. In the present study, we prepared ovariectomized senescence-accelerated mouse-prone 6 (SAMP6) mice and investigated the site specificity of trabecular structural properties in alveolar and tibial bone. The experimental animals were the SAMP6 mice (n = 10), while SAM-resistant/1 (SAMR1) mice (n = 10) served as controls. All mice were ovariectomized at 16 weeks of age and sacrificed at Week 17 and 20. The tibia and mandible bone samples were extracted and scanned using micro-computed tomography and subjected to bone morphometry. The results showed that trabecular bone was significantly thinner in the ovariectomized SAMP6 mice than in the ovariectomized SAMR1 mice at 17 weeks, but at 20 weeks, there were no significant differences in the tibial bone. In terms of alveolar bone, there were no significant differences in bone morphometry findings at week 17 but bone volume fraction and trabecular bone pattern factor values were significantly lower in the ovariectomized SAMP6 mice than in the ovariectomized SAMR1 mice at 20 weeks. The results therefore suggest that single onset of either PO or SO has little impact on alveolar bone but complex SO/PO onset causes severe alveolar bone resorption.

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Section: Introductionmentioning

confidence: 99%

Effect of Ovariectomy on the Tibia and Alveolar Bone in a Senescence-Accelerated Mouse-Prone 6 (SAMP6) Model

Matsunaga

Maki

Noguchi

et al. 2016

J. Hard Tissue Biology.

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“…Estrogen deficiency causes osteoporosis, which is associated with the enhancement of bone remodeling soon after ovariectomy. In another study, long-term estrogen deficiency in ovariectomized rats decreased the mandibular cortical thickness 18) . Loza et al 2) examined the relationship between osteoporosis and intraoral bone tissues and reported that the alveolar bone loss in the presence of progressed periodontal disease is more significant in men than with in women, suggesting that hormones and habitual factors such as drinking and smoking affect men more seriously than osteoporosis in women.…”

Section: ⅳ Discussionmentioning

confidence: 90%

The effect of estrogen deficiency on rat pulpodentinal complex

Kim

Yang

Baek

et al. 2005

J Korean Acad Conserv Dent

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The purpose of this study was to investigate the effects of estrogen deficiency on pulpodentinal complex of tooth in ovariectomized rats. Thirty female Sprague-Dawley rats, 10 weeks old, were used. Rats were grouped into two groups. One group (n = 15) was subjected to sham surgery (SHAM) and the other group (n = 15) was ovariectomized bilaterally (OVX). Animals were sacrificed 12 weeks later, and their mandibular molars and associated periodontal supporting tissues were dissected out, and fixed in 10% buffered formalin. For comparison of groups, immunostained for osteonectin. Histomorphometrical measurement of change of teeth was performed using an image analysis system and paired t-test was used and the level of significance for overall differences was set at p < 0.05.In immunostaining of osteonectin, they were significantly different from each other. The predentin thickness in OVX rats was wider than in SHAM rats. And in SHAM rats, osteonectin was more specifically stained in predentin areas than in OVX rats. These results indicate that estrogen deficiency increased the unmineralized predentin areas and decreased osteonectin content in pulpal tissues in rats. If our result is applicable to human studies, odotoblast is affected by estrogen deficiency. [J Kor Acad Cons Dent 30(5): [402][403][404][405][406][407][408] 2005]

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“…2,3) Many studies have focused on the pathophysiology and treatment of post-menopausal osteoporosis (PMO), as it is relatively easy to create an animal disease model via ovariectomy. For example, Tanaka et al 4) and Yang et al 5) reported morphological changes such as decreased bone volume and cortical bone thinning in the mandibles of ovariectomized (OVX) rats. Meanwhile, an in vivo study by Takeda et al 6,7) on senile osteoporosis (SO; also a primary form of the disease) used the P6 substrain of senescence-accelerated (SAMP6) mice obtained through selective breeding.…”

Section: )mentioning

confidence: 99%

A Site-Specific Comparison of the Trabecular Structure in Senescence-Accelerated Mice^|^mdash;Evaluation of Time-Course Changes in Bone Architecture using in Vivo Micro-CT^|^mdash;

Noguchi

Matsunaga

Kinoshita

et al. 2013

J. Hard Tissue Biology.

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Recent research on osteoporosis has led to a number of advances in our understanding of its pathophysiology and treatment. However, much is still unknown, and a consensus is yet to be reached on how osteoporosis affects the jaw. With this in mind, the present study sought to identify changes over time in the mandibular cancellous bone of senile osteoporotic mice by assessing the trabecular structure in their mandible and tibia. The senescence-accelerated mouse strain P6 (SAMP6) (n = 5) was used as the experimental model, whereas the senescence-accelerated mouse strain R1 (SAMR1) served as control (n = 5). All mice were aged 16 weeks. Bone morphometry was performed by taking a series of micro-computed tomography (micro-CT) scans of the same animal at different time points. As a result, the morphometric parameters of bone volume fraction (BV/TV), trabecular thickness (Tb.Th) and trabecular number (Tb.N) in the tibias of the SAMP6 mice were significantly lower than those of the SAMR1 mice. Conversely, there were no consistent differences in these parameters in the jaw bones of SAMP6 or SAMR1 mice. These findings may suggest that relevant load-bearing teeth protect the alveolar bone structure from the degenerative effects of osteoporosis.

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The effect of ovariectomy on mandibular cortical thickness in the rat

Cited by 35 publications

References 19 publications

Effect of Ovariectomy on the Tibia and Alveolar Bone in a Senescence-Accelerated Mouse-Prone 6 (SAMP6) Model

Effect of Ovariectomy on the Tibia and Alveolar Bone in a Senescence-Accelerated Mouse-Prone 6 (SAMP6) Model

The effect of estrogen deficiency on rat pulpodentinal complex

A Site-Specific Comparison of the Trabecular Structure in Senescence-Accelerated Mice^|^mdash;Evaluation of Time-Course Changes in Bone Architecture using in Vivo Micro-CT^|^mdash;

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