The Effect of Over-Expression of miR-20a on Cell Proliferation of Human T Cell Leukemia Cell Line

M, Razavi Hashemi; Vahabpour, Rohollah; Ranji, Najmeh; Sanati, MH; M, Mapar; Sadat, Seyed Mehdi

doi:10.7754/clin.lab.2018.180406

Cited by 1 publication

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“…Also, it has been demonstrated that the expression of miR‐20a is decreased in T cells from acute T‐cell leukemia, as an aggressive type of blood cancer. In addition, the upregulation of miR‐20a contributes to the arrest of cancerous T cells in the G0/G1 phase (M et al, 2018). Dysregulation of miRNAs has been investigated in cutaneous T‐cell lymphoma (CTCL).…”

Section: Mirnas In T‐cell Malignancesmentioning

confidence: 99%

microRNAs involved in T‐cell development, selection, activation, and hemostasis

Tapeh

Mosayyebi

Samei

et al. 2020

Journal Cellular Physiology

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MicroRNAs (miRNAs) characterized by small, noncoding RNAs have a fundamental role in the regulation of gene expression at the post‐transcriptional level. Additionally, miRNAs have recently been identified as potential regulators of various genes involved in the pathogenesis of the autoimmune and inflammatory disease. So far, the interaction between miRNAs and T lymphocytes in the immune response as a new and significant topic has not been emphasized substantially. The role of miRNAs in different biological processes including apoptosis, immune checkpoints and the activation of immune cells is still unclear. Aberrant miRNA expression profile affects various aspects of T‐cell function. Accordingly, in this literature review, we summarized the role of significant miRNAs in T‐cell development processes. Consequently, we demonstrated precise mechanisms that candidate miRNAs interfere in Immune response mediated by different types of T cells. We believe that a good understanding of the interaction between miRNAs and immune response contributes to the new therapeutic strategies in relation to disease with an immunological origin.

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Section: Mirnas In T‐cell Malignancesmentioning

confidence: 99%