The effect of oxaliplatin on heart tissue of the rats

Abstract

Aim: This study investigates the cardiotoxicity of Oxaliplatin (OXA) on rat heart by using oxidative stress parameters on myocardium and troponin I and S100A1 levels of serum. Material and Method: Acute OXA treatment (4 mg/kg/1 st , 3 rd and 5 th days) has been administered to the 6-8 months old rats. The heart and serum samples were obtained at 7 th and 14 th days of the study. Chronic OXA treatment was (4 mg/kg/two days of week/4 weeks) administered, rats were sacrificed and heart and serum samples were obtained at the 28 th day and at the 2 st day following the completing administration of drugs. Results: The results of all OXA treatment group's antioxidant levels and serum cardiotoxicity markers; troponin I and S100 A1 levels were not significantly different compared to the control group (p>0.05). Discussion: OXA did not produce significant oxidative myocardial damage when given 4 mg/kg in acute and chronic administration.Oxa treatment seems safe in terms of cardiotoxicity.

Investigating of Acute and Chronic Effects of Oxaliplatin on Rat Ocular Tissues

“…Six-8 month-old male Wistar albino rats, were obtained from Animal Care and Research Unit of University and all experiments were performed according to the principles and guidelines of Animal Ethical Committee after receival of its approval. This study was mainly planned to evaluate the ototoxic effect of OXA, but lung, heart (7) and eye tissues have been also evaluated with the aim to decrease the number of animal used in medical researches; after receiving relevant approval of the animal ethical committee (HADYEK, 64583101/2014/138). OXA (Eloxatin®, Sanofi, U.S.), the dose of 4 mg/kg has been diluted in 5% glucose solution just prior to intraperitoneal (i.p.)…”