The Effect of Oxidation on the Mechanical Response of Isolated Elastin and Aorta

Mythravaruni, P.; Ravindran, Parag

doi:10.1115/1.4043355

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…The UPE wavelengths obtained in the present study for elastin and phospholipids were similar to their reported fluorescence emission ranges 34 , 35 . UV-irradiated elastin was previously shown to produce hydrogen peroxide 36 and oxidation was reported to cause structural changes to elastin 37 . The effects of oxidized phospholipids suggest their potential relevance in different pathologies, including atherosclerosis, acute inflammation, lung injury, and many other conditions 38 .…”

Section: Discussionmentioning

confidence: 99%

Ultraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin

Tsuchida¹,

Kobayashi

2020

Sci Rep

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Oxidative stress is associated with photoaging of the skin as well as with skin cancer, and is therefore, critical to monitor. Ultraweak photon emission (UPE) is extremely weak light generated during the oxidative process in the living body and has been used as a non-invasive and label-free marker for the evaluation of oxidative stress. However, the mechanism of UPE generation is not clear. Therefore, we aimed to elucidate the molecular mechanism underlying UPE generation by analyzing the spectra of UPE generated from biomolecules in the skin during ultraviolet A (UVA) exposure. The spectra of UVA-induced UPE generated from linoleic acid, linolenic acid, elastin, phospholipids, and 5,6-dihydroxyindole-2-carboxylic acid were measured, and the spectrum of human skin tissue was also obtained. The spectral patterns varied for the different biomolecules and the peaks were distinct from those of the skin tissue. These results suggested that the UPE generated from skin tissue is a collection of light emitted by biomolecules. Moreover, we proposed that UPE is generated through a photosensitization reaction and energy transfer. The identified characteristic spectral patterns of UPE can be useful to elucidate UVA-induced oxidative stress in the skin, with implications for prevention and treatment of photoaging and skin diseases.

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Section: Discussionmentioning

confidence: 99%

Ultraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin

Tsuchida¹,

Kobayashi

2020

Sci Rep

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Continuum Thermodynamics of Constrained Reactive Mixtures

Ateshian

Zimmerman

2021

Journal of Biomechanical Engineering

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Mixture theory models continua consisting of multiple constituents with independent motions. In constrained mixtures all constituents share the same velocity but they may have different reference configurations. The theory of constrained reactive mixtures was formulated to analyze growth and remodeling in living biological tissues. It can also reproduce and extend classical frameworks of damage mechanics and viscoelasticity under isothermal conditions, when modeling bonds that can break and reform. This study focuses on establishing the thermodynamic foundations of constrained reactive mixtures under more general conditions, for arbitrary reactive processes where temperature varies in time and space. By incorporating general expressions for reaction kinetics, it is shown that the residual dissipation statement of the Clausius-Duhem inequality must include a reactive power density, while the axiom of energy balance must include a reactive heat supply density. Both of these functions are proportional to the molar production rate of a reaction, and they depend on the chemical potentials of the mixture constituents. We present novel formulas for the classical thermodynamic concepts of energy of formation and heat of reaction, making it possible to evaluate the heat supply generated by reactive processes from the knowledge of the specific free energy of mixture constituents as well as the reaction rate. We illustrate these novel concepts with mixtures of ideal gases, and isothermal reactive damage mechanics and viscoelasticity, as well as reactive thermoelasticity. This framework facilitates the analysis of reactive tissue biomechanics and physiological and biomedical engineering processes where temperature variations cannot be neglected.

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The Effect of Oxidation on the Mechanical Response of Isolated Elastin and Aorta

Cited by 2 publications

References 32 publications

Ultraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin

Ultraviolet A irradiation induces ultraweak photon emission with characteristic spectral patterns from biomolecules present in human skin

Continuum Thermodynamics of Constrained Reactive Mixtures

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