The Effect of Oxidizing Agents in the Preparation of 2,3,5‐triaryl‐2H‐tetrazolium Salts from 1,3,5‐triarylformazans

Abstract

in Wiley Online Library (wileyonlinelibrary.com).Tetrazolium salts are a group of versatile molecules with a relatively limited application due to synthesis difficulty and high cost of production. Here, we have comparatively examined several approaches for the preparation of 2-(4-nitrophenyl)-3,5-diphenyl-2H-tetrazolium chloride (NTC), as a model tetrazolium salt, through the oxidation of 1-(4-nitrophenyl)-3,5-diphenylformazan (NF), by means of interphase oxidation, dehydrogenation, and direct chlorination. Our findings indicate that chlorination of NF with 1-chlorobenztriazole to be the best choice to prepare NTC from small-scale and scaled-up considerations.

New directions for tetrazolium - gellan gum gel dosimeters

“…MBC was synthesized according to a previously published procedure using 4-methoxybezladehyde, 4nitrophenylhydrazine and 4-nitroaniline according to [8], whereas all other materials were purchased from commercial suppliers and used without further modification: BNC as "2,3-Bis(4-nitrophenyl)-5phenyltetrazolium chloride hydrate" (cat. no.…”