The effect of oxpentifylline (Trental') on fibrinolytic activity and plasma fibrinogen levels

Pe, Jarret; Moreland, Michelle; Nl, Browse

doi:10.1185/03007997709109338

Cited by 58 publications

(13 citation statements)

References 5 publications

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“…Four weeks oral therapy has also been reported to increase CBF in patients with dementia, but this study was not blind and the patients did not act as their own controls, diminishing the value of the results (Hartmann, 1981). Prolonged oral therapy with oxpentifylline also lowers fibrinogen in normal volunteers (Jarrett et al, 1977).…”

Section: Discussionmentioning

confidence: 90%

Effect of oxpentifylline on blood viscosity and cerebral blood flow in man.

Brown

1989

Brit J Clinical Pharma

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The effects of intravenous oxpentifylline on blood viscosity and cerebral blood flow were studied in eight patients with cerebrovascular disease using a double‐blind placebo controlled design. A single dose of 200 mg oxpentifylline in 10 ml saline was given by intravenous injection over 10 min and compared with 10 ml saline alone. Whole blood and plasma viscosity were measured in a Contraves LS 30 coaxial viscometer at shear rates of 0.7 and 94.5 s‐1. Cerebral blood flow was measured by the non‐invasive intravenous xenon133 clearance method. The measurements were made before and then 30 min after the start of the injection of drug or saline alone. Oxpentifylline was found to have no significant effect on blood viscosity or cerebral blood flow.

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Section: Discussionmentioning

confidence: 90%

Effect of oxpentifylline on blood viscosity and cerebral blood flow in man.

Brown

1989

Brit J Clinical Pharma

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“…The anti-platelet action of PTX, mediated by the release of prostacyclin from the endothelial cells is also well documented (Gastpar et al, 1978;Ambrus et al, 1979;Weithmann, 1981). In addition, the release of prostacyclin stimulates fibrinolysis (Jarrett et al, 1977 For PTX to exert an effect we are assuming that the viscosity must be raised, since there is no direct evidence that PTX affects the in vivo blood viscosity under normal conditions. Attempts to measure the blood viscosity proved to be unreliable, due to the time lapse between sampling and measurement and the change in the environmental conditions of the blood, a phenomenon that has been experienced before (Hirst & Wood, personal communication).…”

Section: Resultsmentioning

confidence: 99%

“…The methyl xanthine derivative, pentoxifylline (PTX), a drug used clinically for the treatment of intermittent claudication and peripheral vascular disease, is known to lower blood viscosity both directly, by increasing the deformability of erythrocytes (Dormandy et al, 1981;Carr & Hauge, 1990), and indirectly, by preventing the formation of clusters of red cells, or rouleaux, via the stimulation of fibrinolysis resulting from the release of prostacyclin from the endothelial cells (Jarrett et al, 1977;Muller, 1979;Matzky et al, 1982). By reducing the rigidity of the red cells, their passage through small arterioles and capillaries, such as those present in the tumour microcirculation, is improved.…”

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confidence: 99%

The effects of pentoxifylline on the relative perfusion of tumours growing in three sites in the mouse

Sensky

Prise²,

Ward³

et al. 1993

Br J Cancer

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Summary The haemorheological agent pentoxifylline (PTX) has been shown to improve the relative perfusion and oxygenation of subcutaneous tumours in the mouse. In order to establish whether this effect is dependent on the site of tumour growth, we have looked at changes in the distribution of the cardiac output (COD) to the murine NT carcinoma grown either intradermally (i.d.), intramuscularly (i.m.), on the wall of the caecum, or in all three sites, following i.p. administration of 50 mg kg-' PTX. In animals bearing a single tumour, PTX treatment significantly increases the COD to tumours located in the caecum, but has no significant effect on the COD to those located in the i.d. or i.m. sites. If all three tumours are present in a single animal, the COD to all three tumours is significantly enhanced by PTX. This appears to reflect the presence of the caecum tumour and does not appear to relate to changes in tumour size or to the haematocrit (HCT) of the blood. We propose that this site dependency implies that a significant increase in blood viscosity only occurs in animals with tumours located in specific sites. Therefore, the potential radiosensitising capability of PTX is highly dependent on tumour location.

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“…Eventually, pentoxifylline improves the flow properties of blood by decreasing its viscosity (Jarret et al 1977;Schroer 1985). If pentoxifylline increases local (peritoneal) fibrinolytic activity, it possibly reduces peritoneal adhesions.…”

mentioning

confidence: 99%

“…Pentoxifylline, a methyl xanthine derivative, enhances plasma fibrinolytic activity, reduces plasma fibrinogen levels, inhibits platelet aggregation and increases erythrocyte and leukocyte flexibility (Jarret et al 1977;Alkharfy et al 2000;Schroer 1985). Eventually, pentoxifylline improves the flow properties of blood by decreasing its viscosity (Jarret et al 1977;Schroer 1985).…”

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confidence: 99%

Pentoxifylline, a Methyl Xanthine Derivative, Reduces Peritoneal Adhesions and Increases Peritoneal Fibrinolysis in Rats

Tarhan

Barut

Sütçü

et al. 2006

Tohoku J. Exp. Med.

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Peritoneum has an intrinsic fibrinolytic activity that breaks the peritoneal adhesions. Peritoneal injuries with ischemia interfere this fibrinolytic activity and cause adhesions. Pentoxifylline, a methyl xanthine derivative, improves blood flow by decreasing its viscosity and also increases fibrinolytic activity in plasma. We hypothesized that pentoxifylline would increase peritoneal fibrinolysis and ameliorate adhesions. A rat model of peritoneal adhesion (cecal abrasion with gauze, n = 15 for each group) was used to test this hypothesis and cardinal parameters of peritoneal fibrinolysis were measured in peritoneal samples. No medication was given in control animals, while pentoxifylline was administered intraperitonealy (IP) (25 mg/kg, before abdominal closure to whole abdomen) or intravenously (IV) (25 mg/kg, for 9 days after operation) in the experimental groups. At postoperative day 10, peritoneal biopsies were obtained and adhesions were graded qualitatively. Activities and concentrations of tissue plasminogen activator (tPA), plasminogen activator inhibitor type 1 (PAI-1), tPA/PAI-1 complex and hydroxyproline contents were determined. Total adhesion scores were decreased in both treated groups. Mean levels of tPA concentration and tPA activity were increased in the treated groups compared to controls ( p < 0.001 and p = 0.001, respectively). The tPA/PAI-1 complex levels were similar among the three groups. PAI-1 levels were lower in animals receiving IP pentoxifylline compared to control animals and those treated with IV pentoxifylline ( p = 0.048, p = 0.015, respectively). Peritoneal hydroxyproline levels were similar among the three groups. Our results suggest that pentoxifylline administration either through IV or IP may reduce peritoneal adhesion formation probably by altering peritoneal fibrinolytic activity.pentoxifylline; peritoneal adhesion; tPA; PAI-1; peritoneal fibrinolysis

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The effect of oxpentifylline (Trental') on fibrinolytic activity and plasma fibrinogen levels

Cited by 58 publications

References 5 publications

Effect of oxpentifylline on blood viscosity and cerebral blood flow in man.

Effect of oxpentifylline on blood viscosity and cerebral blood flow in man.

The effects of pentoxifylline on the relative perfusion of tumours growing in three sites in the mouse

Pentoxifylline, a Methyl Xanthine Derivative, Reduces Peritoneal Adhesions and Increases Peritoneal Fibrinolysis in Rats

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