The effect of oxygenated water in Diabetes Mellitus

Handajani, Yvonne Suzy; Tenggara, Riki; Suyatna, Fransiscus D.; Surjadi, Charles; Widjaja, Nelly Tina

doi:10.13181/mji.v18i2.351

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…DM subjects with normal nutritional states also had a greater tendency for malondialdehyde (MDA) reduction after consuming oxygenated water for 45 days. Most subjects felt healthier after consuming oxygenated water [7]. Based on these studies, we believe that oxygenated water might improve cellular metabolism.…”

Section: Introductionmentioning

confidence: 77%

Effects of Highly Oxygenated Water in a Hyperuricemia Rat Model

Fang

Tsai

Shyong

et al. 2020

Journal of Healthcare Engineering

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Recent years have seen a rapidly rising number of oxygenated water brands that claim to impart health benefits and increase athletic performance by improving oxygen availability in the body. Drinks with higher dissolved oxygen concentrations have in recent times gained popularity as potential ergogenic aids, despite the lack of evidence regarding their efficacy. The aim of this study was to characterize oxygenated water and assess the improvement in uric acid metabolism while identifying performance enhancements in animals administered oxygenated water. Oxygenated water was characterized by hydrogen and oxygen nuclear magnetic resonance (NMR) spectroscopy. Hyperuricemia in rats was induced by treatment with oxonic acid potassium salt, and the animals were given oxygenated drinking water before, during, or after oxonic acid treatment. Serum uric acid was measured to confirm the effects on uric acid metabolism. Following oxygenation, the full width at half maximum (FWHM) was reduced to 11.56 Hz and 64.16 Hz in the hydrogen and oxygen NMR spectra, respectively. Oxygenated water molecule clusters were reduced in size due to the reduction in FWHM. Oxygen concentration did not vary significantly with increased temperature. However, standing time played a critical role in the amount of oxygen dissolved in the water. The rat studies indicated that oxygenated water reduced serum uric acid levels and their rate of increase and enhanced uric acid metabolism. A significant improvement in uric acid metabolism and rate of increase in serum uric acid concentration was observed in hyperuricemic rats administered oxygenated water compared to that in rats administered regular water. High oxygen concentrations enhanced the rate of oxygen absorption, leading to increased glycolysis and mitochondrial protein synthesis. Therefore, oxygenated water is a potential adjuvant therapy or health food for treatment of hyperuricemia.

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Section: Introductionmentioning

confidence: 77%

Effects of Highly Oxygenated Water in a Hyperuricemia Rat Model

Fang

Tsai

Shyong

et al. 2020

Journal of Healthcare Engineering

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“…After all, it is not just in chickens that the positive effects of oxygenated water have been reported. Handajani et al [58] found that drinking such a solution was beneficial for diabetes mellitus, although other reports are sceptical. For example, Gruber et al [59] said that although there were no long-term detrimental effects on the liver, blood or immune system in humans, the presence of radicals in the blood was increased, albeit transiently.…”

Section: Oxyhydrogenmentioning

confidence: 99%

An Interplay of Gases: Oxygen and Hydrogen in Biological Systems

Russell,

May,

Hancock

2024

Oxygen

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Produced by photosynthesis, oxygen (O2) is a fundamentally important gas in biological systems, playing roles as a terminal electron receptor in respiration and in host defence through the creation of reactive oxygen species (ROS). Hydrogen (H2) plays a role in metabolism for some organisms, such as at thermal vents and in the gut environment, but has a role in controlling growth and development, and in disease states, both in plants and animals. It has been suggested as a medical therapy and for enhancing agriculture. However, the exact mode of action of H2 in biological systems is not fully established. Furthermore, there is an interrelationship between O2 and H2 in organisms. These gases may influence each other’s presence in solution, and may both interact with the same cellular components, such as haem prosthetic groups. It has also been suggested that H2 may affect the structures of some proteins, such as globins, with possible effects on O2 movement in organisms. Lastly, therapies may be based on supplying O2 and H2 together, such as with oxyhydrogen. Therefore, the relationship regarding how biological systems perceive and respond to both O2 and H2, and the interrelationship seen are worth considering, and will be discussed here.

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“…Namun berdasarkan penelitian Speit et al (2002), konsumsi minuman beroksigen tidak menimbulkan efek genotoksik berdasarkan uji in vivo dan in vitro. Penelitian dilakukan oleh Handajani et al (2009) menunjukkan kadar MDA pada subjek diabetes mellitus dengan status gizi normal yang diberikan minuman beroksigen selama 45 hari cenderung menurun. Studi yang dilakukan oleh Gruber et al (2005) menunjukkan konsumsi air beroksigen dalam jangka panjang tidak membahayakan hati, sel darah, dan sistem imun.…”

Section: Pendahuluan1unclassified

Pengaruh Konsumsi Minuman Beroksigen Terhadap Inflamasi Dan Kapasitas Antioksidan Penderita Penyakit-Paru-Obstruktif-Kronik (Ppok)

Rungkat-Zakaria¹,

Azni²,

Syamsir³

et al. 2014

jtip

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Chronic Obstructive Pulmonary Disease (COPD) is one of the leading cause of death in the world that represents an important public health problem. Oxygenated water is water added with high concentration of oxygen such that the oxygen concentration is higher than normal water. The objective of this study was to assess the influence of oxygenated water consumption on the alteration of proinflammatory cytokines (TNF-α, IL1-β, and IL6) and antioxidant capacity of COPD patients. Sixteen COPD patients were allowed to drink 385 mL oxygenated water two times a day for 21 days. The alteration of proinflammatory cytokines and antioxidant capacity are measured by comparing plasma concentration before and after intervention. The results suggest that oxygenated water consumption significantly reduce proinflammatory cytokines plasma and IL6) at 5% significance level with 81.25% of respondents having lower TNF-α, 75% of respondents with lower IL-1β, and 62.25% of respondents having lower the IL-6 in plasma concentration after 21 days intervention. There were 43.75% of respondents with decreased antioxidant capacity concentration. However, it was not significant at the 5% level significance. Decrease in antioxidant capacity was probably a resulted from poordiet and drugs consumption during the intervention period.

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The effect of oxygenated water in Diabetes Mellitus

Cited by 7 publications

References 5 publications

Effects of Highly Oxygenated Water in a Hyperuricemia Rat Model

Effects of Highly Oxygenated Water in a Hyperuricemia Rat Model

An Interplay of Gases: Oxygen and Hydrogen in Biological Systems

Pengaruh Konsumsi Minuman Beroksigen Terhadap Inflamasi Dan Kapasitas Antioksidan Penderita Penyakit-Paru-Obstruktif-Kronik (Ppok)

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