The effect of ozone on human cellular and humoral immunity: Characterization of T and B lymphocytes by rosette formation

Savino, Anthony K.; Peterson, M.L.; House, Dennis E.; Turner, Alvis G.; Jeffries, Harvey E.; Baker, Robin

doi:10.1016/0013-9351(78)90079-8

Cited by 13 publications

(3 citation statements)

References 10 publications

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“…Exposure of subjects to 0.4 ppm 03 for 4 hr impaired the ability of B-cells to form rosettes with human erythrocytes, whereas the ability of T-cells to form rosettes with sheep erythrocytes was unaffected (19). Another study examined the effects of a single 2-hr exposure to 0.6 ppm 03 on the mitogenic response of peripheral lymphocytes following stimulation with PHA, ConA, pokeweed mitogen (PWM), and Candida albicans.…”

Section: Environmental Health Perspectivesmentioning

confidence: 99%

The Effects of Ozone on Immune Function

Jakab¹,

Spannhake²,

Canning³

et al. 1995

Environmental Health Perspectives

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A review of the literature reveals that ozone (03) exposure can either suppress or enhance immune responsiveness. These disparate effects elicited by 0 exposure depend, in large part, on the experimental design used, the immune parameters examined as well as the animal species studied.Despite the apparent contradictions, a general pattern of response to 03 exposure can be recognized. Most studies indicate that continuous 03 exposure leads to an early (days 0-3) impairment of immune responsiveness followed, with continued exposures, by a form of adaptation to 03 that results in a re-establishment of the immune response. The effects of 03 exposure on the response to antigenic stimulation also depend on the time at which 03 exposure occurred. Whereas 03 exposure prior to immunization is without effect on the response to antigen, 03 exposure subsequent to immunization suppresses the response to antigen. Although most studies have focused on immune responses in the lung, numerous investigators have provided functional and anatomical evidence to support the hypothesis that 03 exposure can have profound effects on systemic immunity. -Environ Health Perspect 1 03(Suppl 2): 77-89 (1995)

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Section: Environmental Health Perspectivesmentioning

confidence: 99%

The Effects of Ozone on Immune Function

Jakab¹,

Spannhake²,

Canning³

et al. 1995

Environmental Health Perspectives

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show abstract

“…Several studies have also investigated the effect of 0 exposure on human peripheral blood lymphocytes. Exposure of subjects to 0.4 ppm 03 for 4 hr impaired the ability of B-cells to form rosettes with human erythrocytes, whereas the ability of T-cells to form rosettes with sheep erythrocytes was unaffected (19). Another study examined the effects of a single 2-hr exposure to 0.6 ppm 03 on the mitogenic response of peripheral lymphocytes following stimulation with PHA, ConA, pokeweed mitogen (PWM), and Candida albicans.…”

Section: Effect Of Ozone On Immune Function In the Absence Of Antigenmentioning

confidence: 99%

The effects of ozone on immune function.

Jakab

Spannhake

Canning

et al. 1995

Environ Health Perspect

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A review of the literature reveals that ozone (O3) exposure can either suppress or enhance immune responsiveness. These disparate effects elicited by O3 exposure depend, in large part, on the experimental design used, the immune parameters examined as well as the animal species studied. Despite the apparent contradictions, a general pattern of response to O3 exposure can be recognized. Most studies indicate that continuous O3 exposure leads to an early (days 0-3) impairment of immune responsiveness followed, with continued exposures, by a form of adaptation to O3 that results in a re-establishment of the immune response. The effects of O3 exposure on the response to antigenic stimulation also depend on the time at which O3 exposure occurred. Whereas O3 exposure prior to immunization is without effect on the response to antigen, O3 exposure subsequent to immunization suppresses the response to antigen. Although most studies have focused on immune responses in the lung, numerous investigators have provided functional and anatomical evidence to support the hypothesis that O3 exposure can have profound effects on systemic immunity.

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“…0, also affects lymphocyte function in both the lung (Burleson et al, 1989) and mediastinal lymph nodes (Dziedzic and White, 1986). In addition to these effects on pulmonary immune responses, 0, has been shown to sup ress the response of human peripheral blood leukocytes (PBL) to T-cel P mitogens following both in vivo and in vitro exposure (Peterson et al, 1978b(Peterson et al, , 1981; Orlando et al, 1988; Becker et al, 1989) and to suppress phagocytic and bactericidal activity of polymorphonuclear leukocytes (Peterson et al, 1978a) and B-cell rosette formation (Savino et al, 1978) in PBL from 0,-exposed volunteers. In mice the response of spleen cells to T-cell mitogens was also suppressed (Aranyi et al, 1983) following 0, exposure, as were the antibody and delayed-type hypersensitivity responses to sheep red blood cells (Fujimaki et al, 1984(Fujimaki et al, , 1987.…”

Section: Introductionmentioning

confidence: 96%

Acute, Subchronic, and Chronic Exposure to a Simulated Urban Profile of Ozone: Effects on Extrapulmonary Natural Killer Cell Activity and Lymphocyte Mitogenic Responses

Selgrade

Daniels

Grose

1990

Inhalation Toxicology

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Rats were exposed for 7, 3, 73, 52, or 78 wk to air or a simulated urban profile of 0, designed to mimic diurnal exposure patterns frequently seen in worst-case summer environments. Daily exposures consisted of a background level of 0.06 ppm for a period of 73 h, a broad exposure spike rising from 0.06 to 0.25 ppm and returning to 0.06 ppm over 9 h, and a 2 h downtime. Integration of the spike portion of the exposure pattern was equivalent to a 9-h square-wave exposure pattern of 0.79 ppm. Rats were exposed to this profile 5 days/wk; weekend exposures were to background levels onlK Spleens were removed and blood was drawn at the end of the exposure periods. Spleen cells were assessed for natural killer cell (NKC) activity and responses to T-cell mitogens, phytohemagglutinin and concanavalin A, and the B-cell mitogen, Salmonella typhimurium glycoprotein. Peripheral blood leukocytes (PSU were also assessed for responses to T-cell mitogens. Sections from spleen, femur (including bone marrow), thymus, and mandibular, peribronchial, and mediastinal lymph nodeswere taken from similarly treated rats and examined histopathologically 0, exposure had no effect on NKC activity, nor were any Orrelated changes in mitogen responses or histopathology noted. Mitogen responses, but not NKC activity, were significantly depressed, presumably as a result of age, following the 52-and 78-wk exposures. PBL responses to mitogens were also lower following the 7 I w k compared to 7-and 3-wk exposures. Effects of a single 3-h exposure to 7 ppm 0, on spleen-cell responses to the same mitogens were also determined 0, 24'48, and 72 h after exposure; there were also no effects due to this acute exposure.The authors wish to thank Drs. Judith A. Graham and Frederick j. Miller, whose effort made this chronic study possible and who were largely responsible for establishing the exposure regimen. They also wish to thank Diane M. Starnes for technical assistance and Donald Doerfler for statistical analysis. Inhalation Toxicology Downloaded from informahealthcare.com by TIB/UB Hannover on 01/03/15 For personal use only. Inhalation Toxicology Downloaded from informahealthcare.com by TIB/UB Hannover on 01/03/15 For personal use only. Leukocyte Bio. 38:531-540. Inhalation Toxicology Downloaded from informahealthcare.com by TIB/UB Hannover on 01/03/15 For personal use only.

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The effect of ozone on human cellular and humoral immunity: Characterization of T and B lymphocytes by rosette formation

Cited by 13 publications

References 10 publications

The Effects of Ozone on Immune Function

The Effects of Ozone on Immune Function

The effects of ozone on immune function.

Acute, Subchronic, and Chronic Exposure to a Simulated Urban Profile of Ozone: Effects on Extrapulmonary Natural Killer Cell Activity and Lymphocyte Mitogenic Responses

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