The effect of palmitic acid on lipoprotein cholesterol levels

Clandinin, Michael T.; Cook, Stephanie; Konard, S D; French, Margaret A

doi:10.1080/096374800111112

Cited by 34 publications

(33 citation statements)

References 38 publications

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“…In addition, much remains to be understood about the health effects of individual fatty acids. For example, while stearic acid does not raise LDL concentrations 37,38 it may be atherogenic via other mechanisms, such as increasing lipoprotein(a) or decreasing high-density lipoprotein 25 . Another limitation is that not all of the components of the DQI (i.e.…”

Section: Discussionmentioning

confidence: 99%

Selected nutritional biomarkers predict diet quality

Neuhouser

Patterson

King

et al. 2003

Public Health Nutr.

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Objective: To examine associations of biomarkers of nutrient intake with overall diet quality. Subjects: A convenience sample of 102 healthy postmenopausal women in Seattle, Washington (USA). Design and method: Participants attended a study centre where they provided fasting blood specimens and completed a 122-item validated food-frequency questionnaire (FFQ). Data from the FFQ were used to calculate Diet Quality Index (DQI) scores and categorise women as having diets of excellent, good, fair or poor quality. The blood specimens were analysed for nine phospholipid fatty acids (as percentage of total) and serum concentrations of vitamin C, a-tocopherol, g-tocopherol, vitamin B 12 , folate and six carotenoids. Multivariate linear regression was used to model associations of the nutrient biomarkers with DQI scores. Results: Compared with women with poor-quality diets, women with excellent diets, as measured by the DQI, had higher plasma concentrations of vitamin C (P for trend ¼ 0.01), a-tocopherol (P for trend ¼ 0.02) and b-cryptoxanthin (P for trend ¼ 0.03). Women with excellent diets also had lower proportions of plasma phospholipid fatty acids of two potentially atherogenic fatty acids: stearic acid (P for trend ¼ 0.01) and behenic acid (P for trend ¼ 0.03). A group of six biomarkers explained a moderate proportion of the total variability in DQI scores (36%). Conclusions: These objective measures of dietary intake support the use of the DQI as a useful tool to measure dietary patterns.

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Section: Discussionmentioning

confidence: 99%

Selected nutritional biomarkers predict diet quality

Neuhouser

Patterson

King

et al. 2003

Public Health Nutr.

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“…For instance, the main SFA in veal was 16:0 that has generally been implicated in increasing total and low density lipoprotein cholesterol concentrations. However, it was shown that this effect was reversed in the presence of an adequate supply of 18:2n-6 in the human diet (Clandinin, Cook, Konrad, & French, 2000). Furthermore, 18:0 that comprises about one third of the SFAs in calf meats (33 % in Tudanca and 36 % in Limousin), is a FA known to lower total cholesterol and show a favorable total : HDL cholesterol ratio (Mensink et al, 2003).…”

Section: Composition Of Sfas Needs To Be Considered As Well As Their mentioning

confidence: 99%

Breed effect on quality veal production in mountain areas: emphasis on meat fatty acid composition

et al. 2012

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“…Recent data have, however, shown that: each SFA has its own characteristics, so they should not be considered collectively (Hu et al 1999); the atherogenicity of a given SFA might depend on the intake of another fatty acid (e.g. linoleic acid (LIA); Clandinin et al 2000); certain SFA might increase the synthesis of very-long-chain derivate PUFA (Jan et al 2004).…”

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confidence: 99%

Variations in daily intakes of myristic and α-linolenic acids in sn-2 position modify lipid profile and red blood cell membrane fluidity

Dabadie

Motta²,

Peuchant

et al. 2006

Br J Nutr

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The present study evaluated the effects of moderate intakes of myristic acid (MA), at 1·2 % and 1·8 % of total energy (TE), associated with a 0·9 % TE intake of a-linolenic acid (ALA) on lipid and fatty acid profiles and red blood cell membrane fluidity. Twenty-nine monks without dyslipidaemia were enrolled in a 1-year nutritional study in which two experimental diets were tested for 3 months each: diet 1, MA 1·2 % and ALA 0·9 %; diet 2, MA 1·8 % and ALA 0·9 %. A control diet (MA 1·2 %, ALA 0·4 %) was given 3 months before diets 1 and 2. Thus, two different levels of MA (1·2 %, 1·8 %) and ALA (0·4 %, 0·9 %) were tested. Intakes of other fatty acids were at recommended levels. Samples were obtained on completion of all three diets. For fluidity analysis, the red blood cells were labelled with 16-doxylstearate and the probe incorporated the membrane where relaxation-correlation time was calculated. Diet 1 was associated with a decrease in total cholesterol, in LDL-cholesterol, in triacylglycerols and in the ratio of total to HDL-cholesterol; ALA and EPA levels were increased in both phospholipids and cholesterol esters. Diet 2 was associated with a decrease in triacylglycerols and in the ratios of total to HDL-cholesterol and of triacylglycerols to HDL-cholesterol, and with an increase in HDL-cholesterol; EPA levels were decreased in phospholipids and cholesterol esters. Red blood cell membrane fluidity was increased in both diets (P,0·0001), but the higher increase was obtained with diet 1, mainly in the oldest subjects. Intakes of myristic acid (1·2 %TE) and ALA (0·9 %TE), both mainly in the sn-2 position, were associated with favourable lipid and n-3 long-chain fatty acid profiles. These beneficial effects coexisted with particularly high membrane fluidity, especially among the oldest subjects. It has been clearly shown by many epidemiological studies that high saturated fatty acid (SFA) consumption has atherogenic effects and promotes CHD (Keys, 1980;Sandker, 1992;Ascherio et al. 1996). These effects may be mediated to a certain extent by fatty acid-induced changes in serum lipid levels, especially of LDL-cholesterol or HDL-cholesterol, oxidative status, haemostasis, blood pressure and membrane fluidity. The results of these studies have been used to make specific dietary recommendations for the prevention and treatment of CHD leading to a change in eating habits (Krauss et al. 2000). Recent data have, however, shown that: each SFA has its own characteristics, so they should not be considered collectively (Hu et al. 1999); the atherogenicity of a given SFA might depend on the intake of another fatty acid (e.g. linoleic acid (LIA); Clandinin et al. 2000); certain SFA might increase the synthesis of very-long-chain derivate PUFA (Jan et al. 2004).No study on myristic acid (MA) to date has been conducted with intakes corresponding to those of real life (Tholstrup et al. 1994;Zock et al. 1994;Mensink et al. 2003). It is widely held that, beyond 4 % of total energy (TE), MA leads to an increase in total and LDL-cho...

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The effect of palmitic acid on lipoprotein cholesterol levels

Cited by 34 publications

References 38 publications

Selected nutritional biomarkers predict diet quality

Selected nutritional biomarkers predict diet quality

Breed effect on quality veal production in mountain areas: emphasis on meat fatty acid composition

Variations in daily intakes of myristic and α-linolenic acids in sn-2 position modify lipid profile and red blood cell membrane fluidity

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