The Effect of Partial Hydrogenation of Dietary Fats, of the Ratio of Polyunsaturated to Saturated Fatty Acids, and of Dietary Cholesterol upon Plasma Lipids in Man *

Erickson, Beth; Coots, Robert H.; Mattson, F.H.; Kligman, Albert M.

doi:10.1172/jci105076

Cited by 126 publications

(14 citation statements)

References 25 publications

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“…Although the mechanism(s) responsible for this effect remains poorly understood, the relationship between various dietary lipids and plasma cholesterol levels in man has been studied in considerable detail (5)(6)(7)(8)(9). From these studies it appears that the magni-tude of the change in plasma cholesterol levels that can be achieved is dependent upon the ratio of polyunsaturated to saturated fatty acids in the diet.…”

Section: Introductionmentioning

confidence: 99%

Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster.

Spady

Dietschy²

1988

J. Clin. Invest.

342

149

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These studies report the effects of dietary cholesterol and triglyceride on rates of receptor-dependent and receptor-independent LDL transport in the liver of the hamster. In animals fed diets enriched with 0.1, 0.25, or 1% cholesterol for 1 mo, receptor-dependent LDL transport in the liver was suppressed by 43, 63, and 77%, respectively, and there were reciprocal changes in plasma LDL-cholesterol concentrations. In addition, dietary triglycerides modified the effect of dietary cholesterol on hepatic LDL transport and plasma LDL concentrations so that at each level of cholesterol intake, polyunsaturated triglycerides diminished and saturated triglycerides accentuated the effect of dietary cholesterol. When animals were raised from weaning on diets containing small amounts of cholesterol, the decline in receptor-dependent LDL transport was nearly abolished by the addition of polyunsaturated or monounsaturated triglycerides, but was markedly augmented by the addition of saturated lipids. When animals raised on diets containing cholesterol and saturated triglycerides were returned to the low cholesterol, low triglyceride control diet, hepatic receptor-dependent LDL transport and plasma LDLcholesterol concentrations returned essentially to normal within 2 wk. Neither receptor-independent LDL transport nor the receptor-dependent uptake of asialofetuin was significantly altered by dietary cholesterol or triglyceride suggesting that the effect of these lipids on hepatic LDL receptor activity was specific and not due to a generalized alteration in the physiochemical properties of hepatic membranes. These studies demonstrate the important role of saturated triglycerides in augmenting the effect of cholesterol in suppressing hepatic LDL receptor activity and elevating LDL-cholesterol levels.

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Section: Introductionmentioning

confidence: 99%

Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster.

Spady

Dietschy²

1988

J. Clin. Invest.

342

149

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show abstract

“…Heckers and Melcher (12) reported that trans fatty acids have a greater plasma cholesterol-raising effect than oleic acid in the presence of dietary cholesterol. Erickson et al (13) indicated that there was no increase in serum cholesterol from feeding trans fatty acid-rich diets with or without cholesterol. In our previous report (14) and in our present swine experiment, dietary trans fatty acid had no significant effect on plasma cholesterol levels.…”

mentioning

confidence: 99%

Comparative study of the atherogenecity of dietary trans, saturated and unsaturated fatty acids on swine coronary arteries.

Toda

Yamamoto

et al. 1985

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…While there is apparently general agreement that dietary polyunsaturated fatty acids lower the serum lipid levels in contrast to saturated fatty acids (28), several investigations have failed to confirm this general view under certain experimental conditions (20,31,32 (21).…”

mentioning

confidence: 99%

Cholesterol balance and fecal neutral steroid and bile acid excretion in normal men fed dietary fats of different fatty acid composition

Connor¹,

Witiak²,

Stone³

et al. 1969

J. Clin. Invest.

275

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A B S T R A C T Six normal men were fed formula diets containing either highly saturated fat (cocoa butter, iodine value 32) or polyunsaturated fat (corn oil, iodine value 125). The sterol balance technique was used to compare the changes in serum cholesterol concentration with the excretion of fecal steroids. The method used for the analysis of fecal steroids was chemical, with a final identification and quantification by gas-liquid chromatography. It was confirmed that the chemical method for fecal steroid analysis was accurate and reproducible.The three dietary periods were each 3 wk in length. In sequence, cocoa butter (period I), corn oil, and cocoa butter (period III) were fed at 40% of the total calories. All diets were cholesterol free, contained similar amounts of plant sterols, and were identical in other nutrients.Corn oil had a hypocholesterolemic effect. Mean serum cholesterol concentrations were 222 mg/100 ml (cocoa butter, period I), 177 during corn oil, and 225 after the return to cocoa butter. Individual fecal steroids were determined from stools pooled for 7 days. Both neutral steroids and bile acids were altered significantly by dietary polyunsaturated fat. The change in bile acid excretion was considerably greater than the change in neutral steroids. Corn oil caused a greater fecal excretion of both deoxycholic and lithocholic acids. The total mean excretion (milligrams per day) of fecal

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The Effect of Partial Hydrogenation of Dietary Fats, of the Ratio of Polyunsaturated to Saturated Fatty Acids, and of Dietary Cholesterol upon Plasma Lipids in Man *

Cited by 126 publications

References 25 publications

Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster.

Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster.

Comparative study of the atherogenecity of dietary trans, saturated and unsaturated fatty acids on swine coronary arteries.

Cholesterol balance and fecal neutral steroid and bile acid excretion in normal men fed dietary fats of different fatty acid composition

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