The effect of passive heating on heat shock protein 70 and interleukin-6: A possible treatment tool for metabolic diseases?

Faulkner, Simon; Jackson, Sarah; Fatania, Ganisha; Leicht, Christof A.

doi:10.1080/23328940.2017.1288688

Cited by 60 publications

(51 citation statements)

References 63 publications

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“…; Faulkner et al . ), which was also observed in the present study (on average, an ∼2‐fold increase). [IL‐6] was also increased following exposure to sera collected following the first hot water immersion session (Acute HT).…”

Section: Discussionsupporting

confidence: 91%

“…For example, IL-6 is elevated acutely following exercise and is thought to mediate adaptation to exercise training (Pedersen & Fischer, 2007). Similarly, IL-6 has been shown to be elevated following acute hot water immersion (Leicht et al 2015;Faulkner et al 2017), which was also observed in the present study (on average, an ß2-fold increase). was also increased following exposure to sera collected following the first hot water immersion session (Acute HT).…”

Section: Basal Effects Of Heat Pretreatment and Serum Exposuresupporting

confidence: 85%

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Passive heat therapy protects against endothelial cell hypoxia‐reoxygenation via effects of elevations in temperature and circulating factors

Brunt

Wiedenfeld-Needham

Comrada

et al. 2018

The Journal of Physiology

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Repeated exposure to passive heat stress ('heat therapy') has widespread physiological benefits, including cellular protection against novel stressors. Increased heat shock protein (HSP) expression and upregulation of circulating factors may impart this protection. We tested the isolated abilities of mild heat pretreatment and serum from human subjects (n = 10) who had undergone 8 weeks of heat therapy to protect against cellular stress following hypoxia-reoxygenation (H/R), a model of ischaemic cardiovascular events. Cultured human umbilical vein endothelial cells were incubated for 24 h at 37°C (control), 39°C (heat pretreatment) or 37°C with 10% serum collected before and after 8 weeks of passive heat therapy (four to five times per week to increase rectal temperature to ≥ 38.5°C for 60 min). Cells were then collected before and after incubation at 1% O for 16 h (hypoxia; 37°C), followed by 20% O for 4 h (reoxygenation; 37°C) and assessed for markers of cell stress. In control cells, H/R increased nuclear NF-κB p65 protein (i.e. activation) by 106 ± 38%, increased IL-6 release by 37 ± 8% and increased superoxide production by 272 ± 45%. Both heat pretreatment and exposure to heat therapy serum prevented H/R-induced NF-κB activation and attenuated superoxide production; by contrast, only exposure to serum attenuated IL-6 release. H/R also decreased cytoplasmic haemeoxygenase-1 (HO-1) protein (known to suppress NF-κB), in control cells (-25 ± 8%), whereas HO-1 protein increased following H/R in cells pretreated with heat or serum-exposed, providing a possible mechanism of protection against H/R. These data indicate heat therapy is capable of imparting resistance against inflammatory and oxidative stress via direct heat and humoral factors.

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Section: Discussionsupporting

confidence: 91%

Section: Basal Effects Of Heat Pretreatment and Serum Exposuresupporting

confidence: 85%

Passive heat therapy protects against endothelial cell hypoxia‐reoxygenation via effects of elevations in temperature and circulating factors

Brunt

Wiedenfeld-Needham

Comrada

et al. 2018

The Journal of Physiology

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“…(7,19,20) The effects of other types of passive heat therapy such as Waon therapy, infrared-ray saunas, warm water immersion, and Turkish baths on inflammation and oxidative stress have been reported in several studies. (21)(22)(23)(24)(25) A number of studies have also suggested that exposure to Finnish sauna may be associated with alteration in concentrations of essential markers of inflammation and oxidative stress. (26)(27)(28)(29) However, these previous findings were however based on short-term effects of sauna exposure or cross-sectional associations.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal associations of sauna bathing with inflammation and oxidative stress: the KIHD prospective cohort study

Kunutsor

Laukkanen

2018

Annals of Medicine

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Observational evidence supports the hypothesis that reduction in inflammation may be one of the pathways linking frequent sauna bathing with decreased risk of acute and chronic disease conditions. KEY MESSAGES Cross-sectional evidence or short-term studies suggest Finnish sauna bathing may exert its beneficial health effects via reduction in inflammation and oxidative stress; however, the long-term effects of sauna bathing on these outcomes are uncertain. In this population-based prospective cohort study, frequent sauna sessions significantly decreased levels of inflammatory markers at baseline and 11-year follow-up; but had no effect on oxidative stress. The health benefits of sauna bathing may in part be mediated via reduced systemic inflammation.

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“…In human whole-body passive heating models, such as hot water immersion of >60 min whereby core body temperature is increased, higher extracellular HSP70 concentration (Faulkner et al, 2017), and intracellular HSP70 changes (Oehler et al, 2001), have been reported. The beneficial response once again is not unanimous, with others reporting chronic change (following 2 weeks of repeated therapy) in intracellular HSP70 after 45-60 min of passive heat therapy (Hoekstra et al, 2018).…”

Section: Chronic Effects Of Body Warming On Heat Shock Proteinsmentioning

confidence: 99%

“…Several mechanistic pathways may underpin these adaptations, including improved cellular respiration , circulating factors (Brunt et al, 2019), and vascular shear stress (Tinken et al, 2009;Thomas et al, 2016). The upregulation of heat shock proteins (HSPs) as a result of acute and/or chronic (repeated) exposure to passive heating is also an adaptive outcome, which may provide a specific mechanistic pathway for improving health and function within the body (Faulkner et al, 2017;Brunt et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Could Heat Therapy Be an Effective Treatment for Alzheimer’s and Parkinson’s Diseases? A Narrative Review

et al. 2020

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Neurodegenerative diseases involve the progressive deterioration of structures within the central nervous system responsible for motor control, cognition, and autonomic function. Alzheimer's disease and Parkinson's disease are among the most common neurodegenerative disease and have an increasing prevalence over the age of 50. Central in the pathophysiology of these neurodegenerative diseases is the loss of protein homeostasis, resulting in misfolding and aggregation of damaged proteins. An element of the protein homeostasis network that prevents the dysregulation associated with neurodegeneration is the role of molecular chaperones. Heat shock proteins (HSPs) are chaperones that regulate the aggregation and disaggregation of proteins in intracellular and extracellular spaces, and evidence supports their protective effect against protein aggregation common to neurodegenerative diseases. Consequently, upregulation of HSPs, such as HSP70, may be a target for therapeutic intervention for protection against neurodegeneration. A novel therapeutic intervention to increase the expression of HSP may be found in heat therapy and/or heat acclimation. In healthy populations, these interventions have been shown to increase HSP expression. Elevated HSP may have central therapeutic effects, preventing or reducing the toxicity of protein aggregation, and/or peripherally by enhancing neuromuscular function. Broader physiological responses to heat therapy have also been identified and include improvements in muscle function, cerebral blood flow, and markers of metabolic health. These outcomes may also have a significant benefit for people with neurodegenerative disease. While there is limited research into body warming in patient populations, regular passive heating (sauna bathing) has been associated with a reduced risk of developing neurodegenerative disease. Therefore, the emerging evidence is compelling and warrants further investigation of the potential benefits of heat acclimation and passive heat therapy for sufferers of neurodegenerative diseases.

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The effect of passive heating on heat shock protein 70 and interleukin-6: A possible treatment tool for metabolic diseases?

Cited by 60 publications

References 63 publications

Passive heat therapy protects against endothelial cell hypoxia‐reoxygenation via effects of elevations in temperature and circulating factors

Passive heat therapy protects against endothelial cell hypoxia‐reoxygenation via effects of elevations in temperature and circulating factors

Longitudinal associations of sauna bathing with inflammation and oxidative stress: the KIHD prospective cohort study

Could Heat Therapy Be an Effective Treatment for Alzheimer’s and Parkinson’s Diseases? A Narrative Review

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