The Effect of Paternal Age on Relapse in First-Episode Schizophrenia

Abstract

Advanced paternal age is found to be modestly but significantly related to more relapses, and such an effect is the strongest at a cut-off of paternal age of 40 years or older. The effect is less likely to be mediated through less effective parental supervision or nonadherence to medication. Other possible biological mechanisms need further explorations.

The predictive power of expressed emotion and its components in relapse of schizophrenia: a meta-analysis and meta-regression

“…Many studies have reported demographic and clinical related risk factors of relapses in patients with schizophrenia. These include medication non-adherence (Alvarez-Jimenez et al, 2012), smoking (Hui et al, 2013), older paternal age (Hui et al, 2015), and cognitive functions such as visual working memory (Hui et al, 2016). Despite medication, non-adherence has been found to be the most significant clinical predictors of relapse (Caseiro et al, 2012), about 50% of patients relapsed while having good adherence to medication (Linszen et al, 1997).…”

Investigating factors associated with the number of rehospitalizations among patients with schizophrenia disorder using penalized count regression models

“…However, in the study by Avcı, the male gender was significantly associated with a greater number of hospitalization [ 27 ]. Apart from that, in the studies of Kal et al [ 28 ] and Hui et al [ 29 ], the female gender was considered as a risk factor for relapse. This is because men and women with schizophrenia may be different in terms of age at onset, premorbid functioning, symptoms level, and outcomes [ 30 ].…”

“…Non-adherence to treatment is also one of the most important issues related to the number of rehospitalizations of schizophrenia disorder. The results of the study of Wu et al [ 39 ] and several other studies including studies of Kal et al [ 28 ] and Hui et al [ 29 ] showed that drug non-compliance is significantly associated with an increased risk of relapse of this disease. Having said that in the studies of San et al and Suzuki et al, there was no significant relationship between drug adherence and disease recurrence [ 31 , 40 ] similar to our study.…”

Identifying and Assessing Barriers to Optimal Outcomes for Psychosis: An Important Research Focus

“…A cornerstone to this end is sustained remission, which includes control of relapses and hospitalizations. Four papers [1][2][3][4] in this edition of The Canadian Journal of Psychiatry contribute to what is imperative: to identify and to assess barriers to optimal outcomes.…”

“…In furthering the examination of determinants of outcomes in early phase psychosis, Dr Christy L M Hui et al 2 determinants as they relate to relapse risk in the first year of illness. They report on a sample out of Hong Kong that advanced paternal age modestly but significantly increased the risk of relapse, and importantly, this finding was independent of factors such as medication adherence, family history, duration of untreated psychosis, and maternal age.…”