In the present work, the magnetoresistance behavior of (TlF)x-substituted (Cu0.5,Tl0.5)Ba2Ca2Cu3O10−δ superconducting samples, with x = 0.0, 0.1, 0.2, 0.3 and 0.4, was investigated. According to the thermally activated flux creep (TAFC) model, the flux pinning energies U(H, T) were calculated from the resistivity temperature (ρ–T) curves at applied DC magnetic fields ranging from 0.29 to 4.44 kOe. The results indicated that flux pinning energy was increased with increasing the F-substituting up to x = 0.1 and then decreased with increasing the applied field up to 4.44 kOe. Moreover, significant resistive broadening (ΔT) was observed with increasing the values of the applied magnetic fields. Furthermore, the (TlF)x substitution, boosting the transport critical current density Jc(0) and irreversibility magnetic field Hirr(0) up to x = 0.1 and then decreasing for x > 0.1 at various applied magnetic fields, demonstrates strong flux pinning for x = 0.1.