The Effect of Pegagan Gel (Centella Asiatica (L.) Urban) on Wound Healing Processes in Mice (Mus Musculus) in Vivo

Poernomo, Hendri; DS, Setiawan

doi:10.30659/odj.9.0.137-146

Cited by 1 publication

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“…9 Those compounds act as a central nervous system depressor through its interaction with the gamma-aminobutyricacid receptor (GABA) as in the diazepam molecules. 10 A series of animal trials are needed on this alternative agent for pharmacological evaluation and initial screening of dose determination before testing in humans. Mice have organ components that can represent other mammals, especially humans.…”

Section: Introductionmentioning

confidence: 99%

Anxiolytic effect of aqueous extract of moringa oleifera in balb/c mice

Pratiwi,

Kuswandari,

Utomo

2023

Odonto: Dental Journal

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Background: Anxiety control is required to achieve successful dental treatment especially in children. Dental anxiety is exaggerated fear or worry associated with dental treatment and it is followed with a sense of losing control. Moringa oleifera has been claimed as a potential plant to treat anxiety. A large amount of flavonoid in Moringa oleifera leaves is known to have anxiolytic effect due to their interaction with gamma-aminobutyricacid (GABA) receptors like benzodiazepine molecule. The aim of this study was to determine the anxiolytic effect of aqueous extract of Moringa oleifera (AEMO) leaves in balb/c mice. Method: Subject of this study was 25 mice divided into 5 groups. Diazepam as a positive control (K+), CMC-Na 0.5% as a negative control (K-), aqueous extract of M. oleifera leaves 375 mg/kgBW (P1), 500 mg/kgBW (P2), and 625 mg/kgBW (P3). Tests were conducted using Elevated Plus Maze. Before and after data were analyzed with paired T-test, differences of anxiety score between groups was analyzed with One-way ANOVA. Result: Group P2 and P3 significantly reduce anxiety in mice (p <0.05). The anxiolytic effect showed by group P2, P3 and K(+) were significantly different (p <0.05) compared to group K(-). Conclusion: Aqueous extract of Moringa oleifera leaves produced its anxiolytic effect at 500mg/kgBW and 625mg/kgBW peroral.

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Section: Introductionmentioning

confidence: 99%