The effect of pendant group structure on the thermoresponsive properties of N-substituted polyesters

Abstract

Structure–property correlation studies of a diverse set of biodegradable thermoresponsive polyesters provides a rationale for the design of thermoresponsive polyesters with desired cloud points.

Precise Synthesis and Thermoresponsive Property of Poly(ethyl glycidyl ether) and Its Block and Statistic Copolymers with Poly(glycidol)

“…The clear-turbid phase transition occurred before and after cloud point temperature (T cp ) [19][20][21][22][23]. The polymer hydration is thus wrapped by water molecules and dissolves when the temperature is lower than T cp .…”

Precision synthesis for well-defined linear and/or architecturally controlled thermoresponsive poly(N-substituted acrylamide)s

“…35 The inherent oxymethylene moieties of these polymers exhibit the properties like abovementioned amide linkages. N-Succinamide polyesters (HESA polyesters) 36 have been developed as biodegradable thermoresponsive polymers. Another promising strategy to introduce thermoresponsive property into polymers is to modify the side chains of the polymer with multiple oligoethylene glycol (OEG) chains.…”

Tropoelastin-Inspired, Non-Ionic, Self-Coacervating Polyesters as Strong Underwater Adhesives

“…We base this study on our previously reported serendipitous discovery that a library of thermoresponsive polyesters designed in our lab show 'tropoelastin-like' coacervation behavior. [18][19][20] Tropoelastin, the soluble precursor to elastin, shows lower critical solution temperature (LCST) in aqueous medium, and above LCST, the protein solution segregates to both dilute and proteinrich dense phases. [21] Similarly, our polyester library also shows hydrophobically-driven, single component coacervation.…”

“…[21] Similarly, our polyester library also shows hydrophobically-driven, single component coacervation. Their non-ionic, bioabsorbable, [19] cell-compatible, [20] and modular nature, allows incorporation of various functional groups [18] and hence this platform provides significant advantages over any other reported coacervates to date. In this study, we report an extension of the above polyesters, wherein incorporation of appropriate functional groups provides a new class of non-ionic, self-coacervating polyesters that demonstrate rapid, watertolerant crosslinking, resulting in strong underwater adhesion.…”

“…In contrast to the complex coacervates, these 'charge-free' coacervates are potential candidates as tissue adhesives and sealants, adhesives for sensor attachment to wet skin, and as sprayable adhesives. Their potential use in the clinic arises from their enhanced stability to changes in external conditions, cytocompatibility, [20] biodegradability [19] and modular nature in incorporating various functional groups [18] and crosslinkers.…”