The effect of pentoxifylline on the flow properties of human blood

Ehrly, A. M.

doi:10.1185/03007997809110195

Cited by 53 publications

(12 citation statements)

References 6 publications

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“…On the other hand, elevation of the cAMP leads to cytosolic Ca 2+ decrease via inhibition of its entry into cells [43]. The Ca 2+ concentration increase was removed, if it was added to incubation medium preliminary phosphodiesterase inhibitor or a permeable cAMP analog [44][45][46]. It was found that all four PDE inhibitors -IBMX, vinpocetine, rolipram, pentoxifylline -decreased RBCA significantly and on the other hand they increased red cell deformability.…”

Section: Discussionmentioning

confidence: 99%

Extra- and intracellular signaling pathways under red blood cell aggregation and deformability changes

Muravyov

Тихомирова²,

Maimistova³

et al. 2009

Clinical Hemorheology and Microcirculation

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Exposure of red blood cells (RBCs) to catecholamines (epinephrine, phenylephrine, an agonist of α 1 -adrenergic receptors, clonidine, an agonist of α 2 -adrenergic receptors and isoproterenol, an agonist of β-adrenergic receptors) led to change in the RBC microrheological properties. When forskolin (10 µM), an AC stimulator was added to RBC suspension, the RBC deformability (RBCD) was increased by 17% (p < 0.05). Somewhat more significant deformability rise appeared after RBC incubation with dB-AMP (by 27%; p < 0.01). Red blood cell aggregation (RBCA) was significantly decreased under these conditions (p < 0.01). All drugs having PDE activity increased red cell deformability similarly. Some more changes of deformability was found after RBC incubation with pentoxifylline -25% (p < 0.05) and IBMX incubation was accompanied only by 15% rise of RBC deformability. The drugs with PDE inhibitory activity reduced red cell aggregation. The most significant RBCA reduction effect was found under cell incubation with pentoxifylline and inhibitor PDE 1 -vinpocetine. On the whole RBCA reduction averaged 36% (p < 0.05) under RBCs incubation with PDE inhibitors. The rise of Ca 2+ influx, stimulated by A23187, was accompanied by an increase of RBCA, whereas red cell deformability was changed insignificantly. At the same time Ca 2+ entry blocking into the red cells by verapamil or its chelating in medium by EGTA led to significant RBCA decrease and deformability rise (p < 0.05).On the whole the total data clearly show that the red cell aggregation and deformation changes were connected with an activation of the different intracellular signaling pathways. It seems reasonable to suppose that RBCA decrease was mainly associated with an activation of the adenylyl-cyclase-cAMP system, while the red cell deformability was closely associated with Ca 2+ control mechanisms.

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Section: Discussionmentioning

confidence: 99%

Extra- and intracellular signaling pathways under red blood cell aggregation and deformability changes

Muravyov

Тихомирова²,

Maimistova³

et al. 2009

Clinical Hemorheology and Microcirculation

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“…Marked alterations of the main haemorheologic parameters were recorded. On the basis of these findings we undertook this study with the following aims: 1) to investigate the rheologic properties of blood in a group of mountaineers after a HA expedition and 2) subordinately, to assess the possible effects on the same properties of a drug known to influence haemorheology (Pentoxifylline, Px, Trental~ 400) .4 4 Team, Expedition and Treatment We have investigated 14 mountaineers, members of the Italian expedition &dquo;To Annapurna II&dquo; (Himalaya of Nepal, 1981), immediately before their departure and after their return 61 days later. All subjects had given their informed consent to the study.…”

Section: Introductionmentioning

confidence: 99%

Changes in the Rheologic Properties of Blood after a High Altitude Expedition

Palareti¹,

Coccheri²,

Poggi³

et al. 1984

Angiology

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The changes in blood rheologic properties induced by exposure to high altitude plus heavy and prolonged physical strain were investigated in 14 climbers of an Italian expedition to Himalaya (maximum altitude reached m 7350). In blood samples collected immediately after return, alterations of some haemorheologic parameters were observed in comparison with baseline values, and namely an increase in relative blood viscosity, fibrinogen and erythrocyte filtration time along with a fall in platelet count. Treatment with a drug acting on the red cell deformability (Pentoxifylline) appeared to prevent the changes in blood viscosity and erythrocyte filterability. In the 9 climbers whom we were able to re-examine after three months, all altered parameters were found to be restored to baseline values. These results contribute to the knowledge of the pathogenesis of high altitude disease and stress the significance of altered haemorheology as one of the mechanisms possibly involved in the vascular events observed in this condition.

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“…It is currently used in peripheral vascular disease. Although there is great enthusiasm for its potential use in acute stroke, no randomized trials have yet been done [9,[91][92][93].…”

Section: Therapymentioning

confidence: 99%

Analytic Review: Ischemic Cerebrovascular Disease: Diagnosis and Management

Tegeler

Sherman

1986

J Intensive Care Med

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disease: diagnosis and management J Intensive Care Med 1986;1:184-196. Ischemic stroke is the most common cause of neurologic morbidity and mortality. The proper management of a stroke patient is dictated by the underlying pathophysiology. An ischemic stroke may occur as a result of restricted flow or thrombosis from atherosclerosis, artery-to-artery embolization, cardiac-to-brain embolization, or disorders of coagulation, to mention a few of the most common causes. Determining the relevant cause of stroke is made more difficult by the coexistence of many possible factors such as hypertension, atherosclerosis, and cardiac disease. Nevertheless, judgments are based on the clinical presentation, computed tomographic scans, cerebral angiograms, and results of echocardiography and electrocardiographic monitoring.Therapy of the ischemic stroke patient is aimed primarily at preserving areas of potentially recoverable ischemic brain. This is accomplished by correcting or avoiding circumstances that can promote further impairment of ischemic brain. These include proper management of blood pressure, cardiac function, oxygenation, and fluid balance. The role of anticoagulation, hemodilution therapy, and other proposed forms of therapy is often unclear.

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The effect of pentoxifylline on the flow properties of human blood

Cited by 53 publications

References 6 publications

Extra- and intracellular signaling pathways under red blood cell aggregation and deformability changes

Extra- and intracellular signaling pathways under red blood cell aggregation and deformability changes

Changes in the Rheologic Properties of Blood after a High Altitude Expedition

Analytic Review: Ischemic Cerebrovascular Disease: Diagnosis and Management

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