The Effect of Peppermint (<i>Mentha piperita</i>) Extract on the Severity of Nausea, Vomiting and Anorexia in Patients with Breast Cancer Undergoing Chemotherapy: A Randomized Controlled Trial

Jafarimanesh, Hadi; Akbari, Mehran; Hoseinian, Rezvan; Zarei, Mahdi; Harorani, Mehdi

doi:10.1177/1534735420967084

Cited by 23 publications

(16 citation statements)

References 30 publications

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“…However, the antitumor activity itself was not affected [ 71 ]. Peppermint ( Mentha piperita ) extract exerted a significant decrease in the man score of severity of nausea, vomiting, and anorexia in breast cancer patients undergoing chemotherapy compared with the control group [ 72 ]. The subcutaneous injection of mistletoe extracts showed a trend toward less neutropenia and improved pain and appetite loss scores in breast cancer patients undergoing surgery and adjuvant chemotherapy with cyclophosphamide, adriamycin, and 5-fluorouracil.…”

Section: Current State Of Clinical Evidence On the Effectiveness Of P...mentioning

confidence: 99%

Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care

et al. 2022

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Breast cancer incidence is actually the highest one among all cancers. Overall breast cancer management is associated with challenges considering risk assessment and predictive diagnostics, targeted prevention of metastatic disease, appropriate treatment options, and cost-effectiveness of approaches applied. Accumulated research evidence indicates promising anti-cancer effects of phytochemicals protecting cells against malignant transformation, inhibiting carcinogenesis and metastatic spread, supporting immune system and increasing effectiveness of conventional anti-cancer therapies, among others. Molecular and sub-/cellular mechanisms are highly complex affecting several pathways considered potent targets for advanced diagnostics and cost-effective treatments. Demonstrated anti-cancer affects, therefore, are clinically relevant for improving individual outcomes and might be applicable to the primary (protection against initial cancer development), secondary (protection against potential metastatic disease development), and tertiary (towards cascading complications) care. However, a detailed data analysis is essential to adapt treatment algorithms to individuals’ and patients’ needs. Consequently, advanced concepts of patient stratification, predictive diagnostics, targeted prevention, and treatments tailored to the individualized patient profile are instrumental for the cost-effective application of natural anti-cancer substances to improve overall breast cancer management benefiting affected individuals and the society at large.

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Section: Current State Of Clinical Evidence On the Effectiveness Of P...mentioning

confidence: 99%

Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care

et al. 2022

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“…Patients in the experimental group were instructed to take 40 drops of peppermint extract mixed in 20 ccs of tap water three times a day, while patients in the control group received 40 drops of distilled water mixed in 20 ccs of tap water three times a day. The severity of nausea, vomiting and anorexia before the intervention and immediately, 24 and 48 hr after the chemotherapy were significantly lower in the intervention group (Jafarimanesh, Akbari, Hoseinian, Zarei, & Harorani, 2020). Considering the effects of spearmint on improving appetite and decreasing CINV, it can be assumed as an excellent additional treatment to standard treatments.…”

Section: Medicinal Herbs In Treating Chemotherapy‐induced Nausea and ...mentioning

confidence: 95%

Medicinal herbs in treating chemotherapy‐induced nausea and vomiting: A review

Rajabalizadeh

Rahbardar

2022

Phytotherapy Research

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Cancer development entangles with mutation and selection for cells that progressively increase capacity for proliferation and metastasis at the cellular level. Surgery, chemotherapy, and radiotherapy are the standard treatments to manage several types of cancer. Chemotherapy is toxic for both normal and cancer cells and can induce unfavorable conditions, such as chemotherapy‐induced nausea and vomiting (CINV), that reduce patients' quality of life. Emesis after chemotherapy is categorized into two classes acute and delayed. Since ancient times, herbal medicines have been used in various cultures to manage stomachache, vomiting, and nausea. In this manuscript, the antiemetic mechanisms of several herbal medicines and their preparations such as Zingiber officinale (5‐HT, NK‐1 receptor and muscarinic antagonist activity), Mentha spicata (5‐HT antagonist activity), Scutellaria baicalensis (antioxidant activity), Persumac (useful in delayed phase through antioxidant, anti‐inflammatory, and anti‐contractile properties) and Rikkunshito (supportive in acute and delayed phase through 5‐HT receptor antagonist activity) have been reviewed to show their potential effects on decreasing CINV and attract scientists attention to formulate more herbal medicine to alleviate CINV in cancer patients. However, it is crucial to say that additional high‐quality investigations are required to firmly verify the clinical effectiveness and safety of each plant/compound.

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“…During pregnancy, the mother's time would be spent more at work therefore mother would feel tired and stressed more quickly due to work (Khorasani et al, 2020). The correlation between psychological factors and the incidence of emesis gravidarum was probably due to the fact that mothers tend to be tired during work, and stress can cause anxiety which can trigger the occurrence of emesis gravidarum (Jafarimanesh et al, 2020) Description of the Intensity of Nausea and Vomiting Before and After Being Administered Peppermint Aromatherapy in the First and Second Trimester Pregnant Women…”

Section: Description Of Respondents Characteristicsmentioning

confidence: 99%

The Effect of Peppermint Aromatherapy on The Incidence of Emesis Gravidarum in The First and Second Trimester Pregnant Women in The Working Area of South Denpasar Public Health Center I, Denpasar City

Agustini¹,

Wulandari²,

Dewi³

2022

J. Sci. n.a

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Emesis gravidarum is a condition that can cause weight loss, impaired body metabolism, malnutrition, weakness, and dehydration felt by the mother. Peppermint aromatherapy administered by inhalation can be a therapy that is able to overcome or eliminate nausea and vomiting in the first and second trimesters of pregnant women. The purpose of this study was to determine the effect before and after administering peppermint aromatherapy on the incidence of Emesis gravidarum in the first and second trimesters of pregnant women. This study was pre-experimental research with one group pretest-posttest design. The sampling technique used was accidental sampling consisting of 20 pregnant women in the first and second trimesters. Data was collected using observation sheets and PUQE-24 questionnaires. The results showed that the average value of nausea and vomiting before being administered peppermint aromatherapy was 8.15 (moderate category) and after being administered peppermint aromatherapy was 4.80 (mild category) with a difference of 3.35 and a significance value of 0.001 (p<0.05), statistically there was a significant difference in the mean of nausea and vomiting after being administered peppermint aromatherapy intervention. This study is expected to provide an overview of the importance of maintaining nutrition during pregnancy so that mothers are avoided chronic energy deficiency and prevent the long-term effects of emesis gravidarum. Mothers are expected to be able to independently implement the use of peppermint aromatherapy as an effort to reduce nausea and vomiting by using easily available ingredients.

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The Effect of Peppermint (Mentha piperita) Extract on the Severity of Nausea, Vomiting and Anorexia in Patients with Breast Cancer Undergoing Chemotherapy: A Randomized Controlled Trial

Cited by 23 publications

References 30 publications

Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care

Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care

Medicinal herbs in treating chemotherapy‐induced nausea and vomiting: A review

The Effect of Peppermint Aromatherapy on The Incidence of Emesis Gravidarum in The First and Second Trimester Pregnant Women in The Working Area of South Denpasar Public Health Center I, Denpasar City

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