Strategic human resources management (SHRM) practices contribute positively to firm performance by creating a qualified, highly motivated and empowered workforce, indirectly affecting the individual's commitment to the organization through job satisfaction. This study aims to determine the mediating role of employee empowerment and perceived organizational support in the effect of SHRM, which has significant effects on both employee participation in decision-making process and organizational structure in manufacturing industry, on job satisfaction and turnover intention of employees. This empirical study was conducted using 165 manufacturing companies in the industrial areas in the region (IAR) of Adana, Gaziantep and Hatay provinces located in the south of Turkey. The data obtained from the surveys were analyzed with SmartPLS using the method of least squares. SHRM positively affected employee empowerment and perceived organizational support, increasing job satisfaction and reducing turnover intention. It is necessary for managers to adopt a SHRM understanding and encourage employees to participate in decision-making processes through employee empowerment practices in order to increase their job satisfaction, which is an important factor on organizational performance, to strengthen their organizational commitment, to raise their perceived organizational support, to fulfill their socio-emotional needs, and to enhance their sense of well-being.