The Effect of Periodontal Therapy on the Level of MMP-8 in Patients with Chronic Periodontitis

Abstract

Objective The complete removal of bacterial plaque and their endotoxins in deeper areas of periodontal pockets is often difficult to achieve with conventional methods such as periodontal pocket curettage. An alternative to these methods that recently gained popularity in periodontology is the diode laser, with its antibacterial effect, angiogenesis promotion as advantages. Materials and Methods This study included 100 patients diagnosed with chronic periodontitis, with periodontal pockets up to 6 mm, and who were divided into two groups: patients treated with basic therapy and diode laser application, and patients treated with basic therapy and with flap surgery. The clinical periodontal evaluation was done before the treatment and 6 months after the treatment. Evaluation of matrix metalloproteinase (MMP)-8 as an inflammatory indicator in gingival exudate was done with dipstick immunoassay test before the treatment and 6 months later. Results This study showed a more pronounced improvement of periodontal clinical parameters, as well as a decrease in MMP-8 values in gingival exudate in the laser-treated group compared with the surgically treated group. Conclusion The results of this study are encouraging for the use of the diode laser as a noninvasive method in the treatment of periodontal pathologies.

To Explore and Analyze the Safety and Clinical Efficacy of Periocline-Assisted Periodontal Basic Therapy on Chronic Periodontitis

“…At the same time, after the disease has progressed, parthenogenic anaerobes are also involved, mainly Streptococcus pyogenes , Staphylococcus aureus , and Staphylococcus epidermidis . These microorganisms could produce and release proteolytic enzymes and toxic metabolites that cause damage to periodontal tissues, and factors related to inflammation could also be produced through their stimulation of host cells [ 10 , 11 ]. Therefore, in recent years, with the development of preventive dentistry, oral bacteria, soft tartar, and tartar have become the main target of prevention and treatment, but only with periodontal mechanical and surgical treatment can not completely control the inflammation around them.…”

Effect of Low-Level Laser Therapy on Early Wound Healing and Levels of Inflammatory Mediators in Gingival Crevicular Fluid Following Open Flap Debridement

“…But as compared to traditional methods of assessment, these biomarkers demonstrate optimum prediction of site-specific prognosis and outcome of therapy. Although precise cutoff values for these biomarkers cannot be determined, the increase and decrease of these biomarkers serve as an important tool for assessing biological events occurring at the molecular level in the pocket lining [4,[14][15][16][17][18].…”

“…MMP-8 is described as a surrogate indicator of neutrophil density as it is stored in secretory granules and released during inflammation. MMP-8 and MMP-9 are the main collagenases for the degradation of type I and type III collagen [18]. Increased levels of host and microbial-derived proteinases (MMPs) are responsible for extracellular matrix degradation in periodontal disease.…”

The Severity of Periodontitis in Elderly Patients with Type 2 Diabetes Mellitus: A Community-Based Study

“…Probing depth and CAL measurements were performed on all teeth (full mouth) using a standardized periodontal probe (WHO's periodontal probe) on six surfaces of the examined dentition: mesio-vestibular, vestibular, disto-vestibular, mesio-oral, oral, and disto-oral. 10 PD is the distance from the gingival margin to the bottom of the gingival sulcus or periodontal pocket, while CAL is the distance from the cementoenamel junction (CEJ) to the bottom of the periodontal sulcus or pocket.…”