The effect of periodontal treatment on C-reactive protein: A clinical study

Abstract

Background:Chronic periodontitis in amultifactorial inflammatory disease which is caused by various microorganisms. Many studies have found close association between chronic periodontitis and C-reactive protein (CRP). CRPis an inflammatory marker which increases in all inflammatory condition.Aims and Objective:The present clinical study was designed to show the effect of periodontal treatment on the CRP levels of gingival crevicular fluid and to determine the effect of nonsurgical therapy in minimizing the CRP levels in chronic generalized periodontitis.Material and Method:Gingival crevicular fluid was collected using a micro capillary pipette that was hand calibrated at every 1 mm till 10 mm, from selected sites in the subjects on the 1st, 14th and 45th days.Results and Conclusion:Decreased CRP levels of gingival crevicular fluid were observed at the end of the study. There was a 37% reduction in probing pocket depth and 45% gain in clinical attachment level and a reduction of about 57% after 14 days and 90% reduction of CRP levels in gingival crevicular fluid after 45 days. Thus, the results show that the presence of CRP level is more significant in gingival crevicular fluid and confirms the underlying inflammatory component of the disease activity in chronic periodontitis.

C-Reactive Protein (CRP) and its Association with Periodontal Disease: A Brief Review

“…However, according to Kumar et al, CRP level is more significant in GCF and confirms the underlying inflammatory component of the disease activity in chronic periodontitis. Nonsurgical periodontal treatment was effective in reducing the levels of CRP in GCF, and the levels of GCF biomarkers specific for three aspects of periodontitis -degree of inflammation, collagen degradation and bone turnover -correlated with the clinical features of periodontal disease [35].…”

Effects of smoking severity and moderate and severe periodontitis on serum C-reactive protein levels: an age- and gender-matched retrospective cohort study

“…In the presence of calcium, CRP binds specifically to polysaccharides of the bacterial membranes, which activates the complement pathway and phagocytosis (Bansal et al, 2014;Gani et al, 2009). CRP induces monocytes/macrophages to stimulate the coagulation pathway and increase blood coagulability by releasing tissue factors (Kumar et al, 2013). Therefore, it is considered a serological marker of systemic inflammation and is linked to risk for various systemic conditions, including cardiovascular diseases (Ridker et al, 1997;Ridker, 2003).…”

“…Periodontitis (chronic or aggressive) might cause or accompany the release of acute-phase mediators such as CRP, interleukin-6 and tumor necrosis factor-a, caused by the local bacterial infection or the systemic spread of bacteria or their toxins and products (Bansal et al, 2014;Beck et al, 1996;Black et al, 2004;D'Aiuto et al, 2004b;Joshipura et al, 2004;Kumar et al, 2013;Pitiphat et al, 2006;Pitiphat et al, 2008;Slade et al, 2000). Low-grade systemic infections might have acute phase responses, enhancing the formation of atheromatous plaques (D'Aiuto et al, 2004a;Danesh et al, 2000).…”

“…Hence, it seems that CRP might act as a potential mediator of the association between periodontitis and such systemic diseases (Pitiphat et al, 2008). Numerous researchers have confirmed a positive link between high-serum CRP levels and the presence of chronic or severe periodontitis (Bansal et al, 2014;D'Aiuto et al, 2004a;Dye et al, 2005;Ebersole et al, 1997;Fredriksson et al, 1999;Gomes-Filho et al, 2011;Iwamoto et al, 2003;Kumar et al, 2013;Loos et al, 2000;Noack et al, 2001;Persson et al, 2005;Pitiphat et al, 2008;Saito et al, 2003;Salzberg et al, 2006;Slade et al, 2000) as a dose-dependent correlation (D'Aiuto et al, 2004a). However, the association between periodontal status and CRP levels is not determined (Pitiphat et al, 2008), as not all the studies have verified the association between CRP and periodontal disease, probably due to different methodological variations such as different periodontal diseases studied as well as the confounding effects of other factors (Bansal et al, 2014;Bretz et al, 2005;Craig et al, 2003;D'Aiuto et al, 2004a;Tuter et al, 2010).…”

Gingivitis and lifestyle influences on high‐sensitivity C‐reactive protein and interleukin 6 in adolescents

“…) and decrease when periodontal treatment is administered (Kumar et al. , Jayaprakash et al. , Mohan et al.…”