The Effect of Perioperative Topical Ketorolac 0.5% on Macular Thickness after Uneventful Phacoemulsification

Abstract

Background To evaluate the effects of topical 0.5% ketorolac treatment combined with topical steroids on macular thickness in cases who had uneventful phacoemulsification surgery. Methods 58 eyes of 58 consecutive cases were included. The mean foveal thickness (MFT), parafoveal thickness (ParaFT), and perifoveal thickness (PeriFT) measurements were performed with optical coherence tomography (RTVue-100, Optovue, Fremont, CA, USA) preoperatively and at postoperative 1 week, 1 month, and 2 months. All cases received topical 0.1% dexamethasone postoperatively. Randomly selected cases additionally received topical 0.5% ketorolac, which started 2 days prior to surgery. Cases who received both topical steroids and ketorolac formed group 1 and subjects who received only topical steroids formed group 2. Results The increase in mean MFT at the 1st week, 1st month, and 2nd months after surgery in group 1 was significantly lower than group 2 (P = 0.008, P ≤ 0.001, and P ≤ 0.001, resp.). In group 1, the increase in mean ParaFT and PeriFT was significantly lower than group 2 at the 1st and 2nd months of the surgery (P < 0.05 for all variables). Conclusions Topical ketorolac combined with steroids is highly efficacious in order to prevent increment in thickness on each part of the macula even after an uneventful phacoemulsification surgery comparing to steroid monotheraphy.

Intracameral tenecteplase during phacoemulsification in rabbits: clinical assessment of the anterior segment and biochemical analysis of the aqueous humor

“…The peak of hypertension observed 24 hours after surgery was described as a common postoperative effect in rabbits. Such an occurrence was associated with BAB disruption, excessive motion of fluids during irrigation, manipulation of intraocular structures and even permanence of viscoelastic agents in the AC (7,8,20,21) . The IOP reductions observed at TP 15 compared with TP 0 in both groups were likely a reflection of postoperative uveitis.…”

The management of Irvine-Gass Syndrome in a patient using Inhaler Steroid

“…So, we started topical NSAID treatment at postoperative month 1, in addition to topical steroid which was given for post-cataract treatment. Even still, there are no evidence-based guidelines for the treatment of Irvine-Gass syndrome, several studies have reported signi icant reductions in the macular edema with the topical therapy, after cataract surgery [11][12][13][14]. Combination therapy with topical NSAID and corticosteroidis signi icantly more effective than only corticosteroid in treatment of Irvine-Gass syndrome [15].…”

Management of inflammation after the cataract surgery

“…Dal et al evaluated the effects of topical 0.5% ketorolac treatment, which started 2 days prior to the surgery combined with topical steroids on macular thickness in cases who had no risk factors and uneventful phacoemulsification. Control group was patients who received only steroids and results showed that the increase in mean foveal thickness at the first week, first and second months after surgery was significantly lower in NSAIDs group but again, authors excluded all PCME cases from the statistical analysis [82].…”