The Effect of Pesticides on the Microbiome of Animals

Syromyatnikov, Mikhail; Isuwa, Mariya M.; Savinkova, O. V.; Derevshchikova, M. I.; Popov, Vasily N.

doi:10.3390/agriculture10030079

Cited by 56 publications

(33 citation statements)

References 116 publications

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“…The mechanisms of interaction between pesticides and GM have been hypothesized in other studies [ 28 , 29 ] and will therefore be described shortly in this manuscript. Regarding how pesticides can interact with GM, the main types of interactions are illustrated in Figure 1 .…”

Section: Introductionmentioning

confidence: 98%

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Giambò

Teodoro

Costa

et al. 2021

IJERPH

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In recent years, new targets have been included between the health outcomes induced by pesticide exposure. The gastrointestinal tract is a key physical and biological barrier and it represents a primary site of exposure to toxic agents. Recently, the intestinal microbiota has emerged as a notable factor regulating pesticides’ toxicity. However, the specific mechanisms related to this interaction are not well known. In this review, we discuss the influence of pesticide exposure on the gut microbiota, discussing the factors influencing gut microbial diversity, and we summarize the updated literature. In conclusion, more studies are needed to clarify the host–microbial relationship concerning pesticide exposure and to define new prevention interventions, such as the identification of biomarkers of mucosal barrier function.

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Section: Introductionmentioning

confidence: 98%

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Giambò

Teodoro

Costa

et al. 2021

IJERPH

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“…In the case of their penetration into the human or animal body, they can lead to microbiological flora disorders. A reduction in the number and diversity of bacterial intestinal flora in rats was demonstrated after administration of the triazole fungicide penconazole, which may subsequently translate into the increased ability of a portion of the fungal pathogen cell population to colonize various niches within the mammalian host [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

Synthetic Pesticides Used in Agricultural Production Promote Genetic Instability and Metabolic Variability in Candida spp.

Potocki

Baran

Oklejewicz

et al. 2020

Genes

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The effects of triazole fungicide Tango® (epoxiconazole) and two neonicotinoid insecticide formulations Mospilan® (acetamiprid) and Calypso® (thiacloprid) were investigated in Candida albicans and three non-albicans species Candida pulcherrima, Candida glabrata and Candida tropicalis to assess the range of morphological, metabolic and genetic changes after their exposure to pesticides. Moreover, the bioavailability of pesticides, which gives us information about their metabolization was assessed using gas chromatography-mass spectrophotometry (GC-MS). The tested pesticides caused differences between the cells of the same species in the studied populations in response to ROS accumulation, the level of DNA damage, changes in fatty acids (FAs) and phospholipid profiles, change in the percentage of unsaturated to saturated FAs or the ability to biofilm. In addition, for the first time, the effect of tested neonicotinoid insecticides on the change of metabolic profile of colony cells during aging was demonstrated. Our data suggest that widely used pesticides, including insecticides, may increase cellular diversity in the Candida species population-known as clonal heterogeneity-and thus play an important role in acquiring resistance to antifungal agents.

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“…One study found that glyphosate-based herbicides altered gut microbiomes and reproductive hormone levels in Japanese quails ( Coturnix japonica ) in a long-term study, but did not directly affect reproduction in either sex (maturation, testis size or egg production) [ 130 ]. Future studies on the effects of environmental contaminants on reproductive microbiomes should consider that these interactions may be subtle or potentially delayed in order to fully understand the risks related to contaminant exposure [ 131 ].…”

Section: Link Between Microbiomes Reproduction and Environmental Changesmentioning

confidence: 99%

Interactions between reproductive biology and microbiomes in wild animal species

et al. 2021

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Many parts of the animal body harbor microbial communities, known as animal-associated microbiomes, that affect the regulation of physiological functions. Studies in human and animal models have demonstrated that the reproductive biology and such microbiomes also interact. However, this concept is poorly studied in wild animal species and little is known about the implications to fertility, parental/offspring health, and survival in natural habitats. The objective of this review is to (1) specify the interactions between animals’ reproductive biology, including reproductive signaling, pregnancy, and offspring development, and their microbiomes, with an emphasis on wild species and (2) identify important research gaps as well as areas for further studies. While microbiomes present in the reproductive tract play the most direct role, other bodily microbiomes may also contribute to facilitating reproduction. In fish, amphibians, reptiles, birds, and mammals, endogenous processes related to the host physiology and behavior (visual and olfactory reproductive signals, copulation) can both influence and be influenced by the structure and function of microbial communities. In addition, exposures to maternal microbiomes in mammals (through vagina, skin, and milk) shape the offspring microbiomes, which, in turn, affects health later in life. Importantly, for all wild animal species, host-associated microbiomes are also influenced by environmental variations. There is still limited literature on wild animals compared to the large body of research on model species and humans. However, the few studies in wild species clearly highlight the necessity of increased research in rare and endangered animals to optimize conservation efforts in situ and ex situ. Thus, the link between microbiomes and reproduction is an emerging and critical component in wild animal conservation.

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The Effect of Pesticides on the Microbiome of Animals

Cited by 56 publications

References 116 publications

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Synthetic Pesticides Used in Agricultural Production Promote Genetic Instability and Metabolic Variability in Candida spp.

Interactions between reproductive biology and microbiomes in wild animal species

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