The effect of pH and DNA concentration on organic thin-film transistor biosensors

Khan, Hadayat Ullah; Roberts, Mark; Johnson, Olasupo B.; Knoll, Wolfgang; Bao, Zhenan

doi:10.1016/j.orgel.2011.12.013

Cited by 32 publications

(23 citation statements)

References 25 publications

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“…29 Furthermore, small molecular organic semiconductors, such as DDFTTF with hydrophobic long dodecyl alkyl chains attached to the conjugated backbone, have been developed to fabricate water-stable organic electronic devices. [32][33][34]107 This molecular design strategy can provide a waterproof surface on an organic semiconducting layer with dense molecular packing, which is highly effective for the fabrication of water-stable organic chemical sensors and biosensors. In the case of OPTs, rational molecular design in the chemistry aspect is highly desirable for achieving high-performance OPTs.…”

Section: Materials Development For Ofet-based Sensors: Chemistry Aspectmentioning

confidence: 99%

Flexible Field-Effect Transistor-Type Sensors Based on Conjugated Molecules

Lee

Jang

Lee

et al. 2017

Chem

171

125

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With the advent of the Internet of Things (IoT) era, flexible sensors are regarded as one of the most important technologies for the development of humanfriendly wearable devices. Organic field-effect transistors (OFETs) based on conjugated polymers or small molecules are promising sensor platforms because they have various advantages, including high sensitivity, mechanical flexibility, and low-cost fabrication processes. OFET-based sensors enable continuous monitoring of external stimuli or target analytes with superior detection capabilities. This review describes the working principles and sensing mechanisms of various OFET-based sensors, including chemical, biological, photo, pressure, and temperature sensors, and introduces the recent progress in this field. In addition, the technical challenges and future outlook of OFETbased sensors for next-generation flexible electronics are briefly discussed.

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Section: Materials Development For Ofet-based Sensors: Chemistry Aspectmentioning

confidence: 99%

Flexible Field-Effect Transistor-Type Sensors Based on Conjugated Molecules

Lee

Jang

Lee

et al. 2017

Chem

171

125

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“…Fluorine–thiophene oligomers have emerged as highly stable semiconducting materials with good mobility—greater than 0.1 cm 2 V −1 s −1 —and a relatively high on–off ratio. Among the various fluorine–thiophene oligomeric semiconductors, 5,5′‐bis‐(7‐dodecyl‐9 H ‐fluoren‐2‐yl)‐2,2′‐bithiophene (DDFTTF) has been widely used to fabricate water‐stable organic electronics, including chemical sensors and biosensors, because of its long dodecyl‐substituted and hydrophobic alkyl side chains, which can effectively shield the main backbone where the actual charge transport occurs by closely packing to reduce degradation …”

Section: Approaches To Overcome the Instability Caused By Degradationmentioning

confidence: 99%

Toward Environmentally Robust Organic Electronics: Approaches and Applications

et al. 2017

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Recent interest in flexible electronics has led to a paradigm shift in consumer electronics, and the emergent development of stretchable and wearable electronics is opening a new spectrum of ubiquitous applications for electronics. Organic electronic materials, such as π-conjugated small molecules and polymers, are highly suitable for use in low-cost wearable electronic devices, and their charge-carrier mobilities have now exceeded that of amorphous silicon. However, their commercialization is minimal, mainly because of weaknesses in terms of operational stability, long-term stability under ambient conditions, and chemical stability related to fabrication processes. Recently, however, many attempts have been made to overcome such instabilities of organic electronic materials. Here, an overview is provided of the strategies developed for environmentally robust organic electronics to overcome the detrimental effects of various critical factors such as oxygen, water, chemicals, heat, and light. Additionally, molecular design approaches to π-conjugated small molecules and polymers that are highly stable under ambient and harsh conditions are explored; such materials will circumvent the need for encapsulation and provide a greater degree of freedom using simple solution-based device-fabrication techniques. Applications that are made possible through these strategies are highlighted.

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“…17 In all these reports and others in the literature, the researchers used exclusively P-type semiconductors, such as pentacene, in a variety of OTFT DNA sensor device architectures. 18,[21][22][23][24] An aspect of sensor design for most OTFT-based DNA sensors that has been overlooked is the required elevated temperature for DNA binding. To ensure specic binding of DNA, either at the point of detection or before, the strands must be in solution at a specic setpoint below the melting temperature (T M ) of the particular DNA sequences being investigated.…”

Section: Introductionmentioning

confidence: 99%